| Full name: carbonic anhydrase 4 | Alias Symbol: CAIV|Car4 | ||
| Type: protein-coding gene | Cytoband: 17q23.1 | ||
| Entrez ID: 762 | HGNC ID: HGNC:1375 | Ensembl Gene: ENSG00000167434 | OMIM ID: 114760 |
| Drug and gene relationship at DGIdb | |||
Expression of CA4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CA4 | 762 | 206208_at | -0.2165 | 0.5619 | |
| GSE20347 | CA4 | 762 | 206208_at | -0.1968 | 0.0147 | |
| GSE23400 | CA4 | 762 | 206208_at | -0.1940 | 0.0000 | |
| GSE26886 | CA4 | 762 | 206208_at | 0.1407 | 0.4025 | |
| GSE29001 | CA4 | 762 | 206209_s_at | -0.2831 | 0.0268 | |
| GSE38129 | CA4 | 762 | 206208_at | -0.4183 | 0.0000 | |
| GSE45670 | CA4 | 762 | 206208_at | -0.1912 | 0.0608 | |
| GSE53622 | CA4 | 762 | 3649 | -0.3728 | 0.0026 | |
| GSE53624 | CA4 | 762 | 3649 | -0.7314 | 0.0000 | |
| GSE63941 | CA4 | 762 | 206208_at | 0.0128 | 0.9541 | |
| GSE77861 | CA4 | 762 | 206208_at | -0.2393 | 0.2297 | |
| GSE97050 | CA4 | 762 | A_23_P4096 | -0.4944 | 0.2096 | |
| TCGA | CA4 | 762 | RNAseq | -5.2091 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by CA4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CA4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CA4 | 762 | 5 | 1 | 24 | |
| GSE20123 | CA4 | 762 | 5 | 1 | 24 | |
| GSE43470 | CA4 | 762 | 5 | 0 | 38 | |
| GSE46452 | CA4 | 762 | 32 | 0 | 27 | |
| GSE47630 | CA4 | 762 | 7 | 1 | 32 | |
| GSE54993 | CA4 | 762 | 2 | 5 | 63 | |
| GSE54994 | CA4 | 762 | 9 | 5 | 39 | |
| GSE60625 | CA4 | 762 | 4 | 0 | 7 | |
| GSE74703 | CA4 | 762 | 5 | 0 | 31 | |
| GSE74704 | CA4 | 762 | 4 | 1 | 15 | |
| TCGA | CA4 | 762 | 29 | 7 | 60 |
Total number of gains: 107; Total number of losses: 21; Total Number of normals: 360.
Somatic mutations of CA4:
Generating mutation plots.
Highly correlated genes for CA4:
Showing top 20/771 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CA4 | TXNDC2 | 0.78153 | 3 | 0 | 3 |
| CA4 | PSPN | 0.774497 | 4 | 0 | 4 |
| CA4 | NAT8B | 0.76664 | 3 | 0 | 3 |
| CA4 | DHRS7C | 0.758563 | 3 | 0 | 3 |
| CA4 | CDC42EP2 | 0.754706 | 4 | 0 | 3 |
| CA4 | KLHL10 | 0.736832 | 4 | 0 | 3 |
| CA4 | OSBPL5 | 0.736393 | 3 | 0 | 3 |
| CA4 | SLC35F3 | 0.718414 | 3 | 0 | 3 |
| CA4 | KIF6 | 0.715888 | 3 | 0 | 3 |
| CA4 | B3GNT8 | 0.714062 | 3 | 0 | 3 |
| CA4 | HHIP | 0.704833 | 4 | 0 | 4 |
| CA4 | NXNL1 | 0.699919 | 3 | 0 | 3 |
| CA4 | TSSK3 | 0.698353 | 3 | 0 | 3 |
| CA4 | GALR2 | 0.697742 | 4 | 0 | 3 |
| CA4 | GPR78 | 0.695704 | 3 | 0 | 3 |
| CA4 | ZGLP1 | 0.692467 | 3 | 0 | 3 |
| CA4 | NCR3 | 0.689663 | 4 | 0 | 4 |
| CA4 | CLCNKB | 0.688249 | 5 | 0 | 4 |
| CA4 | MYO1A | 0.686782 | 7 | 0 | 5 |
| CA4 | COX4I2 | 0.686646 | 3 | 0 | 3 |
For details and further investigation, click here
