| Full name: calcium voltage-gated channel auxiliary subunit gamma 8 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 19q13.42 | ||
| Entrez ID: 59283 | HGNC ID: HGNC:13628 | Ensembl Gene: ENSG00000142408 | OMIM ID: 606900 |
| Drug and gene relationship at DGIdb | |||
CACNG8 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway | |
| hsa04261 | Adrenergic signaling in cardiomyocytes | |
| hsa04921 | Oxytocin signaling pathway |
Expression of CACNG8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CACNG8 | 59283 | 231355_at | -0.1611 | 0.5754 | |
| GSE26886 | CACNG8 | 59283 | 231355_at | 0.0064 | 0.9654 | |
| GSE45670 | CACNG8 | 59283 | 231355_at | -0.0476 | 0.5894 | |
| GSE53622 | CACNG8 | 59283 | 16488 | 0.4510 | 0.0012 | |
| GSE53624 | CACNG8 | 59283 | 16488 | -0.0228 | 0.8326 | |
| GSE63941 | CACNG8 | 59283 | 231355_at | 0.1158 | 0.4412 | |
| GSE77861 | CACNG8 | 59283 | 231355_at | -0.0842 | 0.4208 | |
| GSE97050 | CACNG8 | 59283 | A_23_P420218 | 0.0423 | 0.8469 | |
| SRP064894 | CACNG8 | 59283 | RNAseq | 0.5102 | 0.0536 | |
| SRP133303 | CACNG8 | 59283 | RNAseq | -0.0014 | 0.9913 | |
| SRP159526 | CACNG8 | 59283 | RNAseq | 0.6400 | 0.2850 | |
| SRP193095 | CACNG8 | 59283 | RNAseq | 0.0345 | 0.8210 | |
| SRP219564 | CACNG8 | 59283 | RNAseq | 0.0902 | 0.7782 | |
| TCGA | CACNG8 | 59283 | RNAseq | 0.5779 | 0.6236 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CACNG8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CACNG8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CACNG8 | 59283 | 3 | 4 | 23 | |
| GSE20123 | CACNG8 | 59283 | 3 | 3 | 24 | |
| GSE43470 | CACNG8 | 59283 | 2 | 11 | 30 | |
| GSE46452 | CACNG8 | 59283 | 45 | 1 | 13 | |
| GSE47630 | CACNG8 | 59283 | 8 | 6 | 26 | |
| GSE54993 | CACNG8 | 59283 | 17 | 4 | 49 | |
| GSE54994 | CACNG8 | 59283 | 4 | 14 | 35 | |
| GSE60625 | CACNG8 | 59283 | 9 | 0 | 2 | |
| GSE74703 | CACNG8 | 59283 | 2 | 7 | 27 | |
| GSE74704 | CACNG8 | 59283 | 3 | 1 | 16 | |
| TCGA | CACNG8 | 59283 | 19 | 15 | 62 |
Total number of gains: 115; Total number of losses: 66; Total Number of normals: 307.
Somatic mutations of CACNG8:
Generating mutation plots.
Highly correlated genes for CACNG8:
Showing top 20/315 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CACNG8 | FCN3 | 0.779637 | 3 | 0 | 3 |
| CACNG8 | CACNG4 | 0.759837 | 3 | 0 | 3 |
| CACNG8 | GPR78 | 0.747594 | 3 | 0 | 3 |
| CACNG8 | SHD | 0.741916 | 3 | 0 | 3 |
| CACNG8 | ADAMTS13 | 0.741769 | 3 | 0 | 3 |
| CACNG8 | PCDH1 | 0.739832 | 3 | 0 | 3 |
| CACNG8 | MT3 | 0.737055 | 3 | 0 | 3 |
| CACNG8 | CLDN14 | 0.732444 | 3 | 0 | 3 |
| CACNG8 | MRGPRG | 0.729283 | 3 | 0 | 3 |
| CACNG8 | C20orf173 | 0.728705 | 5 | 0 | 5 |
| CACNG8 | NHLRC4 | 0.720314 | 3 | 0 | 3 |
| CACNG8 | CHRD | 0.720088 | 3 | 0 | 3 |
| CACNG8 | ZNF843 | 0.720039 | 3 | 0 | 3 |
| CACNG8 | OR4D2 | 0.717139 | 4 | 0 | 3 |
| CACNG8 | STRC | 0.70722 | 3 | 0 | 3 |
| CACNG8 | DCDC1 | 0.705322 | 3 | 0 | 3 |
| CACNG8 | FAM71F1 | 0.703941 | 4 | 0 | 3 |
| CACNG8 | YY2 | 0.700307 | 3 | 0 | 3 |
| CACNG8 | MAG | 0.698708 | 4 | 0 | 4 |
| CACNG8 | PIP5KL1 | 0.697364 | 3 | 0 | 3 |
For details and further investigation, click here
