| Full name: angiopoietin like 3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1p31.3 | ||
| Entrez ID: 27329 | HGNC ID: HGNC:491 | Ensembl Gene: ENSG00000132855 | OMIM ID: 604774 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of ANGPTL3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ANGPTL3 | 27329 | 231684_at | 0.1039 | 0.7346 | |
| GSE20347 | ANGPTL3 | 27329 | 219803_at | -0.0447 | 0.4144 | |
| GSE23400 | ANGPTL3 | 27329 | 219803_at | -0.0173 | 0.4253 | |
| GSE26886 | ANGPTL3 | 27329 | 243799_x_at | -0.0612 | 0.4084 | |
| GSE29001 | ANGPTL3 | 27329 | 219803_at | -0.0065 | 0.9617 | |
| GSE38129 | ANGPTL3 | 27329 | 219803_at | -0.1231 | 0.0805 | |
| GSE45670 | ANGPTL3 | 27329 | 231684_at | 0.0431 | 0.5475 | |
| GSE53622 | ANGPTL3 | 27329 | 43517 | -0.3439 | 0.0470 | |
| GSE53624 | ANGPTL3 | 27329 | 43517 | -0.2012 | 0.1369 | |
| GSE63941 | ANGPTL3 | 27329 | 219803_at | 0.1735 | 0.0803 | |
| GSE77861 | ANGPTL3 | 27329 | 231684_at | -0.0594 | 0.4453 | |
| GSE97050 | ANGPTL3 | 27329 | A_23_P160262 | -0.0262 | 0.9804 | |
| SRP133303 | ANGPTL3 | 27329 | RNAseq | 0.5551 | 0.0419 | |
| SRP193095 | ANGPTL3 | 27329 | RNAseq | -0.4038 | 0.0753 | |
| TCGA | ANGPTL3 | 27329 | RNAseq | -4.0671 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by ANGPTL3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ANGPTL3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ANGPTL3 | 27329 | 3 | 6 | 21 | |
| GSE20123 | ANGPTL3 | 27329 | 3 | 5 | 22 | |
| GSE43470 | ANGPTL3 | 27329 | 5 | 2 | 36 | |
| GSE46452 | ANGPTL3 | 27329 | 1 | 1 | 57 | |
| GSE47630 | ANGPTL3 | 27329 | 8 | 5 | 27 | |
| GSE54993 | ANGPTL3 | 27329 | 0 | 0 | 70 | |
| GSE54994 | ANGPTL3 | 27329 | 6 | 4 | 43 | |
| GSE60625 | ANGPTL3 | 27329 | 0 | 0 | 11 | |
| GSE74703 | ANGPTL3 | 27329 | 4 | 2 | 30 | |
| GSE74704 | ANGPTL3 | 27329 | 2 | 2 | 16 | |
| TCGA | ANGPTL3 | 27329 | 10 | 20 | 66 |
Total number of gains: 42; Total number of losses: 47; Total Number of normals: 399.
Somatic mutations of ANGPTL3:
Generating mutation plots.
Highly correlated genes for ANGPTL3:
Showing top 20/159 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ANGPTL3 | OSBP2 | 0.715269 | 3 | 0 | 3 |
| ANGPTL3 | CD101 | 0.706829 | 3 | 0 | 3 |
| ANGPTL3 | SPATA2L | 0.688516 | 3 | 0 | 3 |
| ANGPTL3 | CACTIN | 0.681408 | 3 | 0 | 3 |
| ANGPTL3 | ANAPC2 | 0.662538 | 3 | 0 | 3 |
| ANGPTL3 | FBP2 | 0.662275 | 4 | 0 | 4 |
| ANGPTL3 | CHRNB2 | 0.657998 | 3 | 0 | 3 |
| ANGPTL3 | CRH | 0.657762 | 4 | 0 | 4 |
| ANGPTL3 | DCAF15 | 0.653044 | 4 | 0 | 4 |
| ANGPTL3 | CA1 | 0.649348 | 3 | 0 | 3 |
| ANGPTL3 | NUP98 | 0.646393 | 3 | 0 | 3 |
| ANGPTL3 | CRTC1 | 0.644568 | 4 | 0 | 3 |
| ANGPTL3 | INO80B | 0.641581 | 4 | 0 | 3 |
| ANGPTL3 | ZNF81 | 0.640235 | 3 | 0 | 3 |
| ANGPTL3 | CNTD2 | 0.637075 | 4 | 0 | 4 |
| ANGPTL3 | STK11 | 0.619583 | 3 | 0 | 3 |
| ANGPTL3 | ATP4A | 0.618549 | 4 | 0 | 3 |
| ANGPTL3 | ADAM21 | 0.613723 | 3 | 0 | 3 |
| ANGPTL3 | RUNDC3A | 0.612332 | 4 | 0 | 3 |
| ANGPTL3 | CDK16 | 0.609569 | 4 | 0 | 4 |
For details and further investigation, click here
