| Full name: SIX homeobox 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2p21 | ||
| Entrez ID: 10736 | HGNC ID: HGNC:10888 | Ensembl Gene: ENSG00000170577 | OMIM ID: 604994 |
| Drug and gene relationship at DGIdb | |||
Expression of SIX2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SIX2 | 10736 | 206510_at | 0.8463 | 0.4665 | |
| GSE20347 | SIX2 | 10736 | 206510_at | 0.1464 | 0.1053 | |
| GSE23400 | SIX2 | 10736 | 206510_at | 0.0567 | 0.3599 | |
| GSE26886 | SIX2 | 10736 | 206510_at | 0.8305 | 0.0013 | |
| GSE29001 | SIX2 | 10736 | 206510_at | 1.0103 | 0.0131 | |
| GSE38129 | SIX2 | 10736 | 206510_at | 0.3633 | 0.0293 | |
| GSE45670 | SIX2 | 10736 | 206510_at | 0.2351 | 0.0981 | |
| GSE53622 | SIX2 | 10736 | 4022 | 1.6988 | 0.0000 | |
| GSE53624 | SIX2 | 10736 | 4022 | 1.6556 | 0.0000 | |
| GSE63941 | SIX2 | 10736 | 206510_at | 1.2992 | 0.1733 | |
| GSE77861 | SIX2 | 10736 | 206511_s_at | -0.0556 | 0.7808 | |
| GSE97050 | SIX2 | 10736 | A_23_P28120 | -0.0865 | 0.7772 | |
| SRP159526 | SIX2 | 10736 | RNAseq | 4.5909 | 0.0000 | |
| SRP219564 | SIX2 | 10736 | RNAseq | 5.1023 | 0.0000 | |
| TCGA | SIX2 | 10736 | RNAseq | 1.0938 | 0.0028 |
Upregulated datasets: 6; Downregulated datasets: 0.
Survival by SIX2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SIX2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SIX2 | 10736 | 10 | 1 | 19 | |
| GSE20123 | SIX2 | 10736 | 9 | 1 | 20 | |
| GSE43470 | SIX2 | 10736 | 5 | 0 | 38 | |
| GSE46452 | SIX2 | 10736 | 1 | 4 | 54 | |
| GSE47630 | SIX2 | 10736 | 7 | 0 | 33 | |
| GSE54993 | SIX2 | 10736 | 0 | 5 | 65 | |
| GSE54994 | SIX2 | 10736 | 10 | 0 | 43 | |
| GSE60625 | SIX2 | 10736 | 0 | 3 | 8 | |
| GSE74703 | SIX2 | 10736 | 5 | 0 | 31 | |
| GSE74704 | SIX2 | 10736 | 9 | 1 | 10 | |
| TCGA | SIX2 | 10736 | 35 | 2 | 59 |
Total number of gains: 91; Total number of losses: 17; Total Number of normals: 380.
Somatic mutations of SIX2:
Generating mutation plots.
Highly correlated genes for SIX2:
Showing top 20/141 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SIX2 | NR2E1 | 0.730077 | 3 | 0 | 3 |
| SIX2 | SLCO1B1 | 0.727762 | 3 | 0 | 3 |
| SIX2 | ADAMTS17 | 0.706513 | 3 | 0 | 3 |
| SIX2 | C7orf26 | 0.685754 | 4 | 0 | 4 |
| SIX2 | FAM24B | 0.674194 | 3 | 0 | 3 |
| SIX2 | PRR15 | 0.672675 | 4 | 0 | 3 |
| SIX2 | ZNF511 | 0.66761 | 4 | 0 | 3 |
| SIX2 | UROD | 0.659611 | 3 | 0 | 3 |
| SIX2 | HOXC9 | 0.657674 | 4 | 0 | 4 |
| SIX2 | ARHGAP22 | 0.655744 | 4 | 0 | 3 |
| SIX2 | SDCCAG8 | 0.655464 | 4 | 0 | 3 |
| SIX2 | LRFN2 | 0.654324 | 3 | 0 | 3 |
| SIX2 | DDX49 | 0.651847 | 5 | 0 | 4 |
| SIX2 | MIB2 | 0.651356 | 3 | 0 | 3 |
| SIX2 | LAMTOR2 | 0.651137 | 4 | 0 | 4 |
| SIX2 | LRFN4 | 0.648457 | 6 | 0 | 6 |
| SIX2 | ZBTB48 | 0.643097 | 4 | 0 | 3 |
| SIX2 | DUSP9 | 0.638282 | 5 | 0 | 5 |
| SIX2 | PGP | 0.634482 | 4 | 0 | 3 |
| SIX2 | C19orf53 | 0.622858 | 5 | 0 | 3 |
For details and further investigation, click here
