TRPM2

 

Full name: transient receptor potential cation channel subfamily M member 2 Alias Symbol: KNP3|LTRPC2|NUDT9L1|NUDT9H|EREG1
Type: protein-coding gene Cytoband: 21q22.3
Entrez ID: 7226 HGNC ID: HGNC:12339 Ensembl Gene: ENSG00000142185 OMIM ID: 603749
Drug and gene relationship at DGIdb

 

TRPM2 involved pathways:

KEGG pathway Description View
hsa04921Oxytocin signaling pathway

 

Expression of TRPM2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TRPM2 7226 205708_s_at 0.5807 0.2526
GSE20347 TRPM2 7226 205708_s_at 0.2277 0.0157
GSE23400 TRPM2 7226 205708_s_at 0.0914 0.0468
GSE26886 TRPM2 7226 205708_s_at 0.3306 0.0323
GSE29001 TRPM2 7226 205708_s_at 0.0975 0.5491
GSE38129 TRPM2 7226 205708_s_at 0.2808 0.0076
GSE45670 TRPM2 7226 205708_s_at 0.4388 0.0001
GSE53622 TRPM2 7226 88490 0.7860 0.0000
GSE53624 TRPM2 7226 88490 1.3560 0.0000
GSE63941 TRPM2 7226 205708_s_at 0.7962 0.0360
GSE77861 TRPM2 7226 205708_s_at 0.0738 0.6476
SRP064894 TRPM2 7226 RNAseq 2.5293 0.0000
SRP133303 TRPM2 7226 RNAseq 1.3136 0.0000
SRP159526 TRPM2 7226 RNAseq 1.4655 0.0012
SRP193095 TRPM2 7226 RNAseq 1.8274 0.0000
SRP219564 TRPM2 7226 RNAseq 1.8678 0.0006
TCGA TRPM2 7226 RNAseq 0.6749 0.0000

Upregulated datasets: 6; Downregulated datasets: 0.  

 

Survival by TRPM2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of TRPM2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TRPM2 7226 2 8 20
GSE20123 TRPM2 7226 2 8 20
GSE43470 TRPM2 7226 0 13 30
GSE46452 TRPM2 7226 1 21 37
GSE47630 TRPM2 7226 6 17 17
GSE54993 TRPM2 7226 8 1 61
GSE54994 TRPM2 7226 4 8 41
GSE60625 TRPM2 7226 0 0 11
GSE74703 TRPM2 7226 0 10 26
GSE74704 TRPM2 7226 1 4 15
TCGA TRPM2 7226 9 38 49

Total number of gains: 33; Total number of losses: 128; Total Number of normals: 327.  

 

Somatic mutations of TRPM2:

 

Generating mutation plots.

 

Highly correlated genes for TRPM2:

 

Showing top 20/501 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TRPM2DDX490.729624303
TRPM2SBK10.720252303
TRPM2SLC39A30.704276303
TRPM2MYPOP0.681915505
TRPM2CEMP10.672949303
TRPM2TMED10.662812504
TRPM2MEX3D0.654959403
TRPM2LSAMP-AS10.652241303
TRPM2ANKRD13B0.649054303
TRPM2PELI30.644366303
TRPM2SMKR10.643682303
TRPM2SLC45A30.642092403
TRPM2ZNF6680.637987303
TRPM2GAS2L30.628606303
TRPM2MTFR20.624759404
TRPM2CEBPE0.622642303
TRPM2EGR40.620991403
TRPM2TSEN540.620806404
TRPM2CDC370.619036403
TRPM2GSK3A0.617867505

For details and further investigation, click here