| Full name: cyclic nucleotide gated channel subunit beta 1 | Alias Symbol: RCNC2|RCNCb|GARP|GAR1|CNGB1B|RP45 | ||
| Type: protein-coding gene | Cytoband: 16q21 | ||
| Entrez ID: 1258 | HGNC ID: HGNC:2151 | Ensembl Gene: ENSG00000070729 | OMIM ID: 600724 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
CNGB1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04022 | cGMP-PKG signaling pathway | |
| hsa04024 | cAMP signaling pathway | |
| hsa04740 | Olfactory transduction |
Expression of CNGB1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CNGB1 | 1258 | 210769_at | -0.1066 | 0.6680 | |
| GSE20347 | CNGB1 | 1258 | 210769_at | -0.0246 | 0.7992 | |
| GSE23400 | CNGB1 | 1258 | 210769_at | -0.1359 | 0.0001 | |
| GSE26886 | CNGB1 | 1258 | 210769_at | 0.0527 | 0.7126 | |
| GSE29001 | CNGB1 | 1258 | 210769_at | -0.1449 | 0.2731 | |
| GSE38129 | CNGB1 | 1258 | 210769_at | -0.1446 | 0.2088 | |
| GSE45670 | CNGB1 | 1258 | 210769_at | -0.1302 | 0.2195 | |
| GSE53622 | CNGB1 | 1258 | 13804 | 0.7499 | 0.0000 | |
| GSE53624 | CNGB1 | 1258 | 13804 | 0.9559 | 0.0000 | |
| GSE63941 | CNGB1 | 1258 | 210769_at | -0.0513 | 0.7889 | |
| GSE77861 | CNGB1 | 1258 | 210769_at | -0.1749 | 0.2240 | |
| GSE97050 | CNGB1 | 1258 | A_23_P37718 | -0.0017 | 0.9965 | |
| SRP007169 | CNGB1 | 1258 | RNAseq | 1.8436 | 0.0581 | |
| SRP133303 | CNGB1 | 1258 | RNAseq | 1.2132 | 0.0000 | |
| SRP159526 | CNGB1 | 1258 | RNAseq | 1.7846 | 0.0037 | |
| SRP193095 | CNGB1 | 1258 | RNAseq | 2.7975 | 0.0000 | |
| SRP219564 | CNGB1 | 1258 | RNAseq | 1.9014 | 0.0075 | |
| TCGA | CNGB1 | 1258 | RNAseq | 2.9261 | 0.0000 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by CNGB1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CNGB1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CNGB1 | 1258 | 6 | 0 | 24 | |
| GSE20123 | CNGB1 | 1258 | 6 | 1 | 23 | |
| GSE43470 | CNGB1 | 1258 | 2 | 7 | 34 | |
| GSE46452 | CNGB1 | 1258 | 38 | 1 | 20 | |
| GSE47630 | CNGB1 | 1258 | 10 | 8 | 22 | |
| GSE54993 | CNGB1 | 1258 | 2 | 4 | 64 | |
| GSE54994 | CNGB1 | 1258 | 6 | 10 | 37 | |
| GSE60625 | CNGB1 | 1258 | 4 | 0 | 7 | |
| GSE74703 | CNGB1 | 1258 | 2 | 5 | 29 | |
| GSE74704 | CNGB1 | 1258 | 5 | 0 | 15 | |
| TCGA | CNGB1 | 1258 | 26 | 12 | 58 |
Total number of gains: 107; Total number of losses: 48; Total Number of normals: 333.
Somatic mutations of CNGB1:
Generating mutation plots.
Highly correlated genes for CNGB1:
Showing top 20/769 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CNGB1 | OR1J4 | 0.817366 | 3 | 0 | 3 |
| CNGB1 | CPNE9 | 0.768715 | 3 | 0 | 3 |
| CNGB1 | NOBOX | 0.754947 | 3 | 0 | 3 |
| CNGB1 | GPR39 | 0.747817 | 3 | 0 | 3 |
| CNGB1 | FAM171A2 | 0.736498 | 4 | 0 | 4 |
| CNGB1 | EYS | 0.735457 | 3 | 0 | 3 |
| CNGB1 | GJD4 | 0.732807 | 3 | 0 | 3 |
| CNGB1 | RASL10B | 0.732277 | 4 | 0 | 4 |
| CNGB1 | SNORA71B | 0.726106 | 3 | 0 | 3 |
| CNGB1 | OR2C3 | 0.714637 | 4 | 0 | 3 |
| CNGB1 | TMEM184A | 0.714337 | 4 | 0 | 4 |
| CNGB1 | IQCD | 0.714128 | 4 | 0 | 4 |
| CNGB1 | CDRT15 | 0.711138 | 3 | 0 | 3 |
| CNGB1 | MAGIX | 0.705492 | 3 | 0 | 3 |
| CNGB1 | WDR87 | 0.702794 | 3 | 0 | 3 |
| CNGB1 | FMR1NB | 0.701508 | 4 | 0 | 4 |
| CNGB1 | SLC22A11 | 0.701029 | 5 | 0 | 4 |
| CNGB1 | NOXA1 | 0.699347 | 5 | 0 | 5 |
| CNGB1 | ADAP1 | 0.695981 | 4 | 0 | 4 |
| CNGB1 | SPDEF | 0.694483 | 8 | 0 | 7 |
For details and further investigation, click here
