| Full name: aquaporin 5 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 12q13.12 | ||
| Entrez ID: 362 | HGNC ID: HGNC:638 | Ensembl Gene: ENSG00000161798 | OMIM ID: 600442 |
| Drug and gene relationship at DGIdb | |||
AQP5 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04970 | Salivary secretion |
Expression of AQP5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AQP5 | 362 | 213611_at | -0.7061 | 0.1298 | |
| GSE20347 | AQP5 | 362 | 213611_at | -0.1052 | 0.3902 | |
| GSE23400 | AQP5 | 362 | 213611_at | -0.1610 | 0.0000 | |
| GSE26886 | AQP5 | 362 | 213611_at | -0.0996 | 0.5490 | |
| GSE29001 | AQP5 | 362 | 213611_at | -0.2411 | 0.1716 | |
| GSE38129 | AQP5 | 362 | 213611_at | -0.2770 | 0.0073 | |
| GSE45670 | AQP5 | 362 | 213611_at | -0.5133 | 0.0212 | |
| GSE53622 | AQP5 | 362 | 106316 | -0.8521 | 0.0000 | |
| GSE53624 | AQP5 | 362 | 106316 | -1.1309 | 0.0000 | |
| GSE63941 | AQP5 | 362 | 213611_at | 0.0645 | 0.7695 | |
| GSE77861 | AQP5 | 362 | 213611_at | -0.1888 | 0.1777 | |
| GSE97050 | AQP5 | 362 | A_23_P366812 | -0.0219 | 0.9410 | |
| SRP064894 | AQP5 | 362 | RNAseq | -3.6041 | 0.0000 | |
| SRP133303 | AQP5 | 362 | RNAseq | -4.8741 | 0.0000 | |
| TCGA | AQP5 | 362 | RNAseq | -1.5736 | 0.0336 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by AQP5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AQP5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AQP5 | 362 | 8 | 1 | 21 | |
| GSE20123 | AQP5 | 362 | 8 | 1 | 21 | |
| GSE43470 | AQP5 | 362 | 3 | 0 | 40 | |
| GSE46452 | AQP5 | 362 | 8 | 1 | 50 | |
| GSE47630 | AQP5 | 362 | 11 | 2 | 27 | |
| GSE54993 | AQP5 | 362 | 0 | 5 | 65 | |
| GSE54994 | AQP5 | 362 | 4 | 1 | 48 | |
| GSE60625 | AQP5 | 362 | 0 | 0 | 11 | |
| GSE74703 | AQP5 | 362 | 3 | 0 | 33 | |
| GSE74704 | AQP5 | 362 | 5 | 1 | 14 | |
| TCGA | AQP5 | 362 | 15 | 11 | 70 |
Total number of gains: 65; Total number of losses: 23; Total Number of normals: 400.
Somatic mutations of AQP5:
Generating mutation plots.
Highly correlated genes for AQP5:
Showing top 20/362 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AQP5 | CLDN24 | 0.783936 | 3 | 0 | 3 |
| AQP5 | PTCH1 | 0.761018 | 3 | 0 | 3 |
| AQP5 | ENTPD8 | 0.739232 | 3 | 0 | 3 |
| AQP5 | SCARA5 | 0.704589 | 4 | 0 | 4 |
| AQP5 | SCGB3A1 | 0.689314 | 6 | 0 | 5 |
| AQP5 | VWCE | 0.687968 | 3 | 0 | 3 |
| AQP5 | FAAH2 | 0.686223 | 4 | 0 | 3 |
| AQP5 | SCGB2A1 | 0.682141 | 4 | 0 | 3 |
| AQP5 | SIGLEC8 | 0.679519 | 3 | 0 | 3 |
| AQP5 | VCX2 | 0.676728 | 3 | 0 | 3 |
| AQP5 | CRHR1 | 0.675199 | 4 | 0 | 4 |
| AQP5 | MFSD6L | 0.672103 | 4 | 0 | 4 |
| AQP5 | LRRC26 | 0.671035 | 3 | 0 | 3 |
| AQP5 | TFF1 | 0.669717 | 8 | 0 | 7 |
| AQP5 | C6orf58 | 0.667471 | 5 | 0 | 4 |
| AQP5 | OPRD1 | 0.66278 | 5 | 0 | 4 |
| AQP5 | TMEM125 | 0.662733 | 5 | 0 | 4 |
| AQP5 | LGALS9 | 0.661308 | 4 | 0 | 4 |
| AQP5 | KRTAP20-1 | 0.651177 | 3 | 0 | 3 |
| AQP5 | OR2Z1 | 0.648862 | 3 | 0 | 3 |
For details and further investigation, click here
