| Full name: cytochrome P450 family 2 subfamily A member 7 | Alias Symbol: CYP2A | ||
| Type: protein-coding gene | Cytoband: 19q13.2 | ||
| Entrez ID: 1549 | HGNC ID: HGNC:2611 | Ensembl Gene: ENSG00000198077 | OMIM ID: 608054 |
| Drug and gene relationship at DGIdb | |||
Expression of CYP2A7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CYP2A7 | 1549 | 207718_x_at | -0.2444 | 0.2226 | |
| GSE20347 | CYP2A7 | 1549 | 207718_x_at | -0.0045 | 0.9744 | |
| GSE23400 | CYP2A7 | 1549 | 207718_x_at | -0.2796 | 0.0000 | |
| GSE26886 | CYP2A7 | 1549 | 207718_x_at | -0.2348 | 0.1720 | |
| GSE29001 | CYP2A7 | 1549 | 207718_x_at | -0.2093 | 0.3690 | |
| GSE38129 | CYP2A7 | 1549 | 207718_x_at | -0.1619 | 0.1471 | |
| GSE45670 | CYP2A7 | 1549 | 207718_x_at | 0.0701 | 0.6139 | |
| GSE53622 | CYP2A7 | 1549 | 48704 | 0.0173 | 0.9316 | |
| GSE53624 | CYP2A7 | 1549 | 48704 | -0.5852 | 0.0000 | |
| GSE63941 | CYP2A7 | 1549 | 207718_x_at | -0.0186 | 0.9177 | |
| GSE77861 | CYP2A7 | 1549 | 207718_x_at | -0.0102 | 0.9563 | |
| GSE97050 | CYP2A7 | 1549 | A_23_P27528 | -0.0466 | 0.8438 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CYP2A7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CYP2A7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CYP2A7 | 1549 | 4 | 5 | 21 | |
| GSE20123 | CYP2A7 | 1549 | 4 | 4 | 22 | |
| GSE43470 | CYP2A7 | 1549 | 3 | 11 | 29 | |
| GSE46452 | CYP2A7 | 1549 | 48 | 1 | 10 | |
| GSE47630 | CYP2A7 | 1549 | 9 | 5 | 26 | |
| GSE54993 | CYP2A7 | 1549 | 17 | 4 | 49 | |
| GSE54994 | CYP2A7 | 1549 | 6 | 11 | 36 | |
| GSE60625 | CYP2A7 | 1549 | 9 | 0 | 2 | |
| GSE74703 | CYP2A7 | 1549 | 3 | 7 | 26 | |
| GSE74704 | CYP2A7 | 1549 | 4 | 2 | 14 | |
| TCGA | CYP2A7 | 1549 | 14 | 16 | 66 |
Total number of gains: 121; Total number of losses: 66; Total Number of normals: 301.
Somatic mutations of CYP2A7:
Generating mutation plots.
Highly correlated genes for CYP2A7:
Showing top 20/797 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CYP2A7 | CIITA | 0.790377 | 5 | 0 | 5 |
| CYP2A7 | DAB1 | 0.781156 | 4 | 0 | 4 |
| CYP2A7 | CCDC87 | 0.748883 | 4 | 0 | 4 |
| CYP2A7 | GABRB2 | 0.744215 | 4 | 0 | 4 |
| CYP2A7 | ART1 | 0.738893 | 5 | 0 | 5 |
| CYP2A7 | ODF1 | 0.728895 | 7 | 0 | 7 |
| CYP2A7 | RABEP2 | 0.71968 | 3 | 0 | 3 |
| CYP2A7 | CHRNA6 | 0.717779 | 3 | 0 | 3 |
| CYP2A7 | CHST4 | 0.715261 | 5 | 0 | 4 |
| CYP2A7 | GALNT8 | 0.711923 | 4 | 0 | 4 |
| CYP2A7 | KHDRBS2 | 0.711847 | 5 | 0 | 4 |
| CYP2A7 | SMR3B | 0.711636 | 6 | 0 | 6 |
| CYP2A7 | PTPRN2 | 0.710793 | 4 | 0 | 3 |
| CYP2A7 | CA7 | 0.70242 | 6 | 0 | 5 |
| CYP2A7 | SERPINA4 | 0.701172 | 5 | 0 | 5 |
| CYP2A7 | SAMD15 | 0.699811 | 4 | 0 | 4 |
| CYP2A7 | KRTAP5-9 | 0.6977 | 4 | 0 | 4 |
| CYP2A7 | NCR2 | 0.696114 | 6 | 0 | 6 |
| CYP2A7 | SLC6A12 | 0.691432 | 5 | 0 | 4 |
| CYP2A7 | DENND1C | 0.689675 | 3 | 0 | 3 |
For details and further investigation, click here
