| Full name: ankyrin repeat and LEM domain containing 1 | Alias Symbol: FLJ39369|LEMD6 | ||
| Type: protein-coding gene | Cytoband: 19p13.11 | ||
| Entrez ID: 126549 | HGNC ID: HGNC:26812 | Ensembl Gene: ENSG00000160117 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of ANKLE1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ANKLE1 | 126549 | 1553138_a_at | 0.2065 | 0.3298 | |
| GSE26886 | ANKLE1 | 126549 | 1553138_a_at | -0.0054 | 0.9562 | |
| GSE45670 | ANKLE1 | 126549 | 1553138_a_at | 0.1369 | 0.1336 | |
| GSE53622 | ANKLE1 | 126549 | 12993 | 0.1278 | 0.0355 | |
| GSE53624 | ANKLE1 | 126549 | 24412 | 0.6483 | 0.0000 | |
| GSE63941 | ANKLE1 | 126549 | 1553138_a_at | 0.1359 | 0.3395 | |
| GSE77861 | ANKLE1 | 126549 | 1553138_a_at | -0.0669 | 0.5430 | |
| GSE97050 | ANKLE1 | 126549 | A_33_P3252099 | -0.2691 | 0.4534 | |
| SRP007169 | ANKLE1 | 126549 | RNAseq | -0.0745 | 0.9289 | |
| SRP064894 | ANKLE1 | 126549 | RNAseq | -0.1834 | 0.4047 | |
| SRP133303 | ANKLE1 | 126549 | RNAseq | -0.1106 | 0.1959 | |
| SRP159526 | ANKLE1 | 126549 | RNAseq | 0.6605 | 0.2639 | |
| SRP193095 | ANKLE1 | 126549 | RNAseq | 0.0539 | 0.7229 | |
| SRP219564 | ANKLE1 | 126549 | RNAseq | 0.3068 | 0.5383 | |
| TCGA | ANKLE1 | 126549 | RNAseq | 1.1053 | 0.0016 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by ANKLE1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ANKLE1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ANKLE1 | 126549 | 4 | 4 | 22 | |
| GSE20123 | ANKLE1 | 126549 | 3 | 2 | 25 | |
| GSE43470 | ANKLE1 | 126549 | 2 | 6 | 35 | |
| GSE46452 | ANKLE1 | 126549 | 47 | 1 | 11 | |
| GSE47630 | ANKLE1 | 126549 | 4 | 8 | 28 | |
| GSE54993 | ANKLE1 | 126549 | 15 | 4 | 51 | |
| GSE54994 | ANKLE1 | 126549 | 6 | 14 | 33 | |
| GSE60625 | ANKLE1 | 126549 | 9 | 0 | 2 | |
| GSE74703 | ANKLE1 | 126549 | 2 | 4 | 30 | |
| GSE74704 | ANKLE1 | 126549 | 0 | 2 | 18 | |
| TCGA | ANKLE1 | 126549 | 17 | 9 | 70 |
Total number of gains: 109; Total number of losses: 54; Total Number of normals: 325.
Somatic mutations of ANKLE1:
Generating mutation plots.
Highly correlated genes for ANKLE1:
Showing top 20/103 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ANKLE1 | CLCNKB | 0.84989 | 3 | 0 | 3 |
| ANKLE1 | ZNF341 | 0.78429 | 3 | 0 | 3 |
| ANKLE1 | APBA2 | 0.763014 | 3 | 0 | 3 |
| ANKLE1 | NFYA | 0.718457 | 3 | 0 | 3 |
| ANKLE1 | SLC25A47 | 0.71558 | 3 | 0 | 3 |
| ANKLE1 | RRP1 | 0.713726 | 3 | 0 | 3 |
| ANKLE1 | NAT8B | 0.700114 | 3 | 0 | 3 |
| ANKLE1 | HOTAIR | 0.697737 | 3 | 0 | 3 |
| ANKLE1 | GABRB1 | 0.695563 | 3 | 0 | 3 |
| ANKLE1 | ZNF646 | 0.692207 | 3 | 0 | 3 |
| ANKLE1 | TDRD9 | 0.690221 | 3 | 0 | 3 |
| ANKLE1 | GMIP | 0.689804 | 3 | 0 | 3 |
| ANKLE1 | PGBD2 | 0.687661 | 3 | 0 | 3 |
| ANKLE1 | TEX22 | 0.686467 | 4 | 0 | 3 |
| ANKLE1 | WDR90 | 0.679914 | 3 | 0 | 3 |
| ANKLE1 | OPRD1 | 0.678788 | 3 | 0 | 3 |
| ANKLE1 | IL22RA2 | 0.672956 | 4 | 0 | 3 |
| ANKLE1 | GPRIN1 | 0.664784 | 3 | 0 | 3 |
| ANKLE1 | OR2T1 | 0.663456 | 3 | 0 | 3 |
| ANKLE1 | PDCD11 | 0.661862 | 3 | 0 | 3 |
For details and further investigation, click here
