| Full name: SAM pointed domain containing ETS transcription factor | Alias Symbol: PDEF|bA375E1.3 | ||
| Type: protein-coding gene | Cytoband: 6p21.31 | ||
| Entrez ID: 25803 | HGNC ID: HGNC:17257 | Ensembl Gene: ENSG00000124664 | OMIM ID: 608144 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SPDEF:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPDEF | 25803 | 213441_x_at | -0.2205 | 0.2609 | |
| GSE20347 | SPDEF | 25803 | 213442_x_at | -0.0492 | 0.5528 | |
| GSE23400 | SPDEF | 25803 | 213441_x_at | -0.0428 | 0.2324 | |
| GSE26886 | SPDEF | 25803 | 214403_x_at | -0.0231 | 0.8683 | |
| GSE29001 | SPDEF | 25803 | 214403_x_at | -0.1057 | 0.5905 | |
| GSE38129 | SPDEF | 25803 | 214403_x_at | -0.1459 | 0.2115 | |
| GSE45670 | SPDEF | 25803 | 214403_x_at | 0.0072 | 0.9475 | |
| GSE53622 | SPDEF | 25803 | 90317 | 0.1568 | 0.3375 | |
| GSE53624 | SPDEF | 25803 | 90317 | -0.2248 | 0.0149 | |
| GSE63941 | SPDEF | 25803 | 213441_x_at | 0.0809 | 0.5547 | |
| GSE77861 | SPDEF | 25803 | 214403_x_at | -0.0163 | 0.8775 | |
| GSE97050 | SPDEF | 25803 | A_23_P111194 | 0.5448 | 0.1834 | |
| SRP133303 | SPDEF | 25803 | RNAseq | -4.1145 | 0.0000 | |
| TCGA | SPDEF | 25803 | RNAseq | -2.2815 | 0.0004 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by SPDEF expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPDEF:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPDEF | 25803 | 5 | 0 | 25 | |
| GSE20123 | SPDEF | 25803 | 5 | 0 | 25 | |
| GSE43470 | SPDEF | 25803 | 5 | 1 | 37 | |
| GSE46452 | SPDEF | 25803 | 2 | 9 | 48 | |
| GSE47630 | SPDEF | 25803 | 8 | 4 | 28 | |
| GSE54993 | SPDEF | 25803 | 3 | 1 | 66 | |
| GSE54994 | SPDEF | 25803 | 11 | 4 | 38 | |
| GSE60625 | SPDEF | 25803 | 1 | 0 | 10 | |
| GSE74703 | SPDEF | 25803 | 5 | 0 | 31 | |
| GSE74704 | SPDEF | 25803 | 2 | 0 | 18 | |
| TCGA | SPDEF | 25803 | 16 | 15 | 65 |
Total number of gains: 63; Total number of losses: 34; Total Number of normals: 391.
Somatic mutations of SPDEF:
Generating mutation plots.
Highly correlated genes for SPDEF:
Showing top 20/603 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPDEF | IGH | 0.709796 | 6 | 0 | 6 |
| SPDEF | C11orf94 | 0.70663 | 3 | 0 | 3 |
| SPDEF | CNGB1 | 0.694483 | 8 | 0 | 7 |
| SPDEF | RHBG | 0.692511 | 5 | 0 | 4 |
| SPDEF | RNF17 | 0.692108 | 3 | 0 | 3 |
| SPDEF | MASP2 | 0.678352 | 4 | 0 | 3 |
| SPDEF | MORN1 | 0.672391 | 6 | 0 | 5 |
| SPDEF | PAX3 | 0.671484 | 4 | 0 | 3 |
| SPDEF | CACNG8 | 0.668112 | 3 | 0 | 3 |
| SPDEF | GABRB3 | 0.667195 | 3 | 0 | 3 |
| SPDEF | GJD2 | 0.664279 | 4 | 0 | 3 |
| SPDEF | VRTN | 0.663909 | 7 | 0 | 7 |
| SPDEF | PRAMEF12 | 0.661855 | 4 | 0 | 4 |
| SPDEF | HAP1 | 0.660635 | 5 | 0 | 4 |
| SPDEF | PNMA3 | 0.66025 | 6 | 0 | 5 |
| SPDEF | AGR3 | 0.65964 | 4 | 0 | 4 |
| SPDEF | TP53TG5 | 0.659154 | 6 | 0 | 6 |
| SPDEF | HLA-DOA | 0.658933 | 5 | 0 | 4 |
| SPDEF | PROP1 | 0.658065 | 4 | 0 | 3 |
| SPDEF | AQP2 | 0.657472 | 5 | 0 | 4 |
For details and further investigation, click here
