| Full name: cathepsin W | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 11q13.1 | ||
| Entrez ID: 1521 | HGNC ID: HGNC:2546 | Ensembl Gene: ENSG00000172543 | OMIM ID: 602364 |
| Drug and gene relationship at DGIdb | |||
CTSW involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04210 | Apoptosis |
Expression of CTSW:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CTSW | 1521 | 214450_at | -0.1415 | 0.6959 | |
| GSE20347 | CTSW | 1521 | 214450_at | -0.1345 | 0.0446 | |
| GSE23400 | CTSW | 1521 | 214450_at | -0.1815 | 0.0020 | |
| GSE26886 | CTSW | 1521 | 214450_at | 0.0395 | 0.8284 | |
| GSE29001 | CTSW | 1521 | 214450_at | -0.1828 | 0.2128 | |
| GSE38129 | CTSW | 1521 | 214450_at | -0.2514 | 0.0067 | |
| GSE45670 | CTSW | 1521 | 214450_at | 0.0563 | 0.6134 | |
| GSE53622 | CTSW | 1521 | 42594 | -0.3304 | 0.2270 | |
| GSE53624 | CTSW | 1521 | 42594 | -0.1502 | 0.5004 | |
| GSE63941 | CTSW | 1521 | 214450_at | 0.4862 | 0.0007 | |
| GSE77861 | CTSW | 1521 | 214450_at | -0.0356 | 0.8094 | |
| GSE97050 | CTSW | 1521 | A_24_P396167 | 0.5781 | 0.2379 | |
| SRP064894 | CTSW | 1521 | RNAseq | -0.3501 | 0.4150 | |
| SRP133303 | CTSW | 1521 | RNAseq | -0.5061 | 0.2877 | |
| SRP159526 | CTSW | 1521 | RNAseq | -0.9209 | 0.2587 | |
| SRP193095 | CTSW | 1521 | RNAseq | -0.2051 | 0.4355 | |
| SRP219564 | CTSW | 1521 | RNAseq | 1.4342 | 0.0007 | |
| TCGA | CTSW | 1521 | RNAseq | 0.1165 | 0.7110 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by CTSW expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CTSW:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CTSW | 1521 | 8 | 5 | 17 | |
| GSE20123 | CTSW | 1521 | 8 | 5 | 17 | |
| GSE43470 | CTSW | 1521 | 6 | 1 | 36 | |
| GSE46452 | CTSW | 1521 | 11 | 3 | 45 | |
| GSE47630 | CTSW | 1521 | 7 | 5 | 28 | |
| GSE54993 | CTSW | 1521 | 3 | 0 | 67 | |
| GSE54994 | CTSW | 1521 | 7 | 5 | 41 | |
| GSE60625 | CTSW | 1521 | 0 | 3 | 8 | |
| GSE74703 | CTSW | 1521 | 4 | 0 | 32 | |
| GSE74704 | CTSW | 1521 | 6 | 3 | 11 | |
| TCGA | CTSW | 1521 | 23 | 7 | 66 |
Total number of gains: 83; Total number of losses: 37; Total Number of normals: 368.
Somatic mutations of CTSW:
Generating mutation plots.
Highly correlated genes for CTSW:
Showing top 20/364 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CTSW | SCRG1 | 0.737929 | 3 | 0 | 3 |
| CTSW | LDOC1 | 0.699264 | 3 | 0 | 3 |
| CTSW | AMOT | 0.677258 | 4 | 0 | 4 |
| CTSW | ARX | 0.657146 | 3 | 0 | 3 |
| CTSW | RAB3IL1 | 0.643912 | 4 | 0 | 3 |
| CTSW | MICALCL | 0.631917 | 3 | 0 | 3 |
| CTSW | DLGAP2 | 0.629257 | 5 | 0 | 4 |
| CTSW | RBP5 | 0.629118 | 4 | 0 | 4 |
| CTSW | ZFPL1 | 0.628721 | 4 | 0 | 4 |
| CTSW | RPS15 | 0.62677 | 4 | 0 | 4 |
| CTSW | SLC6A5 | 0.626756 | 4 | 0 | 4 |
| CTSW | PIK3R5 | 0.625009 | 7 | 0 | 7 |
| CTSW | GALNT8 | 0.624737 | 3 | 0 | 3 |
| CTSW | FBXL19 | 0.623517 | 3 | 0 | 3 |
| CTSW | CDX1 | 0.621891 | 6 | 0 | 6 |
| CTSW | LEMD1-AS1 | 0.620933 | 4 | 0 | 3 |
| CTSW | SNX20 | 0.617156 | 3 | 0 | 3 |
| CTSW | LMF2 | 0.616547 | 3 | 0 | 3 |
| CTSW | IL1RAPL1 | 0.613333 | 3 | 0 | 3 |
| CTSW | GZMA | 0.612954 | 5 | 0 | 4 |
For details and further investigation, click here
