| Full name: matrix metallopeptidase 17 | Alias Symbol: MT4-MMP | ||
| Type: protein-coding gene | Cytoband: 12q24.33 | ||
| Entrez ID: 4326 | HGNC ID: HGNC:7163 | Ensembl Gene: ENSG00000198598 | OMIM ID: 602285 |
| Drug and gene relationship at DGIdb | |||
Expression of MMP17:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MMP17 | 4326 | 206234_s_at | 0.1729 | 0.5355 | |
| GSE20347 | MMP17 | 4326 | 206234_s_at | 0.0369 | 0.6507 | |
| GSE23400 | MMP17 | 4326 | 206234_s_at | -0.0618 | 0.1579 | |
| GSE26886 | MMP17 | 4326 | 206234_s_at | 0.2264 | 0.0259 | |
| GSE29001 | MMP17 | 4326 | 206234_s_at | -0.1213 | 0.4370 | |
| GSE38129 | MMP17 | 4326 | 206234_s_at | -0.0525 | 0.4666 | |
| GSE45670 | MMP17 | 4326 | 206234_s_at | 0.1121 | 0.1609 | |
| GSE63941 | MMP17 | 4326 | 206234_s_at | 0.2289 | 0.2464 | |
| GSE77861 | MMP17 | 4326 | 206234_s_at | -0.1078 | 0.6129 | |
| GSE97050 | MMP17 | 4326 | A_23_P136413 | 0.1975 | 0.3997 | |
| SRP007169 | MMP17 | 4326 | RNAseq | 2.1193 | 0.0691 | |
| SRP064894 | MMP17 | 4326 | RNAseq | 1.5816 | 0.0000 | |
| SRP133303 | MMP17 | 4326 | RNAseq | 0.9016 | 0.0019 | |
| SRP159526 | MMP17 | 4326 | RNAseq | 1.0750 | 0.0056 | |
| SRP219564 | MMP17 | 4326 | RNAseq | 1.5427 | 0.0242 | |
| TCGA | MMP17 | 4326 | RNAseq | 0.9608 | 0.0000 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by MMP17 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of MMP17:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MMP17 | 4326 | 4 | 5 | 21 | |
| GSE20123 | MMP17 | 4326 | 4 | 5 | 21 | |
| GSE43470 | MMP17 | 4326 | 3 | 3 | 37 | |
| GSE46452 | MMP17 | 4326 | 8 | 3 | 48 | |
| GSE47630 | MMP17 | 4326 | 9 | 3 | 28 | |
| GSE54993 | MMP17 | 4326 | 0 | 6 | 64 | |
| GSE54994 | MMP17 | 4326 | 4 | 8 | 41 | |
| GSE60625 | MMP17 | 4326 | 0 | 0 | 11 | |
| GSE74703 | MMP17 | 4326 | 2 | 3 | 31 | |
| GSE74704 | MMP17 | 4326 | 2 | 3 | 15 | |
| TCGA | MMP17 | 4326 | 22 | 13 | 61 |
Total number of gains: 58; Total number of losses: 52; Total Number of normals: 378.
Somatic mutations of MMP17:
Generating mutation plots.
Highly correlated genes for MMP17:
Showing top 20/469 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MMP17 | LHX9 | 0.807835 | 3 | 0 | 3 |
| MMP17 | CRH | 0.765277 | 3 | 0 | 3 |
| MMP17 | EFNA3 | 0.753024 | 3 | 0 | 3 |
| MMP17 | ZNF524 | 0.736633 | 3 | 0 | 3 |
| MMP17 | PTPRN | 0.727229 | 3 | 0 | 3 |
| MMP17 | CDX2 | 0.719505 | 4 | 0 | 3 |
| MMP17 | GPHA2 | 0.718681 | 3 | 0 | 3 |
| MMP17 | SP6 | 0.718675 | 3 | 0 | 3 |
| MMP17 | CFC1 | 0.706127 | 3 | 0 | 3 |
| MMP17 | SLC48A1 | 0.703342 | 3 | 0 | 3 |
| MMP17 | LHFPL5 | 0.701529 | 3 | 0 | 3 |
| MMP17 | TBKBP1 | 0.698037 | 3 | 0 | 3 |
| MMP17 | LYPD4 | 0.696995 | 3 | 0 | 3 |
| MMP17 | KIF26B | 0.691462 | 3 | 0 | 3 |
| MMP17 | OXER1 | 0.68605 | 3 | 0 | 3 |
| MMP17 | IFT122 | 0.680612 | 3 | 0 | 3 |
| MMP17 | KRTAP4-8 | 0.679181 | 4 | 0 | 4 |
| MMP17 | ZNF646 | 0.676301 | 4 | 0 | 3 |
| MMP17 | IPO13 | 0.674012 | 4 | 0 | 3 |
| MMP17 | ISLR2 | 0.672317 | 4 | 0 | 3 |
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