| Full name: guanylate cyclase 2C | Alias Symbol: STAR | ||
| Type: protein-coding gene | Cytoband: 12p12.3 | ||
| Entrez ID: 2984 | HGNC ID: HGNC:4688 | Ensembl Gene: ENSG00000070019 | OMIM ID: 601330 |
| Drug and gene relationship at DGIdb | |||
Expression of GUCY2C:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GUCY2C | 2984 | 206312_at | -0.1123 | 0.6401 | |
| GSE20347 | GUCY2C | 2984 | 206312_at | 0.0266 | 0.7198 | |
| GSE23400 | GUCY2C | 2984 | 206312_at | -0.1186 | 0.0000 | |
| GSE26886 | GUCY2C | 2984 | 206312_at | -0.1007 | 0.4497 | |
| GSE29001 | GUCY2C | 2984 | 206312_at | 0.0628 | 0.7734 | |
| GSE38129 | GUCY2C | 2984 | 206312_at | -0.0306 | 0.6403 | |
| GSE45670 | GUCY2C | 2984 | 206312_at | 0.3574 | 0.0457 | |
| GSE53622 | GUCY2C | 2984 | 16745 | -0.5511 | 0.0000 | |
| GSE53624 | GUCY2C | 2984 | 16745 | -0.6379 | 0.0000 | |
| GSE63941 | GUCY2C | 2984 | 206312_at | -0.1088 | 0.5393 | |
| GSE77861 | GUCY2C | 2984 | 206312_at | -0.1358 | 0.0806 | |
| GSE97050 | GUCY2C | 2984 | A_23_P76312 | 0.0006 | 0.9979 | |
| SRP064894 | GUCY2C | 2984 | RNAseq | -1.9024 | 0.0000 | |
| SRP133303 | GUCY2C | 2984 | RNAseq | -0.6318 | 0.0432 | |
| SRP159526 | GUCY2C | 2984 | RNAseq | -2.2558 | 0.0000 | |
| SRP193095 | GUCY2C | 2984 | RNAseq | -0.9545 | 0.0017 | |
| TCGA | GUCY2C | 2984 | RNAseq | -0.3059 | 0.4247 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by GUCY2C expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GUCY2C:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GUCY2C | 2984 | 6 | 2 | 22 | |
| GSE20123 | GUCY2C | 2984 | 6 | 2 | 22 | |
| GSE43470 | GUCY2C | 2984 | 9 | 4 | 30 | |
| GSE46452 | GUCY2C | 2984 | 10 | 1 | 48 | |
| GSE47630 | GUCY2C | 2984 | 14 | 1 | 25 | |
| GSE54993 | GUCY2C | 2984 | 1 | 9 | 60 | |
| GSE54994 | GUCY2C | 2984 | 10 | 2 | 41 | |
| GSE60625 | GUCY2C | 2984 | 0 | 1 | 10 | |
| GSE74703 | GUCY2C | 2984 | 9 | 3 | 24 | |
| GSE74704 | GUCY2C | 2984 | 4 | 1 | 15 | |
| TCGA | GUCY2C | 2984 | 40 | 6 | 50 |
Total number of gains: 109; Total number of losses: 32; Total Number of normals: 347.
Somatic mutations of GUCY2C:
Generating mutation plots.
Highly correlated genes for GUCY2C:
Showing top 20/238 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GUCY2C | DIO3 | 0.815759 | 3 | 0 | 3 |
| GUCY2C | CBLN4 | 0.766426 | 3 | 0 | 3 |
| GUCY2C | INHBC | 0.760172 | 3 | 0 | 3 |
| GUCY2C | SHD | 0.754644 | 3 | 0 | 3 |
| GUCY2C | SHC3 | 0.750596 | 3 | 0 | 3 |
| GUCY2C | CLDN14 | 0.744149 | 3 | 0 | 3 |
| GUCY2C | GIPR | 0.739388 | 3 | 0 | 3 |
| GUCY2C | FASLG | 0.733024 | 3 | 0 | 3 |
| GUCY2C | TSPAN11 | 0.727966 | 3 | 0 | 3 |
| GUCY2C | C10orf90 | 0.723132 | 3 | 0 | 3 |
| GUCY2C | GRID1 | 0.710301 | 3 | 0 | 3 |
| GUCY2C | SLC6A18 | 0.708116 | 3 | 0 | 3 |
| GUCY2C | ZSWIM3 | 0.707527 | 3 | 0 | 3 |
| GUCY2C | MOS | 0.70349 | 4 | 0 | 3 |
| GUCY2C | SMOC1 | 0.702656 | 3 | 0 | 3 |
| GUCY2C | SCOC-AS1 | 0.696402 | 3 | 0 | 3 |
| GUCY2C | LIPC | 0.690872 | 3 | 0 | 3 |
| GUCY2C | ABCC6 | 0.689431 | 3 | 0 | 3 |
| GUCY2C | ZNF821 | 0.689085 | 3 | 0 | 3 |
| GUCY2C | GPR78 | 0.688046 | 4 | 0 | 3 |
For details and further investigation, click here
