| Full name: matrix metallopeptidase 19 | Alias Symbol: RASI-1 | ||
| Type: protein-coding gene | Cytoband: 12q13.2 | ||
| Entrez ID: 4327 | HGNC ID: HGNC:7165 | Ensembl Gene: ENSG00000123342 | OMIM ID: 601807 |
| Drug and gene relationship at DGIdb | |||
Expression of MMP19:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MMP19 | 4327 | 204575_s_at | 0.7451 | 0.3103 | |
| GSE20347 | MMP19 | 4327 | 204574_s_at | 0.0126 | 0.9386 | |
| GSE23400 | MMP19 | 4327 | 204574_s_at | -0.1143 | 0.0012 | |
| GSE26886 | MMP19 | 4327 | 204574_s_at | -0.0055 | 0.9726 | |
| GSE29001 | MMP19 | 4327 | 204574_s_at | -0.0752 | 0.7042 | |
| GSE38129 | MMP19 | 4327 | 204574_s_at | -0.1768 | 0.1054 | |
| GSE45670 | MMP19 | 4327 | 204574_s_at | -0.0874 | 0.3542 | |
| GSE53622 | MMP19 | 4327 | 14180 | 0.2422 | 0.0000 | |
| GSE53624 | MMP19 | 4327 | 67971 | 0.1364 | 0.0526 | |
| GSE63941 | MMP19 | 4327 | 204574_s_at | 0.1343 | 0.4279 | |
| GSE77861 | MMP19 | 4327 | 204574_s_at | -0.1389 | 0.2640 | |
| GSE97050 | MMP19 | 4327 | A_23_P203888 | 0.1102 | 0.6966 | |
| SRP007169 | MMP19 | 4327 | RNAseq | 3.1442 | 0.0001 | |
| SRP008496 | MMP19 | 4327 | RNAseq | 3.6465 | 0.0000 | |
| SRP064894 | MMP19 | 4327 | RNAseq | 1.1949 | 0.0009 | |
| SRP133303 | MMP19 | 4327 | RNAseq | 0.9826 | 0.0121 | |
| SRP159526 | MMP19 | 4327 | RNAseq | 0.1584 | 0.7368 | |
| SRP193095 | MMP19 | 4327 | RNAseq | 2.1053 | 0.0000 | |
| SRP219564 | MMP19 | 4327 | RNAseq | 0.6752 | 0.3908 | |
| TCGA | MMP19 | 4327 | RNAseq | -0.2741 | 0.0014 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by MMP19 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MMP19:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MMP19 | 4327 | 6 | 2 | 22 | |
| GSE20123 | MMP19 | 4327 | 6 | 1 | 23 | |
| GSE43470 | MMP19 | 4327 | 4 | 0 | 39 | |
| GSE46452 | MMP19 | 4327 | 8 | 1 | 50 | |
| GSE47630 | MMP19 | 4327 | 10 | 2 | 28 | |
| GSE54993 | MMP19 | 4327 | 0 | 5 | 65 | |
| GSE54994 | MMP19 | 4327 | 4 | 1 | 48 | |
| GSE60625 | MMP19 | 4327 | 0 | 0 | 11 | |
| GSE74703 | MMP19 | 4327 | 4 | 0 | 32 | |
| GSE74704 | MMP19 | 4327 | 4 | 1 | 15 | |
| TCGA | MMP19 | 4327 | 15 | 10 | 71 |
Total number of gains: 61; Total number of losses: 23; Total Number of normals: 404.
Somatic mutations of MMP19:
Generating mutation plots.
Highly correlated genes for MMP19:
Showing top 20/989 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MMP19 | ADAMTS2 | 0.821767 | 3 | 0 | 3 |
| MMP19 | DCDC1 | 0.769342 | 3 | 0 | 3 |
| MMP19 | SLC39A5 | 0.768245 | 4 | 0 | 4 |
| MMP19 | SUN5 | 0.755878 | 4 | 0 | 4 |
| MMP19 | OR2T27 | 0.725658 | 3 | 0 | 3 |
| MMP19 | CIITA | 0.724661 | 4 | 0 | 4 |
| MMP19 | PRODH2 | 0.714324 | 6 | 0 | 5 |
| MMP19 | SIGLEC7 | 0.710371 | 8 | 0 | 6 |
| MMP19 | RASL10B | 0.709492 | 4 | 0 | 4 |
| MMP19 | OR2A5 | 0.703606 | 3 | 0 | 3 |
| MMP19 | RUNX2 | 0.700724 | 5 | 0 | 5 |
| MMP19 | TRIM43 | 0.699117 | 3 | 0 | 3 |
| MMP19 | CDC42EP2 | 0.698294 | 3 | 0 | 3 |
| MMP19 | CA7 | 0.697538 | 5 | 0 | 5 |
| MMP19 | CCL26 | 0.696535 | 3 | 0 | 3 |
| MMP19 | PABPN1L | 0.694021 | 3 | 0 | 3 |
| MMP19 | BBC3 | 0.690475 | 3 | 0 | 3 |
| MMP19 | CHMP6 | 0.688888 | 3 | 0 | 3 |
| MMP19 | FURIN | 0.688639 | 3 | 0 | 3 |
| MMP19 | DKK2 | 0.688602 | 3 | 0 | 3 |
For details and further investigation, click here
