CRYBA4

 

Full name: crystallin beta A4 Alias Symbol: 
Type: protein-coding gene Cytoband: 22q12.1
Entrez ID: 1413 HGNC ID: HGNC:2396 Ensembl Gene: ENSG00000196431 OMIM ID: 123631
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of CRYBA4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CRYBA4 1413 206843_at 0.0186 0.9599
GSE20347 CRYBA4 1413 206843_at -0.0588 0.4111
GSE23400 CRYBA4 1413 206843_at -0.1732 0.0000
GSE26886 CRYBA4 1413 206843_at 0.0969 0.4497
GSE29001 CRYBA4 1413 206843_at -0.1164 0.2730
GSE38129 CRYBA4 1413 206843_at -0.1388 0.0484
GSE45670 CRYBA4 1413 206843_at -0.0120 0.9378
GSE53622 CRYBA4 1413 75728 -0.0302 0.7434
GSE53624 CRYBA4 1413 75728 -0.0908 0.2421
GSE63941 CRYBA4 1413 206843_at 0.0368 0.8264
GSE77861 CRYBA4 1413 206843_at -0.1130 0.2520

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by CRYBA4 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CRYBA4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CRYBA4 1413 3 5 22
GSE20123 CRYBA4 1413 3 4 23
GSE43470 CRYBA4 1413 4 6 33
GSE46452 CRYBA4 1413 31 1 27
GSE47630 CRYBA4 1413 8 5 27
GSE54993 CRYBA4 1413 3 6 61
GSE54994 CRYBA4 1413 11 8 34
GSE60625 CRYBA4 1413 5 0 6
GSE74703 CRYBA4 1413 3 5 28
GSE74704 CRYBA4 1413 0 1 19
TCGA CRYBA4 1413 26 14 56

Total number of gains: 97; Total number of losses: 55; Total Number of normals: 336.  

 

Somatic mutations of CRYBA4:

 

Generating mutation plots.

 

Highly correlated genes for CRYBA4:

 

Showing top 20/565 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CRYBA4CLCNKB0.72808404
CRYBA4RNF170.683337303
CRYBA4NAT20.682371303
CRYBA4THRB0.68197303
CRYBA4TSPO20.681158403
CRYBA4PRODH20.669251404
CRYBA4RCVRN0.668279403
CRYBA4CST80.662408505
CRYBA4FGF60.660965403
CRYBA4HCG90.660004404
CRYBA4HRH30.656967404
CRYBA4OR2J20.656268404
CRYBA4RASL10A0.649307303
CRYBA4SCGN0.645763303
CRYBA4DKK40.644417303
CRYBA4SLC5A50.642288403
CRYBA4KSR10.640453303
CRYBA4MTAP0.640438404
CRYBA4LRTM10.640323303
CRYBA4C11orf160.639718404

For details and further investigation, click here