| Full name: SMAD family member 9 | Alias Symbol: SMAD8|SMAD8/9 | ||
| Type: protein-coding gene | Cytoband: 13q13.3 | ||
| Entrez ID: 4093 | HGNC ID: HGNC:6774 | Ensembl Gene: ENSG00000120693 | OMIM ID: 603295 |
| Drug and gene relationship at DGIdb | |||
SMAD9 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04350 | TGF-beta signaling pathway | |
| hsa04550 | Signaling pathways regulating pluripotency of stem cells |
Expression of SMAD9:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SMAD9 | 4093 | 227719_at | -1.2304 | 0.3685 | |
| GSE20347 | SMAD9 | 4093 | 206320_s_at | -0.0125 | 0.8771 | |
| GSE23400 | SMAD9 | 4093 | 206320_s_at | -0.0973 | 0.0018 | |
| GSE26886 | SMAD9 | 4093 | 227719_at | 1.5029 | 0.0114 | |
| GSE29001 | SMAD9 | 4093 | 206320_s_at | -0.1561 | 0.2463 | |
| GSE38129 | SMAD9 | 4093 | 206320_s_at | -0.2653 | 0.0162 | |
| GSE45670 | SMAD9 | 4093 | 227719_at | -2.5690 | 0.0000 | |
| GSE53622 | SMAD9 | 4093 | 51591 | -0.8791 | 0.0000 | |
| GSE53624 | SMAD9 | 4093 | 96532 | -0.6460 | 0.0000 | |
| GSE63941 | SMAD9 | 4093 | 227719_at | -3.7377 | 0.0019 | |
| GSE77861 | SMAD9 | 4093 | 206320_s_at | 0.0153 | 0.8986 | |
| GSE97050 | SMAD9 | 4093 | A_23_P2814 | -0.7592 | 0.2580 | |
| SRP007169 | SMAD9 | 4093 | RNAseq | 1.1190 | 0.1079 | |
| SRP008496 | SMAD9 | 4093 | RNAseq | 2.4713 | 0.0000 | |
| SRP064894 | SMAD9 | 4093 | RNAseq | 0.2471 | 0.4669 | |
| SRP133303 | SMAD9 | 4093 | RNAseq | -1.1517 | 0.0000 | |
| SRP159526 | SMAD9 | 4093 | RNAseq | -0.5977 | 0.1177 | |
| SRP193095 | SMAD9 | 4093 | RNAseq | -0.2026 | 0.3695 | |
| SRP219564 | SMAD9 | 4093 | RNAseq | -0.2070 | 0.8200 | |
| TCGA | SMAD9 | 4093 | RNAseq | -0.9214 | 0.0004 |
Upregulated datasets: 2; Downregulated datasets: 3.
Survival by SMAD9 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SMAD9:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SMAD9 | 4093 | 0 | 16 | 14 | |
| GSE20123 | SMAD9 | 4093 | 0 | 15 | 15 | |
| GSE43470 | SMAD9 | 4093 | 2 | 14 | 27 | |
| GSE46452 | SMAD9 | 4093 | 0 | 33 | 26 | |
| GSE47630 | SMAD9 | 4093 | 2 | 27 | 11 | |
| GSE54993 | SMAD9 | 4093 | 12 | 2 | 56 | |
| GSE54994 | SMAD9 | 4093 | 1 | 17 | 35 | |
| GSE60625 | SMAD9 | 4093 | 0 | 3 | 8 | |
| GSE74703 | SMAD9 | 4093 | 2 | 11 | 23 | |
| GSE74704 | SMAD9 | 4093 | 0 | 12 | 8 | |
| TCGA | SMAD9 | 4093 | 7 | 40 | 49 |
Total number of gains: 26; Total number of losses: 190; Total Number of normals: 272.
Somatic mutations of SMAD9:
Generating mutation plots.
Highly correlated genes for SMAD9:
Showing top 20/945 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SMAD9 | BHMT2 | 0.814876 | 6 | 0 | 6 |
| SMAD9 | KCNT2 | 0.78834 | 7 | 0 | 7 |
| SMAD9 | NEGR1 | 0.785323 | 6 | 0 | 6 |
| SMAD9 | C1QTNF7 | 0.783342 | 5 | 0 | 5 |
| SMAD9 | SORCS1 | 0.782854 | 4 | 0 | 4 |
| SMAD9 | RNF150 | 0.782124 | 8 | 0 | 8 |
| SMAD9 | ZFPM2 | 0.78205 | 7 | 0 | 7 |
| SMAD9 | MIR100HG | 0.777417 | 5 | 0 | 5 |
| SMAD9 | NLGN1 | 0.77212 | 7 | 0 | 7 |
| SMAD9 | RBM24 | 0.770063 | 6 | 0 | 6 |
| SMAD9 | LRCH2 | 0.765639 | 7 | 0 | 7 |
| SMAD9 | CYS1 | 0.764838 | 7 | 0 | 7 |
| SMAD9 | MRVI1 | 0.762641 | 6 | 0 | 6 |
| SMAD9 | DIXDC1 | 0.754995 | 7 | 0 | 7 |
| SMAD9 | MAGI2-AS3 | 0.753685 | 6 | 0 | 6 |
| SMAD9 | TMEM47 | 0.752312 | 7 | 0 | 7 |
| SMAD9 | COX7A1 | 0.751947 | 6 | 0 | 6 |
| SMAD9 | CADM2 | 0.751016 | 4 | 0 | 4 |
| SMAD9 | MITF | 0.748439 | 6 | 0 | 5 |
| SMAD9 | SLC35F1 | 0.747711 | 4 | 0 | 4 |
For details and further investigation, click here
