| Full name: chorionic somatomammotropin hormone 1 | Alias Symbol: hCS-A|CSA|PL|CSMT|FLJ75407 | ||
| Type: protein-coding gene | Cytoband: 17q23.3 | ||
| Entrez ID: 1442 | HGNC ID: HGNC:2440 | Ensembl Gene: ENSG00000136488 | OMIM ID: 150200 |
| Drug and gene relationship at DGIdb | |||
CSH1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04630 | Jak-STAT signaling pathway |
Expression of CSH1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CSH1 | 1442 | 208357_x_at | 0.1409 | 0.6150 | |
| GSE20347 | CSH1 | 1442 | 208357_x_at | -0.1420 | 0.0634 | |
| GSE23400 | CSH1 | 1442 | 208357_x_at | -0.1486 | 0.0001 | |
| GSE26886 | CSH1 | 1442 | 208357_x_at | -0.0151 | 0.9124 | |
| GSE29001 | CSH1 | 1442 | 208357_x_at | -0.0704 | 0.5674 | |
| GSE38129 | CSH1 | 1442 | 208357_x_at | -0.1419 | 0.0300 | |
| GSE45670 | CSH1 | 1442 | 208357_x_at | -0.1141 | 0.2921 | |
| GSE53622 | CSH1 | 1442 | 140038 | 0.0506 | 0.5671 | |
| GSE53624 | CSH1 | 1442 | 140038 | -0.2461 | 0.0048 | |
| GSE63941 | CSH1 | 1442 | 208357_x_at | -0.0422 | 0.8257 | |
| GSE77861 | CSH1 | 1442 | 208357_x_at | -0.2105 | 0.1344 | |
| GSE97050 | CSH1 | 1442 | A_24_P211044 | 0.0322 | 0.9183 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CSH1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CSH1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CSH1 | 1442 | 3 | 1 | 26 | |
| GSE20123 | CSH1 | 1442 | 3 | 1 | 26 | |
| GSE43470 | CSH1 | 1442 | 4 | 0 | 39 | |
| GSE46452 | CSH1 | 1442 | 31 | 0 | 28 | |
| GSE47630 | CSH1 | 1442 | 7 | 1 | 32 | |
| GSE54993 | CSH1 | 1442 | 2 | 5 | 63 | |
| GSE54994 | CSH1 | 1442 | 9 | 4 | 40 | |
| GSE60625 | CSH1 | 1442 | 4 | 0 | 7 | |
| GSE74703 | CSH1 | 1442 | 4 | 0 | 32 | |
| GSE74704 | CSH1 | 1442 | 3 | 1 | 16 | |
| TCGA | CSH1 | 1442 | 30 | 8 | 58 |
Total number of gains: 100; Total number of losses: 21; Total Number of normals: 367.
Somatic mutations of CSH1:
Generating mutation plots.
Highly correlated genes for CSH1:
Showing top 20/1043 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CSH1 | GLI4 | 0.786245 | 3 | 0 | 3 |
| CSH1 | STRC | 0.778042 | 3 | 0 | 3 |
| CSH1 | FAM171A2 | 0.760032 | 3 | 0 | 3 |
| CSH1 | SPANXN4 | 0.756711 | 3 | 0 | 3 |
| CSH1 | C9orf153 | 0.745353 | 3 | 0 | 3 |
| CSH1 | TTC34 | 0.732863 | 3 | 0 | 3 |
| CSH1 | LGALS12 | 0.724639 | 4 | 0 | 3 |
| CSH1 | GPR152 | 0.721667 | 3 | 0 | 3 |
| CSH1 | CLCNKA | 0.715118 | 3 | 0 | 3 |
| CSH1 | LRRC71 | 0.714013 | 3 | 0 | 3 |
| CSH1 | PLA2G2C | 0.712718 | 3 | 0 | 3 |
| CSH1 | RNF180 | 0.708781 | 4 | 0 | 4 |
| CSH1 | YY2 | 0.707942 | 3 | 0 | 3 |
| CSH1 | TOR2A | 0.704056 | 4 | 0 | 4 |
| CSH1 | TTPA | 0.703498 | 3 | 0 | 3 |
| CSH1 | PANX2 | 0.702161 | 4 | 0 | 3 |
| CSH1 | LBX2 | 0.700544 | 3 | 0 | 3 |
| CSH1 | SPACA3 | 0.700373 | 5 | 0 | 4 |
| CSH1 | CA8 | 0.698554 | 3 | 0 | 3 |
| CSH1 | KRTAP9-1 | 0.69713 | 3 | 0 | 3 |
For details and further investigation, click here
