| Full name: WNT inhibitory factor 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 12q14.3 | ||
| Entrez ID: 11197 | HGNC ID: HGNC:18081 | Ensembl Gene: ENSG00000156076 | OMIM ID: 605186 |
| Drug and gene relationship at DGIdb | |||
WIF1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04310 | Wnt signaling pathway |
Expression of WIF1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | WIF1 | 11197 | 204712_at | -2.9509 | 0.0493 | |
| GSE20347 | WIF1 | 11197 | 204712_at | 0.0546 | 0.9389 | |
| GSE23400 | WIF1 | 11197 | 204712_at | -0.2312 | 0.1271 | |
| GSE26886 | WIF1 | 11197 | 204712_at | 1.1613 | 0.1969 | |
| GSE29001 | WIF1 | 11197 | 204712_at | -0.1905 | 0.9000 | |
| GSE38129 | WIF1 | 11197 | 204712_at | -0.6335 | 0.1718 | |
| GSE45670 | WIF1 | 11197 | 204712_at | -3.4186 | 0.0003 | |
| GSE53622 | WIF1 | 11197 | 37440 | -1.3491 | 0.0001 | |
| GSE53624 | WIF1 | 11197 | 37440 | -1.5892 | 0.0000 | |
| GSE63941 | WIF1 | 11197 | 204712_at | 0.0658 | 0.8001 | |
| GSE77861 | WIF1 | 11197 | 204712_at | 1.3104 | 0.3779 | |
| GSE97050 | WIF1 | 11197 | A_32_P216520 | -0.8931 | 0.2834 | |
| SRP064894 | WIF1 | 11197 | RNAseq | -3.4432 | 0.0001 | |
| SRP133303 | WIF1 | 11197 | RNAseq | 0.5649 | 0.6791 | |
| SRP159526 | WIF1 | 11197 | RNAseq | 3.5755 | 0.0018 | |
| TCGA | WIF1 | 11197 | RNAseq | -1.3183 | 0.1298 |
Upregulated datasets: 1; Downregulated datasets: 5.
Survival by WIF1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of WIF1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | WIF1 | 11197 | 5 | 1 | 24 | |
| GSE20123 | WIF1 | 11197 | 5 | 1 | 24 | |
| GSE43470 | WIF1 | 11197 | 5 | 0 | 38 | |
| GSE46452 | WIF1 | 11197 | 11 | 0 | 48 | |
| GSE47630 | WIF1 | 11197 | 10 | 2 | 28 | |
| GSE54993 | WIF1 | 11197 | 0 | 7 | 63 | |
| GSE54994 | WIF1 | 11197 | 6 | 1 | 46 | |
| GSE60625 | WIF1 | 11197 | 0 | 0 | 11 | |
| GSE74703 | WIF1 | 11197 | 5 | 0 | 31 | |
| GSE74704 | WIF1 | 11197 | 4 | 1 | 15 | |
| TCGA | WIF1 | 11197 | 21 | 9 | 66 |
Total number of gains: 72; Total number of losses: 22; Total Number of normals: 394.
Somatic mutations of WIF1:
Generating mutation plots.
Highly correlated genes for WIF1:
Showing top 20/113 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| WIF1 | SCARA5 | 0.695758 | 3 | 0 | 3 |
| WIF1 | MICU3 | 0.692733 | 4 | 0 | 3 |
| WIF1 | KCNE3 | 0.67587 | 3 | 0 | 3 |
| WIF1 | NRXN3 | 0.672333 | 4 | 0 | 4 |
| WIF1 | RPL31 | 0.662622 | 4 | 0 | 3 |
| WIF1 | COX20 | 0.660919 | 3 | 0 | 3 |
| WIF1 | CHRM3 | 0.658848 | 5 | 0 | 5 |
| WIF1 | LINC00667 | 0.654851 | 3 | 0 | 3 |
| WIF1 | PLCB4 | 0.654692 | 8 | 0 | 6 |
| WIF1 | LY6H | 0.643754 | 3 | 0 | 3 |
| WIF1 | ENPP1 | 0.640213 | 3 | 0 | 3 |
| WIF1 | PTPRN2 | 0.63061 | 4 | 0 | 3 |
| WIF1 | RAB9B | 0.624671 | 4 | 0 | 3 |
| WIF1 | FGF13 | 0.624435 | 5 | 0 | 4 |
| WIF1 | CA4 | 0.623796 | 3 | 0 | 3 |
| WIF1 | TMEM255A | 0.623445 | 5 | 0 | 3 |
| WIF1 | ERCC6L2 | 0.621192 | 4 | 0 | 3 |
| WIF1 | EDN3 | 0.619388 | 6 | 0 | 3 |
| WIF1 | FZD7 | 0.618645 | 4 | 0 | 3 |
| WIF1 | SDC2 | 0.616041 | 3 | 0 | 3 |
For details and further investigation, click here
