| Full name: cholinergic receptor muscarinic 3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1q43 | ||
| Entrez ID: 1131 | HGNC ID: HGNC:1952 | Ensembl Gene: ENSG00000133019 | OMIM ID: 118494 |
| Drug and gene relationship at DGIdb | |||
CHRM3 involved pathways:
Expression of CHRM3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CHRM3 | 1131 | 242488_at | -1.9160 | 0.1138 | |
| GSE20347 | CHRM3 | 1131 | 214596_at | 1.3755 | 0.0000 | |
| GSE23400 | CHRM3 | 1131 | 214596_at | -0.0728 | 0.4410 | |
| GSE26886 | CHRM3 | 1131 | 242488_at | 3.6500 | 0.0000 | |
| GSE29001 | CHRM3 | 1131 | 214596_at | 0.9673 | 0.0436 | |
| GSE38129 | CHRM3 | 1131 | 214596_at | 0.5514 | 0.1005 | |
| GSE45670 | CHRM3 | 1131 | 242488_at | -2.2592 | 0.0003 | |
| GSE53622 | CHRM3 | 1131 | 74815 | -0.1473 | 0.3062 | |
| GSE53624 | CHRM3 | 1131 | 74815 | 0.0286 | 0.7627 | |
| GSE63941 | CHRM3 | 1131 | 242488_at | 0.2289 | 0.8530 | |
| GSE77861 | CHRM3 | 1131 | 1553705_a_at | 0.6646 | 0.0155 | |
| GSE97050 | CHRM3 | 1131 | A_23_P401472 | -0.7212 | 0.3723 | |
| SRP007169 | CHRM3 | 1131 | RNAseq | 3.3662 | 0.0003 | |
| SRP008496 | CHRM3 | 1131 | RNAseq | 3.3710 | 0.0000 | |
| SRP064894 | CHRM3 | 1131 | RNAseq | -0.6664 | 0.0411 | |
| SRP133303 | CHRM3 | 1131 | RNAseq | 0.3472 | 0.4566 | |
| SRP159526 | CHRM3 | 1131 | RNAseq | 0.5894 | 0.0564 | |
| SRP193095 | CHRM3 | 1131 | RNAseq | 1.4739 | 0.0000 | |
| SRP219564 | CHRM3 | 1131 | RNAseq | -0.1616 | 0.8313 | |
| TCGA | CHRM3 | 1131 | RNAseq | -0.5418 | 0.0129 |
Upregulated datasets: 5; Downregulated datasets: 1.
Survival by CHRM3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CHRM3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CHRM3 | 1131 | 8 | 2 | 20 | |
| GSE20123 | CHRM3 | 1131 | 8 | 2 | 20 | |
| GSE43470 | CHRM3 | 1131 | 7 | 1 | 35 | |
| GSE46452 | CHRM3 | 1131 | 4 | 2 | 53 | |
| GSE47630 | CHRM3 | 1131 | 15 | 0 | 25 | |
| GSE54993 | CHRM3 | 1131 | 0 | 6 | 64 | |
| GSE54994 | CHRM3 | 1131 | 16 | 0 | 37 | |
| GSE60625 | CHRM3 | 1131 | 0 | 0 | 11 | |
| GSE74703 | CHRM3 | 1131 | 7 | 1 | 28 | |
| GSE74704 | CHRM3 | 1131 | 2 | 1 | 17 | |
| TCGA | CHRM3 | 1131 | 44 | 5 | 47 |
Total number of gains: 111; Total number of losses: 20; Total Number of normals: 357.
Somatic mutations of CHRM3:
Generating mutation plots.
Highly correlated genes for CHRM3:
Showing top 20/452 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CHRM3 | DACT3 | 0.760337 | 4 | 0 | 4 |
| CHRM3 | MICU3 | 0.719752 | 4 | 0 | 4 |
| CHRM3 | TCEAL3 | 0.715813 | 3 | 0 | 3 |
| CHRM3 | SMAD9 | 0.70988 | 5 | 0 | 5 |
| CHRM3 | MTURN | 0.706796 | 3 | 0 | 3 |
| CHRM3 | GKAP1 | 0.703497 | 3 | 0 | 3 |
| CHRM3 | STON1 | 0.698253 | 7 | 0 | 7 |
| CHRM3 | REPS2 | 0.687942 | 3 | 0 | 3 |
| CHRM3 | SUPT6H | 0.683535 | 3 | 0 | 3 |
| CHRM3 | IGSF10 | 0.674544 | 3 | 0 | 3 |
| CHRM3 | FGF14-AS2 | 0.671906 | 4 | 0 | 4 |
| CHRM3 | ANTXR2 | 0.669169 | 5 | 0 | 3 |
| CHRM3 | LINC00674 | 0.667925 | 3 | 0 | 3 |
| CHRM3 | FARP1 | 0.66588 | 6 | 0 | 4 |
| CHRM3 | TJAP1 | 0.66511 | 4 | 0 | 4 |
| CHRM3 | NRK | 0.662717 | 4 | 0 | 3 |
| CHRM3 | MPDZ | 0.661867 | 10 | 0 | 10 |
| CHRM3 | NR2F1-AS1 | 0.660412 | 4 | 0 | 4 |
| CHRM3 | WIF1 | 0.658848 | 5 | 0 | 5 |
| CHRM3 | A2M-AS1 | 0.657749 | 4 | 0 | 4 |
For details and further investigation, click here
