| Full name: class II major histocompatibility complex transactivator | Alias Symbol: C2TA|NLRA | ||
| Type: protein-coding gene | Cytoband: 16p13.13 | ||
| Entrez ID: 4261 | HGNC ID: HGNC:7067 | Ensembl Gene: ENSG00000179583 | OMIM ID: 600005 |
| Drug and gene relationship at DGIdb | |||
CIITA involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04612 | Antigen processing and presentation | |
| hsa05145 | Toxoplasmosis | |
| hsa05152 | Tuberculosis | |
| hsa05164 | Influenza A |
Expression of CIITA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CIITA | 4261 | 210925_at | -0.1528 | 0.3839 | |
| GSE20347 | CIITA | 4261 | 210925_at | -0.0015 | 0.9908 | |
| GSE23400 | CIITA | 4261 | 210925_at | -0.1227 | 0.0022 | |
| GSE26886 | CIITA | 4261 | 211884_s_at | 0.1349 | 0.2705 | |
| GSE29001 | CIITA | 4261 | 210925_at | -0.0926 | 0.7050 | |
| GSE38129 | CIITA | 4261 | 210925_at | -0.1584 | 0.1311 | |
| GSE45670 | CIITA | 4261 | 205101_at | 0.1300 | 0.7616 | |
| GSE53622 | CIITA | 4261 | 88248 | -0.0072 | 0.9472 | |
| GSE53624 | CIITA | 4261 | 88248 | -0.5034 | 0.0000 | |
| GSE63941 | CIITA | 4261 | 210925_at | 0.2102 | 0.1954 | |
| GSE77861 | CIITA | 4261 | 210925_at | -0.0150 | 0.9100 | |
| GSE97050 | CIITA | 4261 | A_33_P3324394 | 0.7180 | 0.2513 | |
| SRP007169 | CIITA | 4261 | RNAseq | -0.1789 | 0.7766 | |
| SRP008496 | CIITA | 4261 | RNAseq | -0.1183 | 0.7984 | |
| SRP064894 | CIITA | 4261 | RNAseq | 0.0815 | 0.7759 | |
| SRP133303 | CIITA | 4261 | RNAseq | -0.5224 | 0.0234 | |
| SRP159526 | CIITA | 4261 | RNAseq | -1.0262 | 0.1055 | |
| SRP193095 | CIITA | 4261 | RNAseq | 0.2463 | 0.3621 | |
| SRP219564 | CIITA | 4261 | RNAseq | 1.3620 | 0.0274 | |
| TCGA | CIITA | 4261 | RNAseq | -0.0382 | 0.8395 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by CIITA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CIITA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CIITA | 4261 | 5 | 4 | 21 | |
| GSE20123 | CIITA | 4261 | 5 | 3 | 22 | |
| GSE43470 | CIITA | 4261 | 3 | 3 | 37 | |
| GSE46452 | CIITA | 4261 | 38 | 1 | 20 | |
| GSE47630 | CIITA | 4261 | 14 | 6 | 20 | |
| GSE54993 | CIITA | 4261 | 3 | 5 | 62 | |
| GSE54994 | CIITA | 4261 | 5 | 9 | 39 | |
| GSE60625 | CIITA | 4261 | 4 | 0 | 7 | |
| GSE74703 | CIITA | 4261 | 3 | 2 | 31 | |
| GSE74704 | CIITA | 4261 | 2 | 1 | 17 | |
| TCGA | CIITA | 4261 | 20 | 12 | 64 |
Total number of gains: 102; Total number of losses: 46; Total Number of normals: 340.
Somatic mutations of CIITA:
Generating mutation plots.
Highly correlated genes for CIITA:
Showing top 20/1083 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CIITA | BCAN | 0.82981 | 5 | 0 | 5 |
| CIITA | CYP2A7 | 0.790377 | 5 | 0 | 5 |
| CIITA | RUNX1T1 | 0.770232 | 3 | 0 | 3 |
| CIITA | GML | 0.759344 | 5 | 0 | 5 |
| CIITA | MSH4 | 0.746948 | 3 | 0 | 3 |
| CIITA | OR10H3 | 0.74581 | 6 | 0 | 6 |
| CIITA | AKAP6 | 0.745654 | 5 | 0 | 5 |
| CIITA | ARMC4 | 0.738943 | 5 | 0 | 5 |
| CIITA | MMP26 | 0.736366 | 5 | 0 | 5 |
| CIITA | TMEM212 | 0.736113 | 3 | 0 | 3 |
| CIITA | SSUH2 | 0.73555 | 5 | 0 | 5 |
| CIITA | IFNA10 | 0.735164 | 5 | 0 | 5 |
| CIITA | FOXN3-AS2 | 0.734662 | 5 | 0 | 4 |
| CIITA | SLC5A4 | 0.731206 | 4 | 0 | 4 |
| CIITA | FRMPD4 | 0.729205 | 5 | 0 | 5 |
| CIITA | TNFSF8 | 0.724765 | 5 | 0 | 4 |
| CIITA | MMP19 | 0.724661 | 4 | 0 | 4 |
| CIITA | CGA | 0.722064 | 5 | 0 | 4 |
| CIITA | IFNA7 | 0.722016 | 4 | 0 | 4 |
| CIITA | INSL5 | 0.721253 | 3 | 0 | 3 |
For details and further investigation, click here
