| Full name: defensin alpha 6 | Alias Symbol: HD-6|DEF6 | ||
| Type: protein-coding gene | Cytoband: 8p23.1 | ||
| Entrez ID: 1671 | HGNC ID: HGNC:2765 | Ensembl Gene: ENSG00000164822 | OMIM ID: 600471 |
| Drug and gene relationship at DGIdb | |||
Expression of DEFA6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DEFA6 | 1671 | 207814_at | 0.0373 | 0.8845 | |
| GSE20347 | DEFA6 | 1671 | 207814_at | 0.0883 | 0.4024 | |
| GSE23400 | DEFA6 | 1671 | 207814_at | -0.0788 | 0.0378 | |
| GSE26886 | DEFA6 | 1671 | 207814_at | 0.1779 | 0.0815 | |
| GSE29001 | DEFA6 | 1671 | 207814_at | -0.0787 | 0.7037 | |
| GSE38129 | DEFA6 | 1671 | 207814_at | -0.0699 | 0.5489 | |
| GSE45670 | DEFA6 | 1671 | 207814_at | 0.2214 | 0.0131 | |
| GSE53622 | DEFA6 | 1671 | 99270 | 0.0915 | 0.4472 | |
| GSE53624 | DEFA6 | 1671 | 99270 | 0.0853 | 0.4482 | |
| GSE63941 | DEFA6 | 1671 | 207814_at | 0.0532 | 0.7906 | |
| GSE77861 | DEFA6 | 1671 | 207814_at | -0.0659 | 0.4810 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DEFA6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DEFA6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DEFA6 | 1671 | 4 | 11 | 15 | |
| GSE20123 | DEFA6 | 1671 | 4 | 11 | 15 | |
| GSE43470 | DEFA6 | 1671 | 4 | 10 | 29 | |
| GSE46452 | DEFA6 | 1671 | 12 | 14 | 33 | |
| GSE47630 | DEFA6 | 1671 | 9 | 7 | 24 | |
| GSE54993 | DEFA6 | 1671 | 3 | 14 | 53 | |
| GSE54994 | DEFA6 | 1671 | 9 | 19 | 25 | |
| GSE60625 | DEFA6 | 1671 | 3 | 0 | 8 | |
| GSE74703 | DEFA6 | 1671 | 4 | 8 | 24 | |
| GSE74704 | DEFA6 | 1671 | 3 | 7 | 10 | |
| TCGA | DEFA6 | 1671 | 13 | 40 | 43 |
Total number of gains: 68; Total number of losses: 141; Total Number of normals: 279.
Somatic mutations of DEFA6:
Generating mutation plots.
Highly correlated genes for DEFA6:
Showing top 20/975 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DEFA6 | LIPF | 0.716138 | 3 | 0 | 3 |
| DEFA6 | LINC00311 | 0.712292 | 3 | 0 | 3 |
| DEFA6 | CCDC87 | 0.699069 | 5 | 0 | 5 |
| DEFA6 | ATG10 | 0.695557 | 4 | 0 | 4 |
| DEFA6 | C16orf70 | 0.690559 | 3 | 0 | 3 |
| DEFA6 | BEND4 | 0.690078 | 3 | 0 | 3 |
| DEFA6 | C1orf68 | 0.676804 | 5 | 0 | 4 |
| DEFA6 | ALDOB | 0.674582 | 5 | 0 | 5 |
| DEFA6 | CRHR1 | 0.672868 | 4 | 0 | 3 |
| DEFA6 | RUNX2 | 0.670473 | 4 | 0 | 4 |
| DEFA6 | NRP2 | 0.67015 | 3 | 0 | 3 |
| DEFA6 | GALNT8 | 0.668324 | 5 | 0 | 4 |
| DEFA6 | IFNA17 | 0.663622 | 4 | 0 | 4 |
| DEFA6 | RFPL2 | 0.662264 | 4 | 0 | 4 |
| DEFA6 | TRMT2B | 0.66029 | 3 | 0 | 3 |
| DEFA6 | LINC00408 | 0.657384 | 3 | 0 | 3 |
| DEFA6 | ASIC1 | 0.655111 | 5 | 0 | 5 |
| DEFA6 | KCNIP2 | 0.653224 | 5 | 0 | 4 |
| DEFA6 | C11orf16 | 0.652329 | 6 | 0 | 6 |
| DEFA6 | KCNMB2 | 0.651389 | 4 | 0 | 4 |
For details and further investigation, click here
