| Full name: cytochrome P450 family 3 subfamily A member 43 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 7q22.1 | ||
| Entrez ID: 64816 | HGNC ID: HGNC:17450 | Ensembl Gene: ENSG00000021461 | OMIM ID: 606534 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of CYP3A43:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CYP3A43 | 64816 | 211442_x_at | -0.4373 | 0.0426 | |
| GSE20347 | CYP3A43 | 64816 | 211441_x_at | -0.3241 | 0.0128 | |
| GSE23400 | CYP3A43 | 64816 | 211440_x_at | -0.2449 | 0.0000 | |
| GSE26886 | CYP3A43 | 64816 | 211441_x_at | -0.3115 | 0.0157 | |
| GSE29001 | CYP3A43 | 64816 | 211442_x_at | -0.9578 | 0.0000 | |
| GSE38129 | CYP3A43 | 64816 | 211442_x_at | -0.4892 | 0.0000 | |
| GSE45670 | CYP3A43 | 64816 | 211442_x_at | -0.2974 | 0.0487 | |
| GSE63941 | CYP3A43 | 64816 | 211441_x_at | 0.1326 | 0.3496 | |
| GSE77861 | CYP3A43 | 64816 | 211441_x_at | -0.5300 | 0.0075 | |
| SRP133303 | CYP3A43 | 64816 | RNAseq | -0.1599 | 0.3817 | |
| TCGA | CYP3A43 | 64816 | RNAseq | -0.9010 | 0.3537 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CYP3A43 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of CYP3A43:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CYP3A43 | 64816 | 13 | 0 | 17 | |
| GSE20123 | CYP3A43 | 64816 | 13 | 0 | 17 | |
| GSE43470 | CYP3A43 | 64816 | 6 | 2 | 35 | |
| GSE46452 | CYP3A43 | 64816 | 11 | 1 | 47 | |
| GSE47630 | CYP3A43 | 64816 | 7 | 3 | 30 | |
| GSE54993 | CYP3A43 | 64816 | 1 | 9 | 60 | |
| GSE54994 | CYP3A43 | 64816 | 16 | 3 | 34 | |
| GSE60625 | CYP3A43 | 64816 | 0 | 0 | 11 | |
| GSE74703 | CYP3A43 | 64816 | 6 | 1 | 29 | |
| GSE74704 | CYP3A43 | 64816 | 9 | 0 | 11 | |
| TCGA | CYP3A43 | 64816 | 53 | 5 | 38 |
Total number of gains: 135; Total number of losses: 24; Total Number of normals: 329.
Somatic mutations of CYP3A43:
Generating mutation plots.
Highly correlated genes for CYP3A43:
Showing top 20/1724 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CYP3A43 | LINC00092 | 0.796939 | 3 | 0 | 3 |
| CYP3A43 | C5orf66-AS1 | 0.777529 | 4 | 0 | 4 |
| CYP3A43 | SNORA68 | 0.77197 | 4 | 0 | 4 |
| CYP3A43 | ASPG | 0.767759 | 3 | 0 | 3 |
| CYP3A43 | EIF4E3 | 0.736016 | 4 | 0 | 4 |
| CYP3A43 | FAM214A | 0.729158 | 4 | 0 | 4 |
| CYP3A43 | PCBP1-AS1 | 0.726386 | 3 | 0 | 3 |
| CYP3A43 | GALR3 | 0.724695 | 8 | 0 | 7 |
| CYP3A43 | SH3BGRL2 | 0.71874 | 4 | 0 | 3 |
| CYP3A43 | ANKRD18B | 0.718399 | 3 | 0 | 3 |
| CYP3A43 | FAM95B1 | 0.716914 | 4 | 0 | 3 |
| CYP3A43 | CTTNBP2 | 0.715861 | 4 | 0 | 3 |
| CYP3A43 | SMIM5 | 0.714937 | 4 | 0 | 4 |
| CYP3A43 | KRT32 | 0.713017 | 8 | 0 | 8 |
| CYP3A43 | PIWIL2 | 0.712105 | 6 | 0 | 6 |
| CYP3A43 | C20orf173 | 0.711688 | 3 | 0 | 3 |
| CYP3A43 | GPT2 | 0.711412 | 3 | 0 | 3 |
| CYP3A43 | LINC00957 | 0.70988 | 4 | 0 | 4 |
| CYP3A43 | SASH1 | 0.707861 | 8 | 0 | 8 |
| CYP3A43 | ARSE | 0.70764 | 3 | 0 | 3 |
For details and further investigation, click here
