| Full name: paired like homeobox 2B | Alias Symbol: Phox2b|NBPhox | ||
| Type: protein-coding gene | Cytoband: 4p13 | ||
| Entrez ID: 8929 | HGNC ID: HGNC:9143 | Ensembl Gene: ENSG00000109132 | OMIM ID: 603851 |
| Drug and gene relationship at DGIdb | |||
Expression of PHOX2B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PHOX2B | 8929 | 207009_at | 0.0041 | 0.9936 | |
| GSE20347 | PHOX2B | 8929 | 207009_at | 0.1026 | 0.1874 | |
| GSE23400 | PHOX2B | 8929 | 207009_at | -0.0935 | 0.0066 | |
| GSE26886 | PHOX2B | 8929 | 207009_at | -0.0765 | 0.5007 | |
| GSE29001 | PHOX2B | 8929 | 207009_at | 0.0429 | 0.8333 | |
| GSE38129 | PHOX2B | 8929 | 207009_at | -0.0657 | 0.3892 | |
| GSE45670 | PHOX2B | 8929 | 207009_at | 0.2708 | 0.6738 | |
| GSE63941 | PHOX2B | 8929 | 207009_at | -0.0086 | 0.9627 | |
| GSE77861 | PHOX2B | 8929 | 207009_at | -0.1087 | 0.2081 | |
| TCGA | PHOX2B | 8929 | RNAseq | -3.5097 | 0.0021 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by PHOX2B expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of PHOX2B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PHOX2B | 8929 | 0 | 16 | 14 | |
| GSE20123 | PHOX2B | 8929 | 0 | 16 | 14 | |
| GSE43470 | PHOX2B | 8929 | 0 | 14 | 29 | |
| GSE46452 | PHOX2B | 8929 | 1 | 36 | 22 | |
| GSE47630 | PHOX2B | 8929 | 1 | 19 | 20 | |
| GSE54993 | PHOX2B | 8929 | 7 | 0 | 63 | |
| GSE54994 | PHOX2B | 8929 | 4 | 9 | 40 | |
| GSE60625 | PHOX2B | 8929 | 0 | 0 | 11 | |
| GSE74703 | PHOX2B | 8929 | 0 | 12 | 24 | |
| GSE74704 | PHOX2B | 8929 | 0 | 9 | 11 | |
| TCGA | PHOX2B | 8929 | 11 | 42 | 43 |
Total number of gains: 24; Total number of losses: 173; Total Number of normals: 291.
Somatic mutations of PHOX2B:
Generating mutation plots.
Highly correlated genes for PHOX2B:
Showing top 20/325 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PHOX2B | SIM1 | 0.702479 | 3 | 0 | 3 |
| PHOX2B | KIR3DL3 | 0.678955 | 4 | 0 | 4 |
| PHOX2B | SCG3 | 0.676736 | 3 | 0 | 3 |
| PHOX2B | ATG10 | 0.674539 | 4 | 0 | 4 |
| PHOX2B | SCGN | 0.673571 | 4 | 0 | 4 |
| PHOX2B | FAM66D | 0.66322 | 5 | 0 | 5 |
| PHOX2B | CCT8L2 | 0.657667 | 4 | 0 | 3 |
| PHOX2B | SLC45A2 | 0.654327 | 5 | 0 | 5 |
| PHOX2B | DEFA6 | 0.649826 | 5 | 0 | 5 |
| PHOX2B | MT3 | 0.647965 | 4 | 0 | 4 |
| PHOX2B | CHGA | 0.646933 | 4 | 0 | 3 |
| PHOX2B | CRHR1 | 0.643105 | 3 | 0 | 3 |
| PHOX2B | KIR2DL2 | 0.640474 | 4 | 0 | 4 |
| PHOX2B | HHIP | 0.639438 | 3 | 0 | 3 |
| PHOX2B | KIR2DL1 | 0.629723 | 4 | 0 | 4 |
| PHOX2B | CNTN2 | 0.627486 | 5 | 0 | 4 |
| PHOX2B | MC4R | 0.626356 | 6 | 0 | 4 |
| PHOX2B | MTAP | 0.622763 | 4 | 0 | 4 |
| PHOX2B | FOXI1 | 0.621894 | 3 | 0 | 3 |
| PHOX2B | CYP2D6 | 0.621746 | 4 | 0 | 4 |
For details and further investigation, click here
