| Full name: DNA damage inducible transcript 4 like | Alias Symbol: REDD2|Rtp801L | ||
| Type: protein-coding gene | Cytoband: 4q24 | ||
| Entrez ID: 115265 | HGNC ID: HGNC:30555 | Ensembl Gene: ENSG00000145358 | OMIM ID: 607730 |
| Drug and gene relationship at DGIdb | |||
Expression of DDIT4L:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DDIT4L | 115265 | 228057_at | -0.1532 | 0.7202 | |
| GSE26886 | DDIT4L | 115265 | 228057_at | 0.5741 | 0.1711 | |
| GSE45670 | DDIT4L | 115265 | 228057_at | -0.6254 | 0.0000 | |
| GSE53622 | DDIT4L | 115265 | 1565 | -0.3200 | 0.0014 | |
| GSE53624 | DDIT4L | 115265 | 1565 | -0.2655 | 0.0083 | |
| GSE63941 | DDIT4L | 115265 | 228057_at | -3.6461 | 0.0006 | |
| GSE77861 | DDIT4L | 115265 | 228057_at | -0.0351 | 0.7226 | |
| GSE97050 | DDIT4L | 115265 | A_33_P3372099 | -0.4692 | 0.2992 | |
| SRP133303 | DDIT4L | 115265 | RNAseq | -1.2919 | 0.0169 | |
| TCGA | DDIT4L | 115265 | RNAseq | -0.5830 | 0.1661 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by DDIT4L expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DDIT4L:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DDIT4L | 115265 | 0 | 12 | 18 | |
| GSE20123 | DDIT4L | 115265 | 0 | 12 | 18 | |
| GSE43470 | DDIT4L | 115265 | 0 | 13 | 30 | |
| GSE46452 | DDIT4L | 115265 | 1 | 36 | 22 | |
| GSE47630 | DDIT4L | 115265 | 0 | 20 | 20 | |
| GSE54993 | DDIT4L | 115265 | 9 | 0 | 61 | |
| GSE54994 | DDIT4L | 115265 | 1 | 11 | 41 | |
| GSE60625 | DDIT4L | 115265 | 0 | 3 | 8 | |
| GSE74703 | DDIT4L | 115265 | 0 | 11 | 25 | |
| GSE74704 | DDIT4L | 115265 | 0 | 6 | 14 | |
| TCGA | DDIT4L | 115265 | 8 | 40 | 48 |
Total number of gains: 19; Total number of losses: 164; Total Number of normals: 305.
Somatic mutations of DDIT4L:
Generating mutation plots.
Highly correlated genes for DDIT4L:
Showing top 20/378 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DDIT4L | MAP3K7CL | 0.750233 | 3 | 0 | 3 |
| DDIT4L | MGARP | 0.746817 | 3 | 0 | 3 |
| DDIT4L | GDNF | 0.74057 | 3 | 0 | 3 |
| DDIT4L | FIBIN | 0.738359 | 3 | 0 | 3 |
| DDIT4L | FGL2 | 0.729543 | 4 | 0 | 4 |
| DDIT4L | PGR | 0.726007 | 5 | 0 | 5 |
| DDIT4L | ITGB1BP2 | 0.722574 | 3 | 0 | 3 |
| DDIT4L | MAMLD1 | 0.69901 | 3 | 0 | 3 |
| DDIT4L | ATP8A2 | 0.68597 | 3 | 0 | 3 |
| DDIT4L | DIXDC1 | 0.685318 | 5 | 0 | 5 |
| DDIT4L | FBLN7 | 0.681214 | 3 | 0 | 3 |
| DDIT4L | GPR146 | 0.677815 | 3 | 0 | 3 |
| DDIT4L | MAG | 0.675357 | 3 | 0 | 3 |
| DDIT4L | DACT3 | 0.674103 | 8 | 0 | 7 |
| DDIT4L | SNAP91 | 0.668386 | 4 | 0 | 3 |
| DDIT4L | ITIH3 | 0.667413 | 4 | 0 | 3 |
| DDIT4L | CA4 | 0.666767 | 3 | 0 | 3 |
| DDIT4L | MAGI2-AS3 | 0.664441 | 6 | 0 | 5 |
| DDIT4L | LINC01279 | 0.66436 | 5 | 0 | 4 |
| DDIT4L | HEBP1 | 0.663057 | 4 | 0 | 3 |
For details and further investigation, click here
