Full name: phosphoinositide-3-kinase regulatory subunit 5	Alias Symbol: P101-PI3K|p101
Type: protein-coding gene	Cytoband: 17p13.1
Entrez ID: 23533	HGNC ID: HGNC:30035	Ensembl Gene: ENSG00000141506	OMIM ID: 611317
Drug and gene relationship at DGIdb
Screen Evidence: Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

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PIK3R5 involved pathways:

KEGG pathway	Description	View
hsa04012	ErbB signaling pathway	View
hsa04014	Ras signaling pathway	View
hsa04015	Rap1 signaling pathway	View
hsa04022	cGMP-PKG signaling pathway	View
hsa04024	cAMP signaling pathway	View
hsa04062	Chemokine signaling pathway	View
hsa04066	HIF-1 signaling pathway	View
hsa04068	FoxO signaling pathway	View
hsa04071	Sphingolipid signaling pathway	View
hsa04072	Phospholipase D signaling pathway	View
hsa04150	mTOR signaling pathway	View
hsa04151	PI3K-Akt signaling pathway	View
hsa04152	AMPK signaling pathway	View
hsa04210	Apoptosis	View
hsa04211	Longevity regulating pathway - mammal	View
hsa04213	Longevity regulating pathway - multiple species	View
hsa04261	Adrenergic signaling in cardiomyocytes	View
hsa04360	Axon guidance	View
hsa04370	VEGF signaling pathway	View
hsa04380	Osteoclast differentiation	View
hsa04510	Focal adhesion	View
hsa04550	Signaling pathways regulating pluripotency of stem cells	View
hsa04611	Platelet activation	View
hsa04620	Toll-like receptor signaling pathway	View
hsa04630	Jak-STAT signaling pathway	View
hsa04650	Natural killer cell mediated cytotoxicity	View
hsa04660	T cell receptor signaling pathway	View
hsa04662	B cell receptor signaling pathway	View
hsa04664	Fc epsilon RI signaling pathway	View
hsa04666	Fc gamma R-mediated phagocytosis	View
hsa04668	TNF signaling pathway	View
hsa04670	Leukocyte transendothelial migration	View
hsa04722	Neurotrophin signaling pathway	View
hsa04725	Cholinergic synapse	View
hsa04750	Inflammatory mediator regulation of TRP channels	View
hsa04810	Regulation of actin cytoskeleton	View
hsa04910	Insulin signaling pathway	View
hsa04914	Progesterone-mediated oocyte maturation	View
hsa04915	Estrogen signaling pathway	View
hsa04917	Prolactin signaling pathway	View
hsa04919	Thyroid hormone signaling pathway	View
hsa04921	Oxytocin signaling pathway	View
hsa04923	Regulation of lipolysis in adipocytes	View
hsa04930	Type II diabetes mellitus	View
hsa04931	Insulin resistance	View
hsa04932	Non-alcoholic fatty liver disease (NAFLD)	View
hsa04933	AGE-RAGE signaling pathway in diabetic complications	View
hsa04960	Aldosterone-regulated sodium reabsorption	View
hsa04973	Carbohydrate digestion and absorption	View
hsa05100	Bacterial invasion of epithelial cells	View
hsa05142	Chagas disease (American trypanosomiasis)	View
hsa05145	Toxoplasmosis	View
hsa05160	Hepatitis C	View
hsa05161	Hepatitis B	View
hsa05162	Measles	View
hsa05164	Influenza A	View
hsa05166	HTLV-I infection	View
hsa05169	Epstein-Barr virus infection	View
hsa05200	Pathways in cancer	View
hsa05205	Proteoglycans in cancer	View
hsa05210	Colorectal cancer	View
hsa05211	Renal cell carcinoma	View
hsa05212	Pancreatic cancer	View
hsa05213	Endometrial cancer	View
hsa05214	Glioma	View
hsa05215	Prostate cancer	View
hsa05218	Melanoma	View
hsa05220	Chronic myeloid leukemia	View
hsa05221	Acute myeloid leukemia	View
hsa05222	Small cell lung cancer	View
hsa05223	Non-small cell lung cancer	View
hsa05231	Choline metabolism in cancer	View

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Expression of PIK3R5:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	PIK3R5	23533	227645_at	0.1767	0.8641	Show
GSE20347	PIK3R5	23533	220566_at	-0.1523	0.0803	Show
GSE23400	PIK3R5	23533	220566_at	-0.2173	0.0000	Show
GSE26886	PIK3R5	23533	220566_at	-0.0479	0.6509	Show
GSE29001	PIK3R5	23533	220566_at	-0.3148	0.0251	Show
GSE38129	PIK3R5	23533	220566_at	-0.1410	0.0563	Show
GSE45670	PIK3R5	23533	227645_at	-0.1383	0.5121	Show
GSE53622	PIK3R5	23533	78671	0.1200	0.3725	Show
GSE53624	PIK3R5	23533	78671	0.2050	0.0173	Show
GSE63941	PIK3R5	23533	220566_at	0.0823	0.4837	Show
GSE77861	PIK3R5	23533	220566_at	-0.1428	0.3033	Show
GSE97050	PIK3R5	23533	A_23_P66543	0.3609	0.2841	Show
SRP007169	PIK3R5	23533	RNAseq	0.7147	0.3782	Show
SRP064894	PIK3R5	23533	RNAseq	0.3956	0.1658	Show
SRP133303	PIK3R5	23533	RNAseq	0.3149	0.1831	Show
SRP159526	PIK3R5	23533	RNAseq	-0.5748	0.4381	Show
SRP193095	PIK3R5	23533	RNAseq	0.6240	0.0027	Show
SRP219564	PIK3R5	23533	RNAseq	0.9582	0.0403	Show
TCGA	PIK3R5	23533	RNAseq	-0.1501	0.3600	Show

Upregulated datasets: 0; Downregulated datasets: 0.  Download Data

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Survival by PIK3R5 expression:

 

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Copy number change of PIK3R5:

 

Dataset	Gene	EntrezID	Gain	Loss	Normal	Detail
GSE15526	PIK3R5	23533	3	3	24	Show
GSE20123	PIK3R5	23533	3	4	23	Show
GSE43470	PIK3R5	23533	1	6	36	Show
GSE46452	PIK3R5	23533	34	1	24	Show
GSE47630	PIK3R5	23533	7	1	32	Show
GSE54993	PIK3R5	23533	4	3	63	Show
GSE54994	PIK3R5	23533	5	8	40	Show
GSE60625	PIK3R5	23533	4	0	7	Show
GSE74703	PIK3R5	23533	1	3	32	Show
GSE74704	PIK3R5	23533	1	2	17	Show
TCGA	PIK3R5	23533	17	20	59	Show

Total number of gains: 80; Total number of losses: 51; Total Number of normals: 357.  Download Data

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Somatic mutations of PIK3R5:

 

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Highly correlated genes for PIK3R5:

 

Showing top 20/838 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
PIK3R5	CD53	0.869642	3	0	3
PIK3R5	LCP2	0.836706	5	0	5
PIK3R5	PREX1	0.816187	3	0	3
PIK3R5	PTPRC	0.804892	4	0	4
PIK3R5	PLEK	0.787691	4	0	4
PIK3R5	EVI2B	0.785587	5	0	5
PIK3R5	GPR65	0.766766	5	0	4
PIK3R5	CORO1A	0.764738	5	0	5
PIK3R5	C19orf38	0.763105	3	0	3
PIK3R5	LRRC25	0.754256	4	0	4
PIK3R5	CD37	0.751815	5	0	5
PIK3R5	PTPN7	0.750497	5	0	5
PIK3R5	IRF8	0.750326	5	0	5
PIK3R5	CCR1	0.745054	5	0	5
PIK3R5	MPEG1	0.740379	5	0	5
PIK3R5	SMAP2	0.739566	5	0	5
PIK3R5	ARHGDIB	0.737981	5	0	5
PIK3R5	DOCK2	0.737949	5	0	5
PIK3R5	PHLDB1	0.735541	6	0	5
PIK3R5	TFEC	0.733067	5	0	5

For details and further investigation, click here