| Full name: REC8 meiotic recombination protein | Alias Symbol: Rec8p|kleisin-alpha | ||
| Type: protein-coding gene | Cytoband: 14q12 | ||
| Entrez ID: 9985 | HGNC ID: HGNC:16879 | Ensembl Gene: ENSG00000100918 | OMIM ID: 608193 |
| Drug and gene relationship at DGIdb | |||
REC8 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04114 | Oocyte meiosis |
Expression of REC8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | REC8 | 9985 | 218599_at | 0.6050 | 0.4237 | |
| GSE20347 | REC8 | 9985 | 218599_at | 0.2094 | 0.0936 | |
| GSE23400 | REC8 | 9985 | 218599_at | 0.2962 | 0.0000 | |
| GSE26886 | REC8 | 9985 | 218599_at | 0.2757 | 0.0838 | |
| GSE29001 | REC8 | 9985 | 218599_at | 0.2271 | 0.3485 | |
| GSE38129 | REC8 | 9985 | 218599_at | 0.0029 | 0.9859 | |
| GSE45670 | REC8 | 9985 | 218599_at | 0.7006 | 0.0001 | |
| GSE53622 | REC8 | 9985 | 989 | -0.1228 | 0.5550 | |
| GSE53624 | REC8 | 9985 | 989 | 0.3265 | 0.0078 | |
| GSE63941 | REC8 | 9985 | 218599_at | 0.1778 | 0.3762 | |
| GSE77861 | REC8 | 9985 | 218599_at | 0.1518 | 0.1695 | |
| GSE97050 | REC8 | 9985 | A_33_P3278941 | 0.1917 | 0.4516 | |
| SRP064894 | REC8 | 9985 | RNAseq | 1.5261 | 0.0000 | |
| SRP133303 | REC8 | 9985 | RNAseq | 0.4478 | 0.0659 | |
| SRP193095 | REC8 | 9985 | RNAseq | 0.4966 | 0.0605 | |
| SRP219564 | REC8 | 9985 | RNAseq | 0.6586 | 0.0899 | |
| TCGA | REC8 | 9985 | RNAseq | -0.6965 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by REC8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of REC8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | REC8 | 9985 | 8 | 3 | 19 | |
| GSE20123 | REC8 | 9985 | 8 | 3 | 19 | |
| GSE43470 | REC8 | 9985 | 8 | 2 | 33 | |
| GSE46452 | REC8 | 9985 | 16 | 2 | 41 | |
| GSE47630 | REC8 | 9985 | 11 | 10 | 19 | |
| GSE54993 | REC8 | 9985 | 3 | 11 | 56 | |
| GSE54994 | REC8 | 9985 | 18 | 5 | 30 | |
| GSE60625 | REC8 | 9985 | 0 | 2 | 9 | |
| GSE74703 | REC8 | 9985 | 7 | 2 | 27 | |
| GSE74704 | REC8 | 9985 | 3 | 2 | 15 | |
| TCGA | REC8 | 9985 | 27 | 13 | 56 |
Total number of gains: 109; Total number of losses: 55; Total Number of normals: 324.
Somatic mutations of REC8:
Generating mutation plots.
Highly correlated genes for REC8:
Showing top 20/846 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| REC8 | R3HDM2 | 0.819304 | 3 | 0 | 3 |
| REC8 | CYHR1 | 0.774491 | 3 | 0 | 3 |
| REC8 | BCL9L | 0.772537 | 3 | 0 | 3 |
| REC8 | C9orf64 | 0.762075 | 3 | 0 | 3 |
| REC8 | CHD3 | 0.745829 | 4 | 0 | 4 |
| REC8 | KCTD15 | 0.744353 | 3 | 0 | 3 |
| REC8 | ARF1 | 0.742131 | 4 | 0 | 4 |
| REC8 | ZBED1 | 0.740915 | 3 | 0 | 3 |
| REC8 | LYAR | 0.737067 | 4 | 0 | 4 |
| REC8 | EGR2 | 0.732346 | 3 | 0 | 3 |
| REC8 | CEP250 | 0.720608 | 4 | 0 | 4 |
| REC8 | MED12 | 0.717641 | 3 | 0 | 3 |
| REC8 | TOP1MT | 0.715522 | 4 | 0 | 4 |
| REC8 | TANC2 | 0.715503 | 3 | 0 | 3 |
| REC8 | PDE7A | 0.713505 | 4 | 0 | 3 |
| REC8 | LRRC56 | 0.711596 | 3 | 0 | 3 |
| REC8 | CAMTA2 | 0.711466 | 3 | 0 | 3 |
| REC8 | VEGFB | 0.711147 | 3 | 0 | 3 |
| REC8 | RHBDD2 | 0.710934 | 3 | 0 | 3 |
| REC8 | SUGP2 | 0.710824 | 3 | 0 | 3 |
For details and further investigation, click here
