| Full name: fizzy and cell division cycle 20 related 1 | Alias Symbol: HCDH1|CDH1|HCDH|FZR|FZR2|KIAA1242|CDC20C | ||
| Type: protein-coding gene | Cytoband: 19p13.3 | ||
| Entrez ID: 51343 | HGNC ID: HGNC:24824 | Ensembl Gene: ENSG00000105325 | OMIM ID: 603619 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
FZR1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04110 | Cell cycle | |
| hsa04914 | Progesterone-mediated oocyte maturation |
Expression of FZR1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FZR1 | 51343 | 209416_s_at | 0.3789 | 0.1463 | |
| GSE20347 | FZR1 | 51343 | 209415_at | 0.0138 | 0.8967 | |
| GSE23400 | FZR1 | 51343 | 209416_s_at | 0.1121 | 0.0436 | |
| GSE26886 | FZR1 | 51343 | 209415_at | -0.1256 | 0.2304 | |
| GSE29001 | FZR1 | 51343 | 209415_at | -0.0454 | 0.8539 | |
| GSE38129 | FZR1 | 51343 | 209415_at | -0.0513 | 0.4256 | |
| GSE45670 | FZR1 | 51343 | 209415_at | 0.1665 | 0.0467 | |
| GSE53622 | FZR1 | 51343 | 53737 | -0.0425 | 0.7414 | |
| GSE53624 | FZR1 | 51343 | 53737 | 0.5422 | 0.0000 | |
| GSE63941 | FZR1 | 51343 | 209415_at | 0.1057 | 0.5850 | |
| GSE77861 | FZR1 | 51343 | 209415_at | -0.0023 | 0.9903 | |
| GSE97050 | FZR1 | 51343 | A_33_P3268368 | 0.1056 | 0.7167 | |
| SRP007169 | FZR1 | 51343 | RNAseq | 0.7394 | 0.0661 | |
| SRP008496 | FZR1 | 51343 | RNAseq | 0.3672 | 0.1812 | |
| SRP064894 | FZR1 | 51343 | RNAseq | 0.3173 | 0.1455 | |
| SRP133303 | FZR1 | 51343 | RNAseq | 0.2380 | 0.1715 | |
| SRP159526 | FZR1 | 51343 | RNAseq | 0.3810 | 0.2220 | |
| SRP193095 | FZR1 | 51343 | RNAseq | 0.4475 | 0.0000 | |
| SRP219564 | FZR1 | 51343 | RNAseq | 0.5477 | 0.0474 | |
| TCGA | FZR1 | 51343 | RNAseq | 0.1717 | 0.0004 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by FZR1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FZR1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FZR1 | 51343 | 5 | 4 | 21 | |
| GSE20123 | FZR1 | 51343 | 4 | 3 | 23 | |
| GSE43470 | FZR1 | 51343 | 1 | 9 | 33 | |
| GSE46452 | FZR1 | 51343 | 47 | 1 | 11 | |
| GSE47630 | FZR1 | 51343 | 5 | 7 | 28 | |
| GSE54993 | FZR1 | 51343 | 16 | 3 | 51 | |
| GSE54994 | FZR1 | 51343 | 8 | 16 | 29 | |
| GSE60625 | FZR1 | 51343 | 9 | 0 | 2 | |
| GSE74703 | FZR1 | 51343 | 1 | 6 | 29 | |
| GSE74704 | FZR1 | 51343 | 1 | 3 | 16 | |
| TCGA | FZR1 | 51343 | 10 | 19 | 67 |
Total number of gains: 107; Total number of losses: 71; Total Number of normals: 310.
Somatic mutations of FZR1:
Generating mutation plots.
Highly correlated genes for FZR1:
Showing top 20/681 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FZR1 | KDM6B | 0.814486 | 3 | 0 | 3 |
| FZR1 | SMARCD1 | 0.813267 | 3 | 0 | 3 |
| FZR1 | KHSRP | 0.770311 | 3 | 0 | 3 |
| FZR1 | ZMIZ2 | 0.758387 | 3 | 0 | 3 |
| FZR1 | IGH | 0.757453 | 3 | 0 | 3 |
| FZR1 | GIT1 | 0.746583 | 6 | 0 | 5 |
| FZR1 | PELP1 | 0.742497 | 3 | 0 | 3 |
| FZR1 | CTBP2 | 0.741809 | 3 | 0 | 3 |
| FZR1 | GAL | 0.73889 | 3 | 0 | 3 |
| FZR1 | CRTC2 | 0.737607 | 4 | 0 | 4 |
| FZR1 | PDPR | 0.73407 | 3 | 0 | 3 |
| FZR1 | ARHGEF11 | 0.732429 | 4 | 0 | 3 |
| FZR1 | TBC1D25 | 0.731875 | 3 | 0 | 3 |
| FZR1 | ZNF358 | 0.725997 | 4 | 0 | 3 |
| FZR1 | ITGB3 | 0.725884 | 4 | 0 | 4 |
| FZR1 | U2AF2 | 0.725222 | 5 | 0 | 5 |
| FZR1 | VANGL2 | 0.724653 | 3 | 0 | 3 |
| FZR1 | ZNF628 | 0.722819 | 4 | 0 | 4 |
| FZR1 | PPP2R2D | 0.720851 | 3 | 0 | 3 |
| FZR1 | SCAF4 | 0.719233 | 4 | 0 | 4 |
For details and further investigation, click here
