| Full name: SH3 and multiple ankyrin repeat domains 1 | Alias Symbol: SSTRIP|SPANK-1|synamon | ||
| Type: protein-coding gene | Cytoband: 19q13.33 | ||
| Entrez ID: 50944 | HGNC ID: HGNC:15474 | Ensembl Gene: ENSG00000161681 | OMIM ID: 604999 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SHANK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SHANK1 | 50944 | 220563_s_at | 0.2098 | 0.2917 | |
| GSE20347 | SHANK1 | 50944 | 220563_s_at | 0.0191 | 0.7748 | |
| GSE23400 | SHANK1 | 50944 | 220563_s_at | -0.1281 | 0.0003 | |
| GSE26886 | SHANK1 | 50944 | 220563_s_at | 0.1506 | 0.2580 | |
| GSE29001 | SHANK1 | 50944 | 220563_s_at | -0.0193 | 0.9100 | |
| GSE38129 | SHANK1 | 50944 | 220563_s_at | -0.0303 | 0.6514 | |
| GSE45670 | SHANK1 | 50944 | 220563_s_at | 0.0827 | 0.4073 | |
| GSE53622 | SHANK1 | 50944 | 58729 | 0.0989 | 0.0573 | |
| GSE53624 | SHANK1 | 50944 | 58729 | 0.2935 | 0.0000 | |
| GSE63941 | SHANK1 | 50944 | 220563_s_at | 0.1204 | 0.4030 | |
| GSE77861 | SHANK1 | 50944 | 220563_s_at | -0.1503 | 0.1266 | |
| GSE97050 | SHANK1 | 50944 | A_23_P208636 | -0.3801 | 0.1590 | |
| SRP133303 | SHANK1 | 50944 | RNAseq | 1.1241 | 0.0097 | |
| SRP219564 | SHANK1 | 50944 | RNAseq | 1.2609 | 0.0406 | |
| TCGA | SHANK1 | 50944 | RNAseq | 0.2078 | 0.5974 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by SHANK1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SHANK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SHANK1 | 50944 | 3 | 4 | 23 | |
| GSE20123 | SHANK1 | 50944 | 3 | 3 | 24 | |
| GSE43470 | SHANK1 | 50944 | 4 | 11 | 28 | |
| GSE46452 | SHANK1 | 50944 | 45 | 1 | 13 | |
| GSE47630 | SHANK1 | 50944 | 10 | 6 | 24 | |
| GSE54993 | SHANK1 | 50944 | 17 | 4 | 49 | |
| GSE54994 | SHANK1 | 50944 | 4 | 14 | 35 | |
| GSE60625 | SHANK1 | 50944 | 9 | 0 | 2 | |
| GSE74703 | SHANK1 | 50944 | 4 | 7 | 25 | |
| GSE74704 | SHANK1 | 50944 | 3 | 1 | 16 | |
| TCGA | SHANK1 | 50944 | 14 | 19 | 63 |
Total number of gains: 116; Total number of losses: 70; Total Number of normals: 302.
Somatic mutations of SHANK1:
Generating mutation plots.
Highly correlated genes for SHANK1:
Showing top 20/712 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SHANK1 | IGFN1 | 0.788942 | 3 | 0 | 3 |
| SHANK1 | ABCC6 | 0.776879 | 4 | 0 | 4 |
| SHANK1 | LCT | 0.775185 | 3 | 0 | 3 |
| SHANK1 | KCNT1 | 0.764839 | 4 | 0 | 4 |
| SHANK1 | SLC12A3 | 0.761703 | 3 | 0 | 3 |
| SHANK1 | CTSE | 0.761624 | 3 | 0 | 3 |
| SHANK1 | GPT | 0.761613 | 4 | 0 | 4 |
| SHANK1 | HOXD9 | 0.759604 | 4 | 0 | 4 |
| SHANK1 | JSRP1 | 0.755479 | 3 | 0 | 3 |
| SHANK1 | HSD17B14 | 0.754445 | 3 | 0 | 3 |
| SHANK1 | CLDN14 | 0.7475 | 3 | 0 | 3 |
| SHANK1 | CNGB3 | 0.747499 | 3 | 0 | 3 |
| SHANK1 | ZNF329 | 0.744004 | 3 | 0 | 3 |
| SHANK1 | NCAN | 0.737629 | 4 | 0 | 4 |
| SHANK1 | ZNF572 | 0.735893 | 3 | 0 | 3 |
| SHANK1 | MLXIPL | 0.735218 | 3 | 0 | 3 |
| SHANK1 | TRPM3 | 0.734975 | 4 | 0 | 4 |
| SHANK1 | RAD52 | 0.734675 | 3 | 0 | 3 |
| SHANK1 | CLEC1B | 0.732518 | 5 | 0 | 5 |
| SHANK1 | DNAJB8 | 0.729566 | 3 | 0 | 3 |
For details and further investigation, click here
