| Full name: solute carrier family 6 member 5 | Alias Symbol: GLYT2 | ||
| Type: protein-coding gene | Cytoband: 11p15.1 | ||
| Entrez ID: 9152 | HGNC ID: HGNC:11051 | Ensembl Gene: ENSG00000165970 | OMIM ID: 604159 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SLC6A5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SLC6A5 | 9152 | 210810_s_at | -0.0580 | 0.8277 | |
| GSE20347 | SLC6A5 | 9152 | 210810_s_at | 0.0287 | 0.7367 | |
| GSE23400 | SLC6A5 | 9152 | 210810_s_at | -0.2284 | 0.0000 | |
| GSE26886 | SLC6A5 | 9152 | 236508_at | 0.1086 | 0.2516 | |
| GSE29001 | SLC6A5 | 9152 | 210810_s_at | -0.1151 | 0.5308 | |
| GSE38129 | SLC6A5 | 9152 | 210810_s_at | -0.1226 | 0.1462 | |
| GSE45670 | SLC6A5 | 9152 | 210810_s_at | 0.0422 | 0.5722 | |
| GSE53622 | SLC6A5 | 9152 | 20152 | 0.1574 | 0.1221 | |
| GSE53624 | SLC6A5 | 9152 | 20152 | 0.1005 | 0.2668 | |
| GSE63941 | SLC6A5 | 9152 | 210810_s_at | 0.0634 | 0.7241 | |
| GSE77861 | SLC6A5 | 9152 | 236508_at | 0.0366 | 0.8059 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SLC6A5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SLC6A5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SLC6A5 | 9152 | 0 | 9 | 21 | |
| GSE20123 | SLC6A5 | 9152 | 0 | 10 | 20 | |
| GSE43470 | SLC6A5 | 9152 | 1 | 5 | 37 | |
| GSE46452 | SLC6A5 | 9152 | 7 | 5 | 47 | |
| GSE47630 | SLC6A5 | 9152 | 3 | 10 | 27 | |
| GSE54993 | SLC6A5 | 9152 | 3 | 0 | 67 | |
| GSE54994 | SLC6A5 | 9152 | 3 | 12 | 38 | |
| GSE60625 | SLC6A5 | 9152 | 0 | 0 | 11 | |
| GSE74703 | SLC6A5 | 9152 | 1 | 3 | 32 | |
| GSE74704 | SLC6A5 | 9152 | 0 | 8 | 12 | |
| TCGA | SLC6A5 | 9152 | 12 | 26 | 58 |
Total number of gains: 30; Total number of losses: 88; Total Number of normals: 370.
Somatic mutations of SLC6A5:
Generating mutation plots.
Highly correlated genes for SLC6A5:
Showing top 20/838 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SLC6A5 | LGALS14 | 0.783016 | 3 | 0 | 3 |
| SLC6A5 | SSTR4 | 0.769171 | 3 | 0 | 3 |
| SLC6A5 | TNFSF8 | 0.767766 | 3 | 0 | 3 |
| SLC6A5 | AMELY | 0.754335 | 3 | 0 | 3 |
| SLC6A5 | DRD5 | 0.747768 | 4 | 0 | 4 |
| SLC6A5 | SLC2A2 | 0.745789 | 3 | 0 | 3 |
| SLC6A5 | EPHA5 | 0.739626 | 5 | 0 | 5 |
| SLC6A5 | GPLD1 | 0.738919 | 3 | 0 | 3 |
| SLC6A5 | IL1RAPL2 | 0.736774 | 4 | 0 | 4 |
| SLC6A5 | CAMKV | 0.734266 | 4 | 0 | 4 |
| SLC6A5 | HLA-DOA | 0.733325 | 4 | 0 | 4 |
| SLC6A5 | APOA1 | 0.729104 | 3 | 0 | 3 |
| SLC6A5 | FOXN3-AS2 | 0.728387 | 4 | 0 | 4 |
| SLC6A5 | KRT38 | 0.720296 | 3 | 0 | 3 |
| SLC6A5 | LINC00474 | 0.719485 | 4 | 0 | 4 |
| SLC6A5 | MYBPH | 0.718101 | 3 | 0 | 3 |
| SLC6A5 | OTOR | 0.717799 | 3 | 0 | 3 |
| SLC6A5 | APCS | 0.717249 | 4 | 0 | 4 |
| SLC6A5 | CALCB | 0.716959 | 3 | 0 | 3 |
| SLC6A5 | PHLDB1 | 0.716938 | 4 | 0 | 3 |
For details and further investigation, click here
