| Full name: protein tyrosine phosphatase non-receptor type 23 | Alias Symbol: DKFZP564F0923|KIAA1471|HD-PTP | ||
| Type: protein-coding gene | Cytoband: 3p21.31 | ||
| Entrez ID: 25930 | HGNC ID: HGNC:14406 | Ensembl Gene: ENSG00000076201 | OMIM ID: 606584 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of PTPN23:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PTPN23 | 25930 | 223150_s_at | 0.2868 | 0.5525 | |
| GSE26886 | PTPN23 | 25930 | 223150_s_at | 0.2501 | 0.1093 | |
| GSE45670 | PTPN23 | 25930 | 223150_s_at | -0.0402 | 0.5705 | |
| GSE53622 | PTPN23 | 25930 | 104546 | -0.2711 | 0.0000 | |
| GSE53624 | PTPN23 | 25930 | 14154 | -0.1110 | 0.0876 | |
| GSE63941 | PTPN23 | 25930 | 223150_s_at | -0.4034 | 0.0818 | |
| GSE77861 | PTPN23 | 25930 | 223150_s_at | -0.0814 | 0.7569 | |
| GSE97050 | PTPN23 | 25930 | A_23_P212329 | 0.2213 | 0.4164 | |
| SRP007169 | PTPN23 | 25930 | RNAseq | 0.6917 | 0.1862 | |
| SRP008496 | PTPN23 | 25930 | RNAseq | 0.4147 | 0.2846 | |
| SRP064894 | PTPN23 | 25930 | RNAseq | -0.0543 | 0.7449 | |
| SRP133303 | PTPN23 | 25930 | RNAseq | -0.4316 | 0.0003 | |
| SRP159526 | PTPN23 | 25930 | RNAseq | -0.3732 | 0.0505 | |
| SRP193095 | PTPN23 | 25930 | RNAseq | -0.1432 | 0.3443 | |
| SRP219564 | PTPN23 | 25930 | RNAseq | -0.0507 | 0.8897 | |
| TCGA | PTPN23 | 25930 | RNAseq | -0.0369 | 0.3888 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PTPN23 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PTPN23:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PTPN23 | 25930 | 0 | 18 | 12 | |
| GSE20123 | PTPN23 | 25930 | 0 | 19 | 11 | |
| GSE43470 | PTPN23 | 25930 | 0 | 19 | 24 | |
| GSE46452 | PTPN23 | 25930 | 2 | 17 | 40 | |
| GSE47630 | PTPN23 | 25930 | 2 | 23 | 15 | |
| GSE54993 | PTPN23 | 25930 | 7 | 2 | 61 | |
| GSE54994 | PTPN23 | 25930 | 0 | 36 | 17 | |
| GSE60625 | PTPN23 | 25930 | 5 | 0 | 6 | |
| GSE74703 | PTPN23 | 25930 | 0 | 15 | 21 | |
| GSE74704 | PTPN23 | 25930 | 0 | 12 | 8 | |
| TCGA | PTPN23 | 25930 | 1 | 75 | 20 |
Total number of gains: 17; Total number of losses: 236; Total Number of normals: 235.
Somatic mutations of PTPN23:
Generating mutation plots.
Highly correlated genes for PTPN23:
Showing top 20/344 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PTPN23 | MIER2 | 0.815577 | 3 | 0 | 3 |
| PTPN23 | ADCK1 | 0.806094 | 3 | 0 | 3 |
| PTPN23 | RHOG | 0.793889 | 3 | 0 | 3 |
| PTPN23 | SUGP1 | 0.79234 | 3 | 0 | 3 |
| PTPN23 | PLXNA2 | 0.791849 | 3 | 0 | 3 |
| PTPN23 | TNPO3 | 0.787042 | 3 | 0 | 3 |
| PTPN23 | PROSER1 | 0.78152 | 3 | 0 | 3 |
| PTPN23 | ZC3H3 | 0.78117 | 3 | 0 | 3 |
| PTPN23 | TRAPPC10 | 0.772772 | 3 | 0 | 3 |
| PTPN23 | CCAR1 | 0.772764 | 3 | 0 | 3 |
| PTPN23 | SLC25A38 | 0.768536 | 3 | 0 | 3 |
| PTPN23 | NUFIP1 | 0.76141 | 3 | 0 | 3 |
| PTPN23 | ZNF502 | 0.750923 | 3 | 0 | 3 |
| PTPN23 | CDC73 | 0.746141 | 3 | 0 | 3 |
| PTPN23 | CHD3 | 0.742349 | 3 | 0 | 3 |
| PTPN23 | MRFAP1 | 0.741454 | 3 | 0 | 3 |
| PTPN23 | RAB7A | 0.736815 | 3 | 0 | 3 |
| PTPN23 | CLCN7 | 0.732149 | 3 | 0 | 3 |
| PTPN23 | DALRD3 | 0.729787 | 3 | 0 | 3 |
| PTPN23 | FAM193B | 0.725089 | 3 | 0 | 3 |
For details and further investigation, click here
