| Full name: RUNX1 partner transcriptional co-repressor 1 | Alias Symbol: CDR|ETO|MTG8|ZMYND2 | ||
| Type: protein-coding gene | Cytoband: 8q21.3 | ||
| Entrez ID: 862 | HGNC ID: HGNC:1535 | Ensembl Gene: ENSG00000079102 | OMIM ID: 133435 |
| Drug and gene relationship at DGIdb | |||
RUNX1T1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05200 | Pathways in cancer | |
| hsa05221 | Acute myeloid leukemia |
Expression of RUNX1T1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RUNX1T1 | 862 | 205529_s_at | -1.3802 | 0.1008 | |
| GSE20347 | RUNX1T1 | 862 | 205529_s_at | -0.1186 | 0.6406 | |
| GSE23400 | RUNX1T1 | 862 | 216832_at | -0.1097 | 0.0385 | |
| GSE26886 | RUNX1T1 | 862 | 228827_at | -0.0940 | 0.8466 | |
| GSE29001 | RUNX1T1 | 862 | 216832_at | -0.0953 | 0.6135 | |
| GSE38129 | RUNX1T1 | 862 | 205529_s_at | -0.6216 | 0.0620 | |
| GSE45670 | RUNX1T1 | 862 | 228827_at | -2.2507 | 0.0003 | |
| GSE53622 | RUNX1T1 | 862 | 100055 | -0.8610 | 0.0000 | |
| GSE53624 | RUNX1T1 | 862 | 100055 | -0.7506 | 0.0000 | |
| GSE63941 | RUNX1T1 | 862 | 216832_at | -0.0600 | 0.6973 | |
| GSE77861 | RUNX1T1 | 862 | 216832_at | -0.0069 | 0.9712 | |
| GSE97050 | RUNX1T1 | 862 | A_23_P216307 | -1.0847 | 0.1187 | |
| SRP007169 | RUNX1T1 | 862 | RNAseq | 1.6437 | 0.0793 | |
| SRP064894 | RUNX1T1 | 862 | RNAseq | -0.0638 | 0.8741 | |
| SRP133303 | RUNX1T1 | 862 | RNAseq | -0.6791 | 0.0536 | |
| SRP159526 | RUNX1T1 | 862 | RNAseq | -0.5812 | 0.3019 | |
| SRP193095 | RUNX1T1 | 862 | RNAseq | 0.5132 | 0.0593 | |
| SRP219564 | RUNX1T1 | 862 | RNAseq | -0.0300 | 0.9710 | |
| TCGA | RUNX1T1 | 862 | RNAseq | -0.7829 | 0.0056 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by RUNX1T1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RUNX1T1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RUNX1T1 | 862 | 14 | 1 | 15 | |
| GSE20123 | RUNX1T1 | 862 | 15 | 1 | 14 | |
| GSE43470 | RUNX1T1 | 862 | 20 | 1 | 22 | |
| GSE46452 | RUNX1T1 | 862 | 22 | 0 | 37 | |
| GSE47630 | RUNX1T1 | 862 | 24 | 0 | 16 | |
| GSE54993 | RUNX1T1 | 862 | 0 | 20 | 50 | |
| GSE54994 | RUNX1T1 | 862 | 33 | 1 | 19 | |
| GSE60625 | RUNX1T1 | 862 | 0 | 4 | 7 | |
| GSE74703 | RUNX1T1 | 862 | 17 | 1 | 18 | |
| GSE74704 | RUNX1T1 | 862 | 10 | 0 | 10 | |
| TCGA | RUNX1T1 | 862 | 55 | 1 | 40 |
Total number of gains: 210; Total number of losses: 30; Total Number of normals: 248.
Somatic mutations of RUNX1T1:
Generating mutation plots.
Highly correlated genes for RUNX1T1:
Showing top 20/1066 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RUNX1T1 | MSRB3 | 0.858775 | 5 | 0 | 5 |
| RUNX1T1 | DDR2 | 0.848652 | 8 | 0 | 8 |
| RUNX1T1 | TNFSF12 | 0.83353 | 3 | 0 | 3 |
| RUNX1T1 | JAM3 | 0.820418 | 8 | 0 | 8 |
| RUNX1T1 | TMEM47 | 0.818628 | 8 | 0 | 8 |
| RUNX1T1 | ZEB1 | 0.817802 | 3 | 0 | 3 |
| RUNX1T1 | JAM2 | 0.812744 | 8 | 0 | 8 |
| RUNX1T1 | AOC3 | 0.798005 | 8 | 0 | 8 |
| RUNX1T1 | CCDC80 | 0.796238 | 6 | 0 | 6 |
| RUNX1T1 | MAGI2-AS3 | 0.795162 | 6 | 0 | 6 |
| RUNX1T1 | SMIM10 | 0.794453 | 4 | 0 | 4 |
| RUNX1T1 | ABCA6 | 0.787448 | 8 | 0 | 8 |
| RUNX1T1 | BNC2 | 0.784052 | 8 | 0 | 7 |
| RUNX1T1 | FBLN1 | 0.782582 | 7 | 0 | 7 |
| RUNX1T1 | RCAN2 | 0.781772 | 8 | 0 | 8 |
| RUNX1T1 | COX7A1 | 0.780724 | 7 | 0 | 7 |
| RUNX1T1 | FOXF1 | 0.776863 | 8 | 0 | 8 |
| RUNX1T1 | PDLIM3 | 0.776697 | 8 | 0 | 8 |
| RUNX1T1 | DCHS1 | 0.776617 | 5 | 0 | 4 |
| RUNX1T1 | LRFN5 | 0.774318 | 5 | 0 | 5 |
For details and further investigation, click here
