| Full name: eukaryotic translation initiation factor 4E family member 3 | Alias Symbol: MGC39820 | ||
| Type: protein-coding gene | Cytoband: 3p13 | ||
| Entrez ID: 317649 | HGNC ID: HGNC:31837 | Ensembl Gene: ENSG00000163412 | OMIM ID: 609896 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of EIF4E3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EIF4E3 | 317649 | 225940_at | -1.1433 | 0.0451 | |
| GSE26886 | EIF4E3 | 317649 | 225941_at | -2.4697 | 0.0000 | |
| GSE45670 | EIF4E3 | 317649 | 225941_at | -1.4193 | 0.0000 | |
| GSE53622 | EIF4E3 | 317649 | 146487 | -1.6525 | 0.0000 | |
| GSE53624 | EIF4E3 | 317649 | 146487 | -1.7954 | 0.0000 | |
| GSE63941 | EIF4E3 | 317649 | 225940_at | 0.0269 | 0.9700 | |
| GSE77861 | EIF4E3 | 317649 | 225940_at | -1.0890 | 0.0003 | |
| GSE97050 | EIF4E3 | 317649 | A_24_P943113 | -1.3055 | 0.0762 | |
| SRP007169 | EIF4E3 | 317649 | RNAseq | -1.3093 | 0.0029 | |
| SRP008496 | EIF4E3 | 317649 | RNAseq | -1.3279 | 0.0000 | |
| SRP064894 | EIF4E3 | 317649 | RNAseq | -1.2706 | 0.0000 | |
| SRP133303 | EIF4E3 | 317649 | RNAseq | -0.8415 | 0.0023 | |
| SRP159526 | EIF4E3 | 317649 | RNAseq | -0.9326 | 0.0011 | |
| SRP193095 | EIF4E3 | 317649 | RNAseq | -1.1624 | 0.0000 | |
| SRP219564 | EIF4E3 | 317649 | RNAseq | -1.0639 | 0.0880 | |
| TCGA | EIF4E3 | 317649 | RNAseq | -0.5282 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 10.
Survival by EIF4E3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EIF4E3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EIF4E3 | 317649 | 1 | 20 | 9 | |
| GSE20123 | EIF4E3 | 317649 | 1 | 20 | 9 | |
| GSE43470 | EIF4E3 | 317649 | 0 | 21 | 22 | |
| GSE46452 | EIF4E3 | 317649 | 2 | 17 | 40 | |
| GSE47630 | EIF4E3 | 317649 | 1 | 23 | 16 | |
| GSE54993 | EIF4E3 | 317649 | 5 | 3 | 62 | |
| GSE54994 | EIF4E3 | 317649 | 1 | 33 | 19 | |
| GSE60625 | EIF4E3 | 317649 | 3 | 1 | 7 | |
| GSE74703 | EIF4E3 | 317649 | 0 | 17 | 19 | |
| GSE74704 | EIF4E3 | 317649 | 1 | 13 | 6 | |
| TCGA | EIF4E3 | 317649 | 1 | 79 | 16 |
Total number of gains: 16; Total number of losses: 247; Total Number of normals: 225.
Somatic mutations of EIF4E3:
Generating mutation plots.
Highly correlated genes for EIF4E3:
Showing top 20/1898 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EIF4E3 | ANGPTL1 | 0.848651 | 5 | 0 | 5 |
| EIF4E3 | CASQ2 | 0.84226 | 5 | 0 | 5 |
| EIF4E3 | CLEC3B | 0.837581 | 3 | 0 | 3 |
| EIF4E3 | FXYD1 | 0.832167 | 3 | 0 | 3 |
| EIF4E3 | CAB39L | 0.829272 | 7 | 0 | 7 |
| EIF4E3 | SORT1 | 0.825724 | 7 | 0 | 7 |
| EIF4E3 | MEIS1 | 0.825023 | 7 | 0 | 7 |
| EIF4E3 | LDB3 | 0.82317 | 5 | 0 | 5 |
| EIF4E3 | CHRDL1 | 0.821179 | 4 | 0 | 4 |
| EIF4E3 | ACOX3 | 0.820998 | 6 | 0 | 6 |
| EIF4E3 | LRRK2 | 0.819897 | 7 | 0 | 7 |
| EIF4E3 | OGN | 0.812305 | 5 | 0 | 5 |
| EIF4E3 | ZBTB16 | 0.809855 | 4 | 0 | 4 |
| EIF4E3 | MPC1 | 0.806836 | 6 | 0 | 6 |
| EIF4E3 | HLF | 0.805487 | 7 | 0 | 7 |
| EIF4E3 | MRPL39 | 0.804736 | 4 | 0 | 4 |
| EIF4E3 | PCP4 | 0.804116 | 5 | 0 | 5 |
| EIF4E3 | HPGD | 0.802208 | 7 | 0 | 7 |
| EIF4E3 | ITGA9 | 0.801119 | 5 | 0 | 5 |
| EIF4E3 | CITED2 | 0.800049 | 7 | 0 | 7 |
For details and further investigation, click here
