| Full name: chloride voltage-gated channel Kb | Alias Symbol: hClC-Kb | ||
| Type: protein-coding gene | Cytoband: 1p36.13 | ||
| Entrez ID: 1188 | HGNC ID: HGNC:2027 | Ensembl Gene: ENSG00000184908 | OMIM ID: 602023 |
| Drug and gene relationship at DGIdb | |||
Expression of CLCNKB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CLCNKB | 1188 | 1554749_s_at | 0.0871 | 0.6260 | |
| GSE20347 | CLCNKB | 1188 | 205985_x_at | -0.1220 | 0.1591 | |
| GSE23400 | CLCNKB | 1188 | 205985_x_at | -0.1077 | 0.0046 | |
| GSE26886 | CLCNKB | 1188 | 1554748_at | 0.2922 | 0.0430 | |
| GSE29001 | CLCNKB | 1188 | 205985_x_at | -0.1773 | 0.1251 | |
| GSE38129 | CLCNKB | 1188 | 205985_x_at | -0.1310 | 0.2117 | |
| GSE45670 | CLCNKB | 1188 | 1554749_s_at | 0.0811 | 0.4179 | |
| GSE53622 | CLCNKB | 1188 | 69328 | -0.1773 | 0.0725 | |
| GSE53624 | CLCNKB | 1188 | 69328 | 0.0085 | 0.9221 | |
| GSE63941 | CLCNKB | 1188 | 1554749_s_at | 0.1055 | 0.5116 | |
| GSE77861 | CLCNKB | 1188 | 1554748_at | -0.1044 | 0.2941 | |
| GSE97050 | CLCNKB | 1188 | A_24_P224966 | -0.2432 | 0.4681 | |
| TCGA | CLCNKB | 1188 | RNAseq | -3.4715 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by CLCNKB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CLCNKB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CLCNKB | 1188 | 1 | 5 | 24 | |
| GSE20123 | CLCNKB | 1188 | 1 | 4 | 25 | |
| GSE43470 | CLCNKB | 1188 | 1 | 8 | 34 | |
| GSE46452 | CLCNKB | 1188 | 7 | 1 | 51 | |
| GSE47630 | CLCNKB | 1188 | 8 | 3 | 29 | |
| GSE54993 | CLCNKB | 1188 | 3 | 1 | 66 | |
| GSE54994 | CLCNKB | 1188 | 10 | 4 | 39 | |
| GSE60625 | CLCNKB | 1188 | 0 | 0 | 11 | |
| GSE74703 | CLCNKB | 1188 | 1 | 5 | 30 | |
| GSE74704 | CLCNKB | 1188 | 1 | 0 | 19 | |
| TCGA | CLCNKB | 1188 | 12 | 23 | 61 |
Total number of gains: 45; Total number of losses: 54; Total Number of normals: 389.
Somatic mutations of CLCNKB:
Generating mutation plots.
Highly correlated genes for CLCNKB:
Showing top 20/662 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CLCNKB | ANKLE1 | 0.84989 | 3 | 0 | 3 |
| CLCNKB | FAM71A | 0.834121 | 3 | 0 | 3 |
| CLCNKB | GH1 | 0.78616 | 3 | 0 | 3 |
| CLCNKB | PFN4 | 0.765105 | 3 | 0 | 3 |
| CLCNKB | PRAMEF12 | 0.758013 | 3 | 0 | 3 |
| CLCNKB | KIRREL2 | 0.750101 | 3 | 0 | 3 |
| CLCNKB | CD300LG | 0.73382 | 3 | 0 | 3 |
| CLCNKB | BRINP2 | 0.732692 | 3 | 0 | 3 |
| CLCNKB | TMEM221 | 0.732404 | 3 | 0 | 3 |
| CLCNKB | MAPK15 | 0.728601 | 3 | 0 | 3 |
| CLCNKB | CRYBA4 | 0.72808 | 4 | 0 | 4 |
| CLCNKB | JSRP1 | 0.724766 | 3 | 0 | 3 |
| CLCNKB | LY6H | 0.724313 | 3 | 0 | 3 |
| CLCNKB | IFNA4 | 0.723281 | 3 | 0 | 3 |
| CLCNKB | ZMYND15 | 0.720252 | 3 | 0 | 3 |
| CLCNKB | RASL10B | 0.719125 | 3 | 0 | 3 |
| CLCNKB | ASMT | 0.716983 | 4 | 0 | 4 |
| CLCNKB | CALCR | 0.716272 | 3 | 0 | 3 |
| CLCNKB | SLC26A1 | 0.715508 | 5 | 0 | 4 |
| CLCNKB | NAT14 | 0.7129 | 3 | 0 | 3 |
For details and further investigation, click here
