| Full name: ATP binding cassette subfamily C member 2 | Alias Symbol: DJS|MRP2|cMRP | ||
| Type: protein-coding gene | Cytoband: 10q24.2 | ||
| Entrez ID: 1244 | HGNC ID: HGNC:53 | Ensembl Gene: ENSG00000023839 | OMIM ID: 601107 |
| Drug and gene relationship at DGIdb | |||
ABCC2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04976 | Bile secretion |
Expression of ABCC2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ABCC2 | 1244 | 206155_at | 0.1334 | 0.7501 | |
| GSE20347 | ABCC2 | 1244 | 206155_at | 0.0620 | 0.5226 | |
| GSE23400 | ABCC2 | 1244 | 206155_at | 0.0717 | 0.2057 | |
| GSE26886 | ABCC2 | 1244 | 206155_at | 0.1951 | 0.1513 | |
| GSE29001 | ABCC2 | 1244 | 206155_at | -0.0415 | 0.7524 | |
| GSE38129 | ABCC2 | 1244 | 206155_at | -0.0069 | 0.9516 | |
| GSE45670 | ABCC2 | 1244 | 206155_at | 0.2390 | 0.2657 | |
| GSE53622 | ABCC2 | 1244 | 69951 | 0.2997 | 0.0770 | |
| GSE53624 | ABCC2 | 1244 | 69951 | 0.8681 | 0.0000 | |
| GSE63941 | ABCC2 | 1244 | 206155_at | 0.6498 | 0.5896 | |
| GSE77861 | ABCC2 | 1244 | 206155_at | 0.1119 | 0.3816 | |
| GSE97050 | ABCC2 | 1244 | A_23_P44569 | 0.4963 | 0.1367 | |
| SRP133303 | ABCC2 | 1244 | RNAseq | 0.6036 | 0.0985 | |
| SRP193095 | ABCC2 | 1244 | RNAseq | 0.6692 | 0.2815 | |
| SRP219564 | ABCC2 | 1244 | RNAseq | 0.7427 | 0.1385 | |
| TCGA | ABCC2 | 1244 | RNAseq | 0.4990 | 0.1593 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ABCC2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ABCC2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ABCC2 | 1244 | 1 | 8 | 21 | |
| GSE20123 | ABCC2 | 1244 | 1 | 7 | 22 | |
| GSE43470 | ABCC2 | 1244 | 0 | 7 | 36 | |
| GSE46452 | ABCC2 | 1244 | 0 | 11 | 48 | |
| GSE47630 | ABCC2 | 1244 | 2 | 14 | 24 | |
| GSE54993 | ABCC2 | 1244 | 8 | 0 | 62 | |
| GSE54994 | ABCC2 | 1244 | 1 | 12 | 40 | |
| GSE60625 | ABCC2 | 1244 | 0 | 0 | 11 | |
| GSE74703 | ABCC2 | 1244 | 0 | 5 | 31 | |
| GSE74704 | ABCC2 | 1244 | 0 | 4 | 16 | |
| TCGA | ABCC2 | 1244 | 5 | 28 | 63 |
Total number of gains: 18; Total number of losses: 96; Total Number of normals: 374.
Somatic mutations of ABCC2:
Generating mutation plots.
Highly correlated genes for ABCC2:
Showing top 20/264 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ABCC2 | GPR32 | 0.794993 | 3 | 0 | 3 |
| ABCC2 | GPR35 | 0.768317 | 3 | 0 | 3 |
| ABCC2 | FGF18 | 0.751191 | 3 | 0 | 3 |
| ABCC2 | SLC5A4 | 0.747353 | 4 | 0 | 4 |
| ABCC2 | TP73 | 0.743327 | 3 | 0 | 3 |
| ABCC2 | NKAIN4 | 0.738898 | 3 | 0 | 3 |
| ABCC2 | PTPRN2 | 0.725043 | 3 | 0 | 3 |
| ABCC2 | PMEPA1 | 0.722741 | 3 | 0 | 3 |
| ABCC2 | TLR9 | 0.720694 | 4 | 0 | 4 |
| ABCC2 | B3GALT1 | 0.716834 | 3 | 0 | 3 |
| ABCC2 | FFAR1 | 0.713268 | 3 | 0 | 3 |
| ABCC2 | CRYAA | 0.708396 | 3 | 0 | 3 |
| ABCC2 | CLEC4M | 0.704441 | 3 | 0 | 3 |
| ABCC2 | TRIM17 | 0.700117 | 3 | 0 | 3 |
| ABCC2 | PRG3 | 0.694994 | 3 | 0 | 3 |
| ABCC2 | ATP2B3 | 0.690817 | 3 | 0 | 3 |
| ABCC2 | CELA3B | 0.689986 | 3 | 0 | 3 |
| ABCC2 | ASIC4 | 0.689531 | 3 | 0 | 3 |
| ABCC2 | APLN | 0.686619 | 3 | 0 | 3 |
| ABCC2 | ZFPM1 | 0.686168 | 3 | 0 | 3 |
For details and further investigation, click here
