| Full name: glial cell derived neurotrophic factor | Alias Symbol: ATF1|ATF2|HFB1-GDNF | ||
| Type: protein-coding gene | Cytoband: 5p13.2 | ||
| Entrez ID: 2668 | HGNC ID: HGNC:4232 | Ensembl Gene: ENSG00000168621 | OMIM ID: 600837 |
| Drug and gene relationship at DGIdb | |||
Expression of GDNF:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GDNF | 2668 | 230090_at | -0.2201 | 0.7383 | |
| GSE20347 | GDNF | 2668 | 221359_at | -0.0364 | 0.5969 | |
| GSE23400 | GDNF | 2668 | 221359_at | -0.1549 | 0.0000 | |
| GSE26886 | GDNF | 2668 | 221359_at | 0.1333 | 0.1783 | |
| GSE29001 | GDNF | 2668 | 221359_at | -0.0421 | 0.8219 | |
| GSE38129 | GDNF | 2668 | 221359_at | -0.1231 | 0.0205 | |
| GSE45670 | GDNF | 2668 | 221359_at | -0.0136 | 0.8332 | |
| GSE53622 | GDNF | 2668 | 11700 | 0.1310 | 0.2624 | |
| GSE53624 | GDNF | 2668 | 11700 | 0.2060 | 0.0175 | |
| GSE63941 | GDNF | 2668 | 230090_at | -0.6788 | 0.0050 | |
| GSE77861 | GDNF | 2668 | 221359_at | -0.0567 | 0.5237 | |
| GSE97050 | GDNF | 2668 | A_33_P3268892 | -0.5090 | 0.2641 | |
| SRP064894 | GDNF | 2668 | RNAseq | 0.3128 | 0.3423 | |
| SRP133303 | GDNF | 2668 | RNAseq | 0.2175 | 0.4282 | |
| SRP159526 | GDNF | 2668 | RNAseq | 1.1557 | 0.0886 | |
| SRP193095 | GDNF | 2668 | RNAseq | 0.2739 | 0.1176 | |
| SRP219564 | GDNF | 2668 | RNAseq | -0.2402 | 0.8247 | |
| TCGA | GDNF | 2668 | RNAseq | -0.6373 | 0.2785 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by GDNF expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GDNF:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GDNF | 2668 | 10 | 0 | 20 | |
| GSE20123 | GDNF | 2668 | 10 | 0 | 20 | |
| GSE43470 | GDNF | 2668 | 18 | 0 | 25 | |
| GSE46452 | GDNF | 2668 | 5 | 22 | 32 | |
| GSE47630 | GDNF | 2668 | 6 | 12 | 22 | |
| GSE54993 | GDNF | 2668 | 5 | 4 | 61 | |
| GSE54994 | GDNF | 2668 | 25 | 2 | 26 | |
| GSE60625 | GDNF | 2668 | 0 | 0 | 11 | |
| GSE74703 | GDNF | 2668 | 14 | 0 | 22 | |
| GSE74704 | GDNF | 2668 | 9 | 0 | 11 | |
| TCGA | GDNF | 2668 | 52 | 6 | 38 |
Total number of gains: 154; Total number of losses: 46; Total Number of normals: 288.
Somatic mutations of GDNF:
Generating mutation plots.
Highly correlated genes for GDNF:
Showing top 20/627 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GDNF | NRXN1 | 0.753739 | 3 | 0 | 3 |
| GDNF | SP7 | 0.751346 | 3 | 0 | 3 |
| GDNF | DDIT4L | 0.74057 | 3 | 0 | 3 |
| GDNF | OLIG3 | 0.717282 | 3 | 0 | 3 |
| GDNF | TSKS | 0.711273 | 3 | 0 | 3 |
| GDNF | MYEF2 | 0.706097 | 4 | 0 | 4 |
| GDNF | LAMA2 | 0.696541 | 3 | 0 | 3 |
| GDNF | HMCN2 | 0.693972 | 3 | 0 | 3 |
| GDNF | MYT1L | 0.692946 | 3 | 0 | 3 |
| GDNF | EPHA7 | 0.686315 | 3 | 0 | 3 |
| GDNF | SHISA4 | 0.68432 | 4 | 0 | 4 |
| GDNF | TMEM132D | 0.68253 | 3 | 0 | 3 |
| GDNF | ADAMTS19 | 0.678194 | 5 | 0 | 3 |
| GDNF | SOX3 | 0.677155 | 4 | 0 | 4 |
| GDNF | FMR1NB | 0.67685 | 3 | 0 | 3 |
| GDNF | SFRP5 | 0.672807 | 3 | 0 | 3 |
| GDNF | NRK | 0.671616 | 4 | 0 | 3 |
| GDNF | SSC5D | 0.671289 | 3 | 0 | 3 |
| GDNF | PPP1R12C | 0.670137 | 5 | 0 | 4 |
| GDNF | PTPRR | 0.669448 | 3 | 0 | 3 |
For details and further investigation, click here
