| Full name: claudin 14 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 21q22.13 | ||
| Entrez ID: 23562 | HGNC ID: HGNC:2035 | Ensembl Gene: ENSG00000159261 | OMIM ID: 605608 |
| Drug and gene relationship at DGIdb | |||
CLDN14 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04530 | Tight junction |
Expression of CLDN14:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CLDN14 | 23562 | 210689_at | -0.0232 | 0.9484 | |
| GSE20347 | CLDN14 | 23562 | 210689_at | -0.0895 | 0.0867 | |
| GSE23400 | CLDN14 | 23562 | 210689_at | -0.0777 | 0.0009 | |
| GSE26886 | CLDN14 | 23562 | 210689_at | 0.2599 | 0.0132 | |
| GSE29001 | CLDN14 | 23562 | 210689_at | -0.0830 | 0.4365 | |
| GSE38129 | CLDN14 | 23562 | 210689_at | -0.0586 | 0.3119 | |
| GSE45670 | CLDN14 | 23562 | 210689_at | 0.0621 | 0.6250 | |
| GSE63941 | CLDN14 | 23562 | 210689_at | 0.1804 | 0.3218 | |
| GSE77861 | CLDN14 | 23562 | 210689_at | 0.0043 | 0.9741 | |
| GSE97050 | CLDN14 | 23562 | A_23_P91512 | 0.3134 | 0.1965 | |
| TCGA | CLDN14 | 23562 | RNAseq | 1.0868 | 0.0122 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by CLDN14 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of CLDN14:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CLDN14 | 23562 | 2 | 8 | 20 | |
| GSE20123 | CLDN14 | 23562 | 2 | 9 | 19 | |
| GSE43470 | CLDN14 | 23562 | 1 | 11 | 31 | |
| GSE46452 | CLDN14 | 23562 | 1 | 21 | 37 | |
| GSE47630 | CLDN14 | 23562 | 6 | 17 | 17 | |
| GSE54993 | CLDN14 | 23562 | 8 | 1 | 61 | |
| GSE54994 | CLDN14 | 23562 | 2 | 9 | 42 | |
| GSE60625 | CLDN14 | 23562 | 0 | 0 | 11 | |
| GSE74703 | CLDN14 | 23562 | 1 | 8 | 27 | |
| GSE74704 | CLDN14 | 23562 | 1 | 6 | 13 | |
| TCGA | CLDN14 | 23562 | 9 | 39 | 48 |
Total number of gains: 33; Total number of losses: 129; Total Number of normals: 326.
Somatic mutations of CLDN14:
Generating mutation plots.
Highly correlated genes for CLDN14:
Showing top 20/410 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CLDN14 | C10orf91 | 0.81262 | 3 | 0 | 3 |
| CLDN14 | TMEM102 | 0.780247 | 3 | 0 | 3 |
| CLDN14 | FAM171A2 | 0.778015 | 3 | 0 | 3 |
| CLDN14 | DNAJC22 | 0.766991 | 3 | 0 | 3 |
| CLDN14 | CCDC42 | 0.751849 | 3 | 0 | 3 |
| CLDN14 | CIB3 | 0.749419 | 3 | 0 | 3 |
| CLDN14 | SHANK1 | 0.7475 | 3 | 0 | 3 |
| CLDN14 | DNAJC5B | 0.746381 | 3 | 0 | 3 |
| CLDN14 | GUCY2C | 0.744149 | 3 | 0 | 3 |
| CLDN14 | PALM3 | 0.742176 | 3 | 0 | 3 |
| CLDN14 | FBXO44 | 0.737971 | 3 | 0 | 3 |
| CLDN14 | BPIFB4 | 0.73431 | 3 | 0 | 3 |
| CLDN14 | CACNG8 | 0.732444 | 3 | 0 | 3 |
| CLDN14 | CCDC28B | 0.731692 | 4 | 0 | 4 |
| CLDN14 | TMEM86A | 0.731535 | 3 | 0 | 3 |
| CLDN14 | PRRG3 | 0.725857 | 4 | 0 | 4 |
| CLDN14 | NLRP5 | 0.724874 | 4 | 0 | 4 |
| CLDN14 | KCNJ13 | 0.723616 | 4 | 0 | 3 |
| CLDN14 | CORT | 0.72336 | 4 | 0 | 3 |
| CLDN14 | SLCO1A2 | 0.721539 | 3 | 0 | 3 |
For details and further investigation, click here
