| Full name: progesterone receptor | Alias Symbol: PR|NR3C3 | ||
| Type: protein-coding gene | Cytoband: 11q22.1 | ||
| Entrez ID: 5241 | HGNC ID: HGNC:8910 | Ensembl Gene: ENSG00000082175 | OMIM ID: 607311 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
PGR involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04114 | Oocyte meiosis | |
| hsa04914 | Progesterone-mediated oocyte maturation |
Expression of PGR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PGR | 5241 | 228554_at | -1.4088 | 0.2312 | |
| GSE20347 | PGR | 5241 | 208305_at | 0.1082 | 0.3437 | |
| GSE23400 | PGR | 5241 | 208305_at | -0.0698 | 0.0010 | |
| GSE26886 | PGR | 5241 | 228554_at | 0.5252 | 0.2703 | |
| GSE29001 | PGR | 5241 | 208305_at | -0.1374 | 0.1692 | |
| GSE38129 | PGR | 5241 | 208305_at | -0.0056 | 0.9633 | |
| GSE45670 | PGR | 5241 | 228554_at | -1.7518 | 0.0000 | |
| GSE53622 | PGR | 5241 | 84330 | -0.9151 | 0.0000 | |
| GSE53624 | PGR | 5241 | 84330 | -0.9394 | 0.0000 | |
| GSE63941 | PGR | 5241 | 228554_at | -0.2713 | 0.2253 | |
| GSE77861 | PGR | 5241 | 228554_at | 0.0547 | 0.6049 | |
| GSE97050 | PGR | 5241 | A_23_P138938 | -0.6086 | 0.1506 | |
| SRP064894 | PGR | 5241 | RNAseq | -0.2978 | 0.4519 | |
| SRP133303 | PGR | 5241 | RNAseq | -0.6588 | 0.1676 | |
| SRP159526 | PGR | 5241 | RNAseq | -0.5557 | 0.4374 | |
| SRP219564 | PGR | 5241 | RNAseq | -1.5946 | 0.1369 | |
| TCGA | PGR | 5241 | RNAseq | -0.9510 | 0.0020 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by PGR expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PGR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PGR | 5241 | 4 | 9 | 17 | |
| GSE20123 | PGR | 5241 | 4 | 9 | 17 | |
| GSE43470 | PGR | 5241 | 5 | 5 | 33 | |
| GSE46452 | PGR | 5241 | 5 | 24 | 30 | |
| GSE47630 | PGR | 5241 | 2 | 19 | 19 | |
| GSE54993 | PGR | 5241 | 8 | 3 | 59 | |
| GSE54994 | PGR | 5241 | 6 | 18 | 29 | |
| GSE60625 | PGR | 5241 | 0 | 3 | 8 | |
| GSE74703 | PGR | 5241 | 3 | 4 | 29 | |
| GSE74704 | PGR | 5241 | 4 | 5 | 11 | |
| TCGA | PGR | 5241 | 10 | 44 | 42 |
Total number of gains: 51; Total number of losses: 143; Total Number of normals: 294.
Somatic mutations of PGR:
Generating mutation plots.
Highly correlated genes for PGR:
Showing top 20/932 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PGR | FXYD1 | 0.893707 | 3 | 0 | 3 |
| PGR | SORCS1 | 0.874189 | 4 | 0 | 4 |
| PGR | ADAMTSL1 | 0.853812 | 5 | 0 | 5 |
| PGR | SGCA | 0.843457 | 6 | 0 | 6 |
| PGR | C1QTNF7 | 0.841379 | 5 | 0 | 5 |
| PGR | SLIT2 | 0.832409 | 5 | 0 | 5 |
| PGR | PPP1R14A | 0.831443 | 5 | 0 | 5 |
| PGR | PLN | 0.831198 | 5 | 0 | 5 |
| PGR | IQUB | 0.826404 | 3 | 0 | 3 |
| PGR | MAMDC2 | 0.818951 | 5 | 0 | 5 |
| PGR | ILDR2 | 0.816748 | 3 | 0 | 3 |
| PGR | MYOM1 | 0.816734 | 5 | 0 | 5 |
| PGR | ANO5 | 0.811971 | 6 | 0 | 6 |
| PGR | ASB5 | 0.810916 | 5 | 0 | 5 |
| PGR | MYOCD | 0.809521 | 5 | 0 | 5 |
| PGR | ITGA7 | 0.808419 | 5 | 0 | 5 |
| PGR | LPP | 0.807258 | 5 | 0 | 5 |
| PGR | PARD3B | 0.806267 | 4 | 0 | 4 |
| PGR | AOC3 | 0.805653 | 5 | 0 | 5 |
| PGR | PTCHD1 | 0.805385 | 5 | 0 | 5 |
For details and further investigation, click here
