| Full name: corticotropin releasing hormone | Alias Symbol: CRF|CRH1 | ||
| Type: protein-coding gene | Cytoband: 8q13.1 | ||
| Entrez ID: 1392 | HGNC ID: HGNC:2355 | Ensembl Gene: ENSG00000147571 | OMIM ID: 122560 |
| Drug and gene relationship at DGIdb | |||
CRH involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04730 | Long-term depression | |
| hsa05034 | Alcoholism |
Expression of CRH:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CRH | 1392 | 205629_s_at | 0.0384 | 0.8724 | |
| GSE20347 | CRH | 1392 | 205629_s_at | -0.0010 | 0.9900 | |
| GSE23400 | CRH | 1392 | 205630_at | -0.0337 | 0.2526 | |
| GSE26886 | CRH | 1392 | 205629_s_at | 0.0433 | 0.7515 | |
| GSE29001 | CRH | 1392 | 205629_s_at | -0.1025 | 0.5315 | |
| GSE38129 | CRH | 1392 | 205629_s_at | -0.1137 | 0.0877 | |
| GSE45670 | CRH | 1392 | 205629_s_at | -0.0470 | 0.6298 | |
| GSE53622 | CRH | 1392 | 28005 | -0.1471 | 0.2626 | |
| GSE53624 | CRH | 1392 | 28005 | -0.0977 | 0.3829 | |
| GSE63941 | CRH | 1392 | 205629_s_at | 0.2232 | 0.1231 | |
| GSE77861 | CRH | 1392 | 205629_s_at | -0.1034 | 0.3990 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CRH expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CRH:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CRH | 1392 | 13 | 1 | 16 | |
| GSE20123 | CRH | 1392 | 13 | 1 | 16 | |
| GSE43470 | CRH | 1392 | 15 | 3 | 25 | |
| GSE46452 | CRH | 1392 | 21 | 1 | 37 | |
| GSE47630 | CRH | 1392 | 23 | 1 | 16 | |
| GSE54993 | CRH | 1392 | 1 | 18 | 51 | |
| GSE54994 | CRH | 1392 | 30 | 0 | 23 | |
| GSE60625 | CRH | 1392 | 0 | 4 | 7 | |
| GSE74703 | CRH | 1392 | 13 | 2 | 21 | |
| GSE74704 | CRH | 1392 | 9 | 0 | 11 | |
| TCGA | CRH | 1392 | 49 | 5 | 42 |
Total number of gains: 187; Total number of losses: 36; Total Number of normals: 265.
Somatic mutations of CRH:
Generating mutation plots.
Highly correlated genes for CRH:
Showing top 20/745 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CRH | REG3G | 0.779201 | 3 | 0 | 3 |
| CRH | MMP17 | 0.765277 | 3 | 0 | 3 |
| CRH | ASB11 | 0.7606 | 3 | 0 | 3 |
| CRH | OR10C1 | 0.682779 | 5 | 0 | 4 |
| CRH | TEX13A | 0.679874 | 5 | 0 | 5 |
| CRH | C6 | 0.670285 | 3 | 0 | 3 |
| CRH | C10orf91 | 0.665265 | 3 | 0 | 3 |
| CRH | CBLN1 | 0.662846 | 3 | 0 | 3 |
| CRH | ZDHHC24 | 0.661735 | 3 | 0 | 3 |
| CRH | ANGPTL3 | 0.657762 | 4 | 0 | 4 |
| CRH | FABP7 | 0.657198 | 3 | 0 | 3 |
| CRH | OR2S2 | 0.655658 | 3 | 0 | 3 |
| CRH | CCDC30 | 0.649869 | 3 | 0 | 3 |
| CRH | SGCA | 0.649356 | 3 | 0 | 3 |
| CRH | FZR1 | 0.649289 | 4 | 0 | 3 |
| CRH | MUC5AC | 0.645923 | 4 | 0 | 4 |
| CRH | CSH1 | 0.643952 | 4 | 0 | 3 |
| CRH | ADM2 | 0.639438 | 6 | 0 | 5 |
| CRH | DNAI2 | 0.637792 | 4 | 0 | 3 |
| CRH | SLC38A3 | 0.636412 | 7 | 0 | 6 |
For details and further investigation, click here
