| Full name: granzyme A | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 5q11.2 | ||
| Entrez ID: 3001 | HGNC ID: HGNC:4708 | Ensembl Gene: ENSG00000145649 | OMIM ID: 140050 |
| Drug and gene relationship at DGIdb | |||
Expression of GZMA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GZMA | 3001 | 205488_at | 0.7088 | 0.6116 | |
| GSE20347 | GZMA | 3001 | 205488_at | -0.0629 | 0.8757 | |
| GSE23400 | GZMA | 3001 | 205488_at | 0.3924 | 0.0018 | |
| GSE26886 | GZMA | 3001 | 205488_at | 0.3483 | 0.6744 | |
| GSE29001 | GZMA | 3001 | 205488_at | 0.6064 | 0.1382 | |
| GSE38129 | GZMA | 3001 | 205488_at | -0.0713 | 0.8287 | |
| GSE45670 | GZMA | 3001 | 205488_at | 0.1757 | 0.7904 | |
| GSE53622 | GZMA | 3001 | 58229 | 0.2623 | 0.2841 | |
| GSE53624 | GZMA | 3001 | 58229 | 0.2107 | 0.2782 | |
| GSE63941 | GZMA | 3001 | 205488_at | -0.0441 | 0.7857 | |
| GSE77861 | GZMA | 3001 | 205488_at | -0.1519 | 0.5501 | |
| GSE97050 | GZMA | 3001 | A_33_P3376821 | 0.8325 | 0.1998 | |
| SRP007169 | GZMA | 3001 | RNAseq | 0.6336 | 0.3619 | |
| SRP064894 | GZMA | 3001 | RNAseq | 0.0412 | 0.9128 | |
| SRP133303 | GZMA | 3001 | RNAseq | 0.6481 | 0.1713 | |
| SRP159526 | GZMA | 3001 | RNAseq | -0.2512 | 0.8049 | |
| SRP193095 | GZMA | 3001 | RNAseq | -0.2930 | 0.3209 | |
| SRP219564 | GZMA | 3001 | RNAseq | 1.1788 | 0.0576 | |
| TCGA | GZMA | 3001 | RNAseq | 0.9186 | 0.0043 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by GZMA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GZMA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GZMA | 3001 | 1 | 13 | 16 | |
| GSE20123 | GZMA | 3001 | 1 | 13 | 16 | |
| GSE43470 | GZMA | 3001 | 1 | 12 | 30 | |
| GSE46452 | GZMA | 3001 | 1 | 27 | 31 | |
| GSE47630 | GZMA | 3001 | 2 | 16 | 22 | |
| GSE54993 | GZMA | 3001 | 8 | 1 | 61 | |
| GSE54994 | GZMA | 3001 | 4 | 19 | 30 | |
| GSE60625 | GZMA | 3001 | 0 | 0 | 11 | |
| GSE74703 | GZMA | 3001 | 1 | 9 | 26 | |
| GSE74704 | GZMA | 3001 | 1 | 6 | 13 | |
| TCGA | GZMA | 3001 | 8 | 45 | 43 |
Total number of gains: 28; Total number of losses: 161; Total Number of normals: 299.
Somatic mutations of GZMA:
Generating mutation plots.
Highly correlated genes for GZMA:
Showing top 20/363 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GZMA | BCL2L11 | 0.854195 | 3 | 0 | 3 |
| GZMA | GPR174 | 0.77902 | 3 | 0 | 3 |
| GZMA | NKG7 | 0.763021 | 11 | 0 | 10 |
| GZMA | PRF1 | 0.747609 | 11 | 0 | 10 |
| GZMA | PTPN22 | 0.747315 | 5 | 0 | 5 |
| GZMA | IL2RG | 0.746365 | 7 | 0 | 6 |
| GZMA | GZMB | 0.745779 | 11 | 0 | 11 |
| GZMA | IL2RB | 0.738345 | 12 | 0 | 11 |
| GZMA | PSMB8-AS1 | 0.728213 | 5 | 0 | 5 |
| GZMA | GNGT2 | 0.72795 | 4 | 0 | 4 |
| GZMA | ACAP1 | 0.722631 | 5 | 0 | 5 |
| GZMA | SAMD3 | 0.714436 | 5 | 0 | 5 |
| GZMA | GNLY | 0.710743 | 10 | 0 | 9 |
| GZMA | PIK3R5 | 0.70763 | 4 | 0 | 3 |
| GZMA | CCL5 | 0.706427 | 12 | 0 | 11 |
| GZMA | SUSD3 | 0.70148 | 5 | 0 | 4 |
| GZMA | CD37 | 0.694317 | 6 | 0 | 6 |
| GZMA | CD8A | 0.693947 | 9 | 0 | 8 |
| GZMA | LCK | 0.692097 | 11 | 0 | 11 |
| GZMA | HAVCR2 | 0.684103 | 4 | 0 | 4 |
For details and further investigation, click here
