| Full name: inter-alpha-trypsin inhibitor heavy chain 3 | Alias Symbol: H3P | ||
| Type: protein-coding gene | Cytoband: 3p21.1 | ||
| Entrez ID: 3699 | HGNC ID: HGNC:6168 | Ensembl Gene: ENSG00000162267 | OMIM ID: 146650 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of ITIH3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ITIH3 | 3699 | 205755_at | -0.0747 | 0.8834 | |
| GSE20347 | ITIH3 | 3699 | 205755_at | -0.0289 | 0.7054 | |
| GSE23400 | ITIH3 | 3699 | 205755_at | -0.1990 | 0.0000 | |
| GSE26886 | ITIH3 | 3699 | 205755_at | 0.2553 | 0.0435 | |
| GSE29001 | ITIH3 | 3699 | 205755_at | -0.0888 | 0.4749 | |
| GSE38129 | ITIH3 | 3699 | 205755_at | -0.2826 | 0.0307 | |
| GSE45670 | ITIH3 | 3699 | 205755_at | -0.7721 | 0.0000 | |
| GSE53622 | ITIH3 | 3699 | 37971 | -0.5271 | 0.0000 | |
| GSE53624 | ITIH3 | 3699 | 37971 | -0.8432 | 0.0000 | |
| GSE63941 | ITIH3 | 3699 | 205755_at | -0.1793 | 0.2425 | |
| GSE77861 | ITIH3 | 3699 | 205755_at | -0.1634 | 0.0482 | |
| GSE97050 | ITIH3 | 3699 | A_33_P3313145 | -0.0047 | 0.9891 | |
| SRP064894 | ITIH3 | 3699 | RNAseq | -1.4302 | 0.0016 | |
| SRP133303 | ITIH3 | 3699 | RNAseq | -2.6801 | 0.0000 | |
| SRP159526 | ITIH3 | 3699 | RNAseq | -2.0908 | 0.0025 | |
| SRP219564 | ITIH3 | 3699 | RNAseq | -0.8186 | 0.1436 | |
| TCGA | ITIH3 | 3699 | RNAseq | -1.9127 | 0.0028 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by ITIH3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ITIH3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ITIH3 | 3699 | 0 | 18 | 12 | |
| GSE20123 | ITIH3 | 3699 | 0 | 19 | 11 | |
| GSE43470 | ITIH3 | 3699 | 0 | 18 | 25 | |
| GSE46452 | ITIH3 | 3699 | 2 | 17 | 40 | |
| GSE47630 | ITIH3 | 3699 | 1 | 24 | 15 | |
| GSE54993 | ITIH3 | 3699 | 6 | 2 | 62 | |
| GSE54994 | ITIH3 | 3699 | 0 | 33 | 20 | |
| GSE60625 | ITIH3 | 3699 | 5 | 0 | 6 | |
| GSE74703 | ITIH3 | 3699 | 0 | 14 | 22 | |
| GSE74704 | ITIH3 | 3699 | 0 | 12 | 8 | |
| TCGA | ITIH3 | 3699 | 0 | 78 | 18 |
Total number of gains: 14; Total number of losses: 235; Total Number of normals: 239.
Somatic mutations of ITIH3:
Generating mutation plots.
Highly correlated genes for ITIH3:
Showing top 20/520 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ITIH3 | STAC2 | 0.760955 | 3 | 0 | 3 |
| ITIH3 | CRB2 | 0.748529 | 3 | 0 | 3 |
| ITIH3 | BPIFB4 | 0.743357 | 3 | 0 | 3 |
| ITIH3 | NOG | 0.734482 | 3 | 0 | 3 |
| ITIH3 | DHRS7C | 0.734393 | 3 | 0 | 3 |
| ITIH3 | ALPL | 0.724526 | 3 | 0 | 3 |
| ITIH3 | C1QL1 | 0.716958 | 4 | 0 | 4 |
| ITIH3 | DLK2 | 0.712223 | 3 | 0 | 3 |
| ITIH3 | TMEM179 | 0.709541 | 3 | 0 | 3 |
| ITIH3 | C20orf173 | 0.708203 | 4 | 0 | 4 |
| ITIH3 | CORT | 0.707458 | 3 | 0 | 3 |
| ITIH3 | PANX2 | 0.706393 | 3 | 0 | 3 |
| ITIH3 | COX4I2 | 0.705931 | 4 | 0 | 3 |
| ITIH3 | PHOSPHO1 | 0.705347 | 4 | 0 | 4 |
| ITIH3 | PALM3 | 0.704984 | 4 | 0 | 4 |
| ITIH3 | PROCA1 | 0.702019 | 3 | 0 | 3 |
| ITIH3 | SLC2A11 | 0.699895 | 3 | 0 | 3 |
| ITIH3 | OR1J4 | 0.695764 | 3 | 0 | 3 |
| ITIH3 | ZFPM1 | 0.694312 | 3 | 0 | 3 |
| ITIH3 | LRTM2 | 0.690732 | 4 | 0 | 4 |
For details and further investigation, click here
