| Full name: crystallin alpha A | Alias Symbol: HSPB4 | ||
| Type: protein-coding gene | Cytoband: 21q22.3 | ||
| Entrez ID: 1409 | HGNC ID: HGNC:2388 | Ensembl Gene: ENSG00000160202 | OMIM ID: 123580 |
| Drug and gene relationship at DGIdb | |||
Expression of CRYAA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CRYAA | 1409 | 210199_at | 0.0165 | 0.9646 | |
| GSE20347 | CRYAA | 1409 | 210199_at | -0.0083 | 0.9106 | |
| GSE23400 | CRYAA | 1409 | 210199_at | -0.1436 | 0.0000 | |
| GSE26886 | CRYAA | 1409 | 210199_at | 0.1270 | 0.3477 | |
| GSE29001 | CRYAA | 1409 | 210199_at | -0.2112 | 0.1246 | |
| GSE38129 | CRYAA | 1409 | 210199_at | -0.0623 | 0.3481 | |
| GSE45670 | CRYAA | 1409 | 210199_at | 0.0663 | 0.4911 | |
| GSE63941 | CRYAA | 1409 | 210199_at | 0.2179 | 0.2202 | |
| GSE77861 | CRYAA | 1409 | 210199_at | -0.0933 | 0.4974 | |
| GSE97050 | CRYAA | 1409 | A_33_P3323559 | 0.5835 | 0.1163 | |
| TCGA | CRYAA | 1409 | RNAseq | 1.7961 | 0.1239 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CRYAA expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of CRYAA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CRYAA | 1409 | 2 | 8 | 20 | |
| GSE20123 | CRYAA | 1409 | 2 | 8 | 20 | |
| GSE43470 | CRYAA | 1409 | 0 | 13 | 30 | |
| GSE46452 | CRYAA | 1409 | 1 | 21 | 37 | |
| GSE47630 | CRYAA | 1409 | 6 | 17 | 17 | |
| GSE54993 | CRYAA | 1409 | 8 | 1 | 61 | |
| GSE54994 | CRYAA | 1409 | 4 | 8 | 41 | |
| GSE60625 | CRYAA | 1409 | 0 | 0 | 11 | |
| GSE74703 | CRYAA | 1409 | 0 | 10 | 26 | |
| GSE74704 | CRYAA | 1409 | 1 | 4 | 15 | |
| TCGA | CRYAA | 1409 | 7 | 40 | 49 |
Total number of gains: 31; Total number of losses: 130; Total Number of normals: 327.
Somatic mutations of CRYAA:
Generating mutation plots.
Highly correlated genes for CRYAA:
Showing top 20/597 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CRYAA | SLC4A1 | 0.728282 | 4 | 0 | 4 |
| CRYAA | WFIKKN2 | 0.711281 | 3 | 0 | 3 |
| CRYAA | RGL4 | 0.710364 | 3 | 0 | 3 |
| CRYAA | PNMA6A | 0.710163 | 3 | 0 | 3 |
| CRYAA | ABCC2 | 0.708396 | 3 | 0 | 3 |
| CRYAA | ATXN7L2 | 0.706964 | 3 | 0 | 3 |
| CRYAA | TXNDC2 | 0.699737 | 4 | 0 | 4 |
| CRYAA | UBQLN3 | 0.699317 | 3 | 0 | 3 |
| CRYAA | CRYGN | 0.695457 | 3 | 0 | 3 |
| CRYAA | PTPRCAP | 0.692559 | 3 | 0 | 3 |
| CRYAA | CYP2W1 | 0.691401 | 3 | 0 | 3 |
| CRYAA | TSGA10 | 0.68769 | 3 | 0 | 3 |
| CRYAA | BCL6B | 0.687685 | 3 | 0 | 3 |
| CRYAA | SLC6A13 | 0.679669 | 5 | 0 | 5 |
| CRYAA | SRD5A2 | 0.67777 | 5 | 0 | 4 |
| CRYAA | BPIFB4 | 0.677585 | 4 | 0 | 3 |
| CRYAA | CDX2 | 0.672919 | 4 | 0 | 3 |
| CRYAA | CEBPE | 0.670454 | 4 | 0 | 4 |
| CRYAA | STK32C | 0.670447 | 3 | 0 | 3 |
| CRYAA | SPRED3 | 0.668426 | 3 | 0 | 3 |
For details and further investigation, click here
