| Full name: F-box and leucine rich repeat protein 19 | Alias Symbol: DKFZp434K0410|Fbl19|JHDM1C|CXXC11 | ||
| Type: protein-coding gene | Cytoband: 16p11.2 | ||
| Entrez ID: 54620 | HGNC ID: HGNC:25300 | Ensembl Gene: ENSG00000099364 | OMIM ID: 609085 |
| Drug and gene relationship at DGIdb | |||
Expression of FBXL19:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FBXL19 | 54620 | 228277_at | 0.3598 | 0.3532 | |
| GSE26886 | FBXL19 | 54620 | 228277_at | 0.2347 | 0.1155 | |
| GSE45670 | FBXL19 | 54620 | 228277_at | 0.3179 | 0.0053 | |
| GSE53622 | FBXL19 | 54620 | 32168 | 0.3717 | 0.0000 | |
| GSE53624 | FBXL19 | 54620 | 17159 | 0.3208 | 0.0000 | |
| GSE63941 | FBXL19 | 54620 | 228277_at | 0.9344 | 0.0173 | |
| GSE77861 | FBXL19 | 54620 | 228277_at | 0.0436 | 0.8745 | |
| GSE97050 | FBXL19 | 54620 | A_23_P338168 | 0.2071 | 0.3162 | |
| SRP007169 | FBXL19 | 54620 | RNAseq | -0.5372 | 0.1472 | |
| SRP008496 | FBXL19 | 54620 | RNAseq | -0.4335 | 0.1277 | |
| SRP064894 | FBXL19 | 54620 | RNAseq | 0.4233 | 0.0503 | |
| SRP133303 | FBXL19 | 54620 | RNAseq | 0.3407 | 0.1982 | |
| SRP159526 | FBXL19 | 54620 | RNAseq | 0.2480 | 0.3323 | |
| SRP193095 | FBXL19 | 54620 | RNAseq | 0.2984 | 0.0295 | |
| SRP219564 | FBXL19 | 54620 | RNAseq | 0.0453 | 0.8876 | |
| TCGA | FBXL19 | 54620 | RNAseq | 0.2667 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by FBXL19 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FBXL19:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FBXL19 | 54620 | 5 | 5 | 20 | |
| GSE20123 | FBXL19 | 54620 | 5 | 4 | 21 | |
| GSE43470 | FBXL19 | 54620 | 3 | 3 | 37 | |
| GSE46452 | FBXL19 | 54620 | 38 | 1 | 20 | |
| GSE47630 | FBXL19 | 54620 | 11 | 7 | 22 | |
| GSE54993 | FBXL19 | 54620 | 2 | 5 | 63 | |
| GSE54994 | FBXL19 | 54620 | 5 | 9 | 39 | |
| GSE60625 | FBXL19 | 54620 | 4 | 0 | 7 | |
| GSE74703 | FBXL19 | 54620 | 3 | 2 | 31 | |
| GSE74704 | FBXL19 | 54620 | 3 | 2 | 15 | |
| TCGA | FBXL19 | 54620 | 20 | 10 | 66 |
Total number of gains: 99; Total number of losses: 48; Total Number of normals: 341.
Somatic mutations of FBXL19:
Generating mutation plots.
Highly correlated genes for FBXL19:
Showing top 20/440 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FBXL19 | LTBR | 0.770818 | 3 | 0 | 3 |
| FBXL19 | PALB2 | 0.752827 | 3 | 0 | 3 |
| FBXL19 | RNF40 | 0.751109 | 5 | 0 | 5 |
| FBXL19 | MED26 | 0.747083 | 3 | 0 | 3 |
| FBXL19 | STARD10 | 0.740864 | 4 | 0 | 4 |
| FBXL19 | ARAP1 | 0.737902 | 3 | 0 | 3 |
| FBXL19 | NARS2 | 0.732647 | 3 | 0 | 3 |
| FBXL19 | PMM2 | 0.728235 | 5 | 0 | 5 |
| FBXL19 | DUT | 0.72686 | 3 | 0 | 3 |
| FBXL19 | CHCHD5 | 0.726525 | 3 | 0 | 3 |
| FBXL19 | MAGOHB | 0.725224 | 3 | 0 | 3 |
| FBXL19 | INO80E | 0.724353 | 6 | 0 | 6 |
| FBXL19 | PHKG2 | 0.72427 | 6 | 0 | 6 |
| FBXL19 | FAM32A | 0.724146 | 3 | 0 | 3 |
| FBXL19 | ZFYVE9 | 0.716239 | 4 | 0 | 4 |
| FBXL19 | RRP9 | 0.713089 | 4 | 0 | 4 |
| FBXL19 | PTPN6 | 0.709958 | 3 | 0 | 3 |
| FBXL19 | PLAGL2 | 0.70816 | 3 | 0 | 3 |
| FBXL19 | XXYLT1 | 0.706676 | 3 | 0 | 3 |
| FBXL19 | DNASE2 | 0.703838 | 3 | 0 | 3 |
For details and further investigation, click here
