| Full name: corticotropin releasing hormone receptor 1 | Alias Symbol: CRF-R|CRF1 | ||
| Type: protein-coding gene | Cytoband: 17q21.31 | ||
| Entrez ID: 1394 | HGNC ID: HGNC:2357 | Ensembl Gene: ENSG00000120088 | OMIM ID: 122561 |
| Drug and gene relationship at DGIdb | |||
Expression of CRHR1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CRHR1 | 1394 | 208593_x_at | 0.0017 | 0.9955 | |
| GSE20347 | CRHR1 | 1394 | 214619_at | -0.1025 | 0.2570 | |
| GSE23400 | CRHR1 | 1394 | 208593_x_at | -0.0381 | 0.2738 | |
| GSE26886 | CRHR1 | 1394 | 214619_at | 0.2710 | 0.0094 | |
| GSE29001 | CRHR1 | 1394 | 208593_x_at | -0.0783 | 0.5494 | |
| GSE38129 | CRHR1 | 1394 | 214619_at | -0.1012 | 0.2371 | |
| GSE45670 | CRHR1 | 1394 | 214619_at | -0.0915 | 0.4198 | |
| GSE53622 | CRHR1 | 1394 | 67000 | -0.5147 | 0.0000 | |
| GSE53624 | CRHR1 | 1394 | 67000 | -0.5998 | 0.0000 | |
| GSE63941 | CRHR1 | 1394 | 214619_at | 0.3179 | 0.0572 | |
| GSE77861 | CRHR1 | 1394 | 208593_x_at | -0.0764 | 0.4479 | |
| GSE97050 | CRHR1 | 1394 | A_33_P3320443 | -0.3509 | 0.1763 | |
| TCGA | CRHR1 | 1394 | RNAseq | 0.6399 | 0.5804 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CRHR1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CRHR1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CRHR1 | 1394 | 6 | 2 | 22 | |
| GSE20123 | CRHR1 | 1394 | 6 | 2 | 22 | |
| GSE43470 | CRHR1 | 1394 | 1 | 2 | 40 | |
| GSE46452 | CRHR1 | 1394 | 32 | 0 | 27 | |
| GSE47630 | CRHR1 | 1394 | 9 | 0 | 31 | |
| GSE54993 | CRHR1 | 1394 | 3 | 4 | 63 | |
| GSE54994 | CRHR1 | 1394 | 9 | 6 | 38 | |
| GSE60625 | CRHR1 | 1394 | 4 | 0 | 7 | |
| GSE74703 | CRHR1 | 1394 | 1 | 1 | 34 | |
| GSE74704 | CRHR1 | 1394 | 4 | 1 | 15 | |
| TCGA | CRHR1 | 1394 | 26 | 7 | 63 |
Total number of gains: 101; Total number of losses: 25; Total Number of normals: 362.
Somatic mutations of CRHR1:
Generating mutation plots.
Highly correlated genes for CRHR1:
Showing top 20/254 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CRHR1 | ZNF775 | 0.743287 | 3 | 0 | 3 |
| CRHR1 | FAM180B | 0.73272 | 3 | 0 | 3 |
| CRHR1 | TRAF3IP2-AS1 | 0.723589 | 3 | 0 | 3 |
| CRHR1 | MRVI1-AS1 | 0.713043 | 3 | 0 | 3 |
| CRHR1 | KRTAP6-3 | 0.710611 | 3 | 0 | 3 |
| CRHR1 | IGSF1 | 0.693092 | 4 | 0 | 3 |
| CRHR1 | OR7C2 | 0.6792 | 3 | 0 | 3 |
| CRHR1 | AQP5 | 0.675199 | 4 | 0 | 4 |
| CRHR1 | TRIM39 | 0.675009 | 3 | 0 | 3 |
| CRHR1 | PHF21B | 0.673865 | 4 | 0 | 3 |
| CRHR1 | DEFA6 | 0.672868 | 4 | 0 | 3 |
| CRHR1 | DPF3 | 0.661368 | 3 | 0 | 3 |
| CRHR1 | CNTN2 | 0.647541 | 3 | 0 | 3 |
| CRHR1 | IFNA16 | 0.647058 | 3 | 0 | 3 |
| CRHR1 | HABP2 | 0.643117 | 3 | 0 | 3 |
| CRHR1 | PHOX2B | 0.643105 | 3 | 0 | 3 |
| CRHR1 | SERPINA7 | 0.640573 | 4 | 0 | 3 |
| CRHR1 | IQSEC2 | 0.640516 | 8 | 0 | 7 |
| CRHR1 | LINC01361 | 0.633867 | 4 | 0 | 3 |
| CRHR1 | GPD1 | 0.632187 | 6 | 0 | 5 |
For details and further investigation, click here
