| Full name: NLR family pyrin domain containing 5 | Alias Symbol: PYPAF8|MATER|PAN11|CLR19.8 | ||
| Type: protein-coding gene | Cytoband: 19q13.43 | ||
| Entrez ID: 126206 | HGNC ID: HGNC:21269 | Ensembl Gene: ENSG00000171487 | OMIM ID: 609658 |
| Drug and gene relationship at DGIdb | |||
Expression of NLRP5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NLRP5 | 126206 | 1552405_at | 0.0946 | 0.6481 | |
| GSE26886 | NLRP5 | 126206 | 1552405_at | 0.2220 | 0.0696 | |
| GSE45670 | NLRP5 | 126206 | 1552405_at | 0.1565 | 0.0405 | |
| GSE53622 | NLRP5 | 126206 | 82333 | -0.0183 | 0.7753 | |
| GSE53624 | NLRP5 | 126206 | 82333 | 0.0290 | 0.7224 | |
| GSE63941 | NLRP5 | 126206 | 1552405_at | 0.0556 | 0.7889 | |
| GSE77861 | NLRP5 | 126206 | 1552405_at | -0.0061 | 0.9644 | |
| GSE97050 | NLRP5 | 126206 | A_23_P4962 | -0.0024 | 0.9925 | |
| TCGA | NLRP5 | 126206 | RNAseq | 1.3738 | 0.5101 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by NLRP5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NLRP5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NLRP5 | 126206 | 3 | 4 | 23 | |
| GSE20123 | NLRP5 | 126206 | 3 | 3 | 24 | |
| GSE43470 | NLRP5 | 126206 | 3 | 9 | 31 | |
| GSE46452 | NLRP5 | 126206 | 45 | 1 | 13 | |
| GSE47630 | NLRP5 | 126206 | 8 | 6 | 26 | |
| GSE54993 | NLRP5 | 126206 | 17 | 4 | 49 | |
| GSE54994 | NLRP5 | 126206 | 4 | 13 | 36 | |
| GSE60625 | NLRP5 | 126206 | 9 | 0 | 2 | |
| GSE74703 | NLRP5 | 126206 | 3 | 6 | 27 | |
| GSE74704 | NLRP5 | 126206 | 3 | 1 | 16 | |
| TCGA | NLRP5 | 126206 | 19 | 15 | 62 |
Total number of gains: 117; Total number of losses: 62; Total Number of normals: 309.
Somatic mutations of NLRP5:
Generating mutation plots.
Highly correlated genes for NLRP5:
Showing top 20/170 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NLRP5 | TTBK1 | 0.797118 | 3 | 0 | 3 |
| NLRP5 | OR10W1 | 0.796814 | 3 | 0 | 3 |
| NLRP5 | EYS | 0.784238 | 3 | 0 | 3 |
| NLRP5 | OR7G2 | 0.77748 | 3 | 0 | 3 |
| NLRP5 | ZNF182 | 0.774037 | 3 | 0 | 3 |
| NLRP5 | SP8 | 0.766685 | 3 | 0 | 3 |
| NLRP5 | FAM71A | 0.764142 | 3 | 0 | 3 |
| NLRP5 | GHRHR | 0.761754 | 3 | 0 | 3 |
| NLRP5 | INSC | 0.757854 | 3 | 0 | 3 |
| NLRP5 | CELF4 | 0.74719 | 3 | 0 | 3 |
| NLRP5 | FAM71B | 0.744685 | 3 | 0 | 3 |
| NLRP5 | DCD | 0.74207 | 3 | 0 | 3 |
| NLRP5 | RIMS4 | 0.73923 | 3 | 0 | 3 |
| NLRP5 | HCRT | 0.736993 | 3 | 0 | 3 |
| NLRP5 | SEC14L3 | 0.736933 | 3 | 0 | 3 |
| NLRP5 | P2RY4 | 0.73471 | 3 | 0 | 3 |
| NLRP5 | ANXA10 | 0.72572 | 3 | 0 | 3 |
| NLRP5 | CLDN14 | 0.724874 | 4 | 0 | 4 |
| NLRP5 | PRSS38 | 0.723717 | 3 | 0 | 3 |
| NLRP5 | TM6SF2 | 0.722381 | 3 | 0 | 3 |
For details and further investigation, click here
