| Full name: steroid 5 alpha-reductase 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2p23.1 | ||
| Entrez ID: 6716 | HGNC ID: HGNC:11285 | Ensembl Gene: ENSG00000277893 | OMIM ID: 607306 |
| Drug and gene relationship at DGIdb | |||
Expression of SRD5A2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SRD5A2 | 6716 | 206938_at | -0.1152 | 0.6249 | |
| GSE20347 | SRD5A2 | 6716 | 206938_at | 0.0318 | 0.7114 | |
| GSE23400 | SRD5A2 | 6716 | 206938_at | -0.1285 | 0.0003 | |
| GSE26886 | SRD5A2 | 6716 | 206938_at | 0.0735 | 0.5892 | |
| GSE29001 | SRD5A2 | 6716 | 206938_at | -0.2390 | 0.0581 | |
| GSE38129 | SRD5A2 | 6716 | 206938_at | -0.0753 | 0.3689 | |
| GSE45670 | SRD5A2 | 6716 | 206938_at | -0.1146 | 0.1670 | |
| GSE53622 | SRD5A2 | 6716 | 89987 | 0.1205 | 0.0492 | |
| GSE53624 | SRD5A2 | 6716 | 89987 | 0.0087 | 0.9169 | |
| GSE63941 | SRD5A2 | 6716 | 206938_at | 0.1147 | 0.3800 | |
| GSE77861 | SRD5A2 | 6716 | 206938_at | -0.0623 | 0.5605 | |
| GSE97050 | SRD5A2 | 6716 | A_23_P28186 | 0.0266 | 0.9024 | |
| TCGA | SRD5A2 | 6716 | RNAseq | 0.4850 | 0.5764 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SRD5A2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SRD5A2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SRD5A2 | 6716 | 10 | 1 | 19 | |
| GSE20123 | SRD5A2 | 6716 | 9 | 1 | 20 | |
| GSE43470 | SRD5A2 | 6716 | 2 | 1 | 40 | |
| GSE46452 | SRD5A2 | 6716 | 2 | 4 | 53 | |
| GSE47630 | SRD5A2 | 6716 | 8 | 0 | 32 | |
| GSE54993 | SRD5A2 | 6716 | 0 | 5 | 65 | |
| GSE54994 | SRD5A2 | 6716 | 10 | 0 | 43 | |
| GSE60625 | SRD5A2 | 6716 | 0 | 3 | 8 | |
| GSE74703 | SRD5A2 | 6716 | 2 | 0 | 34 | |
| GSE74704 | SRD5A2 | 6716 | 9 | 1 | 10 | |
| TCGA | SRD5A2 | 6716 | 36 | 2 | 58 |
Total number of gains: 88; Total number of losses: 18; Total Number of normals: 382.
Somatic mutations of SRD5A2:
Generating mutation plots.
Highly correlated genes for SRD5A2:
Showing top 20/886 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SRD5A2 | ABCA4 | 0.772769 | 3 | 0 | 3 |
| SRD5A2 | OR10W1 | 0.7599 | 3 | 0 | 3 |
| SRD5A2 | CABP7 | 0.740712 | 4 | 0 | 4 |
| SRD5A2 | OR2B11 | 0.739395 | 3 | 0 | 3 |
| SRD5A2 | ZAN | 0.731273 | 3 | 0 | 3 |
| SRD5A2 | CRYGA | 0.725362 | 4 | 0 | 3 |
| SRD5A2 | OR7G2 | 0.719253 | 3 | 0 | 3 |
| SRD5A2 | INSC | 0.715614 | 3 | 0 | 3 |
| SRD5A2 | OR2D2 | 0.71234 | 3 | 0 | 3 |
| SRD5A2 | SLC10A1 | 0.709708 | 6 | 0 | 6 |
| SRD5A2 | AICDA | 0.703645 | 3 | 0 | 3 |
| SRD5A2 | LY6H | 0.702704 | 4 | 0 | 4 |
| SRD5A2 | OR10C1 | 0.701769 | 5 | 0 | 5 |
| SRD5A2 | FOLH1 | 0.701065 | 5 | 0 | 5 |
| SRD5A2 | OR2T1 | 0.697872 | 3 | 0 | 3 |
| SRD5A2 | CPN1 | 0.696899 | 5 | 0 | 5 |
| SRD5A2 | SPACA5 | 0.695291 | 3 | 0 | 3 |
| SRD5A2 | THPO | 0.693245 | 4 | 0 | 3 |
| SRD5A2 | TSGA10 | 0.692566 | 3 | 0 | 3 |
| SRD5A2 | C16orf71 | 0.69183 | 4 | 0 | 4 |
For details and further investigation, click here
