| Full name: glutamic--pyruvic transaminase 2 | Alias Symbol: ALT2 | ||
| Type: protein-coding gene | Cytoband: 16q11.2 | ||
| Entrez ID: 84706 | HGNC ID: HGNC:18062 | Ensembl Gene: ENSG00000166123 | OMIM ID: 138210 |
| Drug and gene relationship at DGIdb | |||
Expression of GPT2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GPT2 | 84706 | 224839_s_at | -1.0298 | 0.3994 | |
| GSE26886 | GPT2 | 84706 | 224839_s_at | -3.2519 | 0.0000 | |
| GSE45670 | GPT2 | 84706 | 224839_s_at | -0.9839 | 0.0574 | |
| GSE53622 | GPT2 | 84706 | 151994 | -1.4629 | 0.0000 | |
| GSE53624 | GPT2 | 84706 | 151994 | -1.8573 | 0.0000 | |
| GSE63941 | GPT2 | 84706 | 224839_s_at | 1.6462 | 0.0086 | |
| GSE77861 | GPT2 | 84706 | 224839_s_at | -1.8202 | 0.0003 | |
| GSE97050 | GPT2 | 84706 | A_23_P37892 | 0.0200 | 0.9649 | |
| SRP007169 | GPT2 | 84706 | RNAseq | -3.3897 | 0.0000 | |
| SRP008496 | GPT2 | 84706 | RNAseq | -3.7029 | 0.0000 | |
| SRP064894 | GPT2 | 84706 | RNAseq | -2.8838 | 0.0000 | |
| SRP133303 | GPT2 | 84706 | RNAseq | -2.0552 | 0.0000 | |
| SRP159526 | GPT2 | 84706 | RNAseq | -2.0227 | 0.0000 | |
| SRP193095 | GPT2 | 84706 | RNAseq | -1.6684 | 0.0000 | |
| SRP219564 | GPT2 | 84706 | RNAseq | -3.4232 | 0.0000 | |
| TCGA | GPT2 | 84706 | RNAseq | -0.5364 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 11.
Survival by GPT2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GPT2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GPT2 | 84706 | 2 | 1 | 27 | |
| GSE20123 | GPT2 | 84706 | 2 | 1 | 27 | |
| GSE43470 | GPT2 | 84706 | 2 | 7 | 34 | |
| GSE46452 | GPT2 | 84706 | 38 | 1 | 20 | |
| GSE47630 | GPT2 | 84706 | 11 | 7 | 22 | |
| GSE54993 | GPT2 | 84706 | 2 | 5 | 63 | |
| GSE54994 | GPT2 | 84706 | 6 | 10 | 37 | |
| GSE60625 | GPT2 | 84706 | 4 | 0 | 7 | |
| GSE74703 | GPT2 | 84706 | 2 | 4 | 30 | |
| GSE74704 | GPT2 | 84706 | 2 | 1 | 17 | |
| TCGA | GPT2 | 84706 | 29 | 11 | 56 |
Total number of gains: 100; Total number of losses: 48; Total Number of normals: 340.
Somatic mutations of GPT2:
Generating mutation plots.
Highly correlated genes for GPT2:
Showing top 20/1120 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GPT2 | TMPRSS2 | 0.8137 | 5 | 0 | 5 |
| GPT2 | PCBP1-AS1 | 0.802034 | 3 | 0 | 3 |
| GPT2 | ANXA9 | 0.800767 | 6 | 0 | 6 |
| GPT2 | SPNS2 | 0.798458 | 5 | 0 | 5 |
| GPT2 | PSCA | 0.796342 | 4 | 0 | 4 |
| GPT2 | CYSRT1 | 0.789461 | 6 | 0 | 6 |
| GPT2 | CLIC3 | 0.789054 | 5 | 0 | 5 |
| GPT2 | CLINT1 | 0.784213 | 7 | 0 | 7 |
| GPT2 | FAM3D | 0.783158 | 7 | 0 | 7 |
| GPT2 | CAPN14 | 0.780627 | 6 | 0 | 6 |
| GPT2 | GPD1L | 0.773479 | 5 | 0 | 5 |
| GPT2 | SCNN1B | 0.773426 | 7 | 0 | 7 |
| GPT2 | EPS8L1 | 0.769491 | 7 | 0 | 7 |
| GPT2 | SORT1 | 0.768522 | 5 | 0 | 5 |
| GPT2 | SLC16A6 | 0.767794 | 7 | 0 | 6 |
| GPT2 | RANBP9 | 0.764435 | 7 | 0 | 7 |
| GPT2 | CXCL17 | 0.764189 | 7 | 0 | 7 |
| GPT2 | FBXO34 | 0.763968 | 5 | 0 | 5 |
| GPT2 | TTC39A | 0.763219 | 7 | 0 | 7 |
| GPT2 | GYS2 | 0.762744 | 6 | 0 | 6 |
For details and further investigation, click here
