| Full name: HPS1 biogenesis of lysosomal organelles complex 3 subunit 1 | Alias Symbol: BLOC3S1 | ||
| Type: protein-coding gene | Cytoband: 10q24.2 | ||
| Entrez ID: 3257 | HGNC ID: HGNC:5163 | Ensembl Gene: ENSG00000107521 | OMIM ID: 604982 |
| Drug and gene relationship at DGIdb | |||
Expression of HPS1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HPS1 | 3257 | 203308_x_at | 0.0598 | 0.9044 | |
| GSE20347 | HPS1 | 3257 | 203308_x_at | 0.0629 | 0.6320 | |
| GSE23400 | HPS1 | 3257 | 203308_x_at | -0.0333 | 0.3523 | |
| GSE26886 | HPS1 | 3257 | 203308_x_at | -0.1419 | 0.2808 | |
| GSE29001 | HPS1 | 3257 | 203309_s_at | -0.0554 | 0.8597 | |
| GSE38129 | HPS1 | 3257 | 203308_x_at | -0.0399 | 0.6793 | |
| GSE45670 | HPS1 | 3257 | 203308_x_at | 0.0528 | 0.5829 | |
| GSE53622 | HPS1 | 3257 | 15798 | -0.1347 | 0.0247 | |
| GSE53624 | HPS1 | 3257 | 15798 | 0.4132 | 0.0000 | |
| GSE63941 | HPS1 | 3257 | 210112_at | 0.0383 | 0.9238 | |
| GSE77861 | HPS1 | 3257 | 203308_x_at | -0.0412 | 0.8624 | |
| GSE97050 | HPS1 | 3257 | A_33_P3412479 | 0.1934 | 0.3781 | |
| SRP007169 | HPS1 | 3257 | RNAseq | 0.2389 | 0.5361 | |
| SRP008496 | HPS1 | 3257 | RNAseq | 0.0371 | 0.9054 | |
| SRP064894 | HPS1 | 3257 | RNAseq | 0.1746 | 0.3485 | |
| SRP133303 | HPS1 | 3257 | RNAseq | -0.0367 | 0.7497 | |
| SRP159526 | HPS1 | 3257 | RNAseq | 0.0069 | 0.9778 | |
| SRP193095 | HPS1 | 3257 | RNAseq | 0.0414 | 0.7632 | |
| SRP219564 | HPS1 | 3257 | RNAseq | 0.1861 | 0.4957 | |
| TCGA | HPS1 | 3257 | RNAseq | -0.1386 | 0.0029 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HPS1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HPS1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HPS1 | 3257 | 1 | 8 | 21 | |
| GSE20123 | HPS1 | 3257 | 1 | 7 | 22 | |
| GSE43470 | HPS1 | 3257 | 0 | 7 | 36 | |
| GSE46452 | HPS1 | 3257 | 0 | 11 | 48 | |
| GSE47630 | HPS1 | 3257 | 2 | 14 | 24 | |
| GSE54993 | HPS1 | 3257 | 8 | 0 | 62 | |
| GSE54994 | HPS1 | 3257 | 2 | 11 | 40 | |
| GSE60625 | HPS1 | 3257 | 0 | 0 | 11 | |
| GSE74703 | HPS1 | 3257 | 0 | 5 | 31 | |
| GSE74704 | HPS1 | 3257 | 0 | 4 | 16 | |
| TCGA | HPS1 | 3257 | 5 | 28 | 63 |
Total number of gains: 19; Total number of losses: 95; Total Number of normals: 374.
Somatic mutations of HPS1:
Generating mutation plots.
Highly correlated genes for HPS1:
Showing top 20/294 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HPS1 | RAD51D | 0.769593 | 3 | 0 | 3 |
| HPS1 | TP53TG5 | 0.755633 | 3 | 0 | 3 |
| HPS1 | ABCA4 | 0.748738 | 3 | 0 | 3 |
| HPS1 | TRAPPC9 | 0.738186 | 5 | 0 | 5 |
| HPS1 | ATAD3C | 0.732175 | 3 | 0 | 3 |
| HPS1 | FBLN7 | 0.729051 | 3 | 0 | 3 |
| HPS1 | ZBTB45 | 0.72719 | 3 | 0 | 3 |
| HPS1 | ASMTL | 0.711591 | 3 | 0 | 3 |
| HPS1 | CACNB3 | 0.699454 | 3 | 0 | 3 |
| HPS1 | S1PR4 | 0.693318 | 4 | 0 | 3 |
| HPS1 | CRYGN | 0.691009 | 3 | 0 | 3 |
| HPS1 | VIPR2 | 0.689081 | 4 | 0 | 4 |
| HPS1 | TNN | 0.68717 | 4 | 0 | 4 |
| HPS1 | DDX49 | 0.684314 | 3 | 0 | 3 |
| HPS1 | FOXB1 | 0.679596 | 3 | 0 | 3 |
| HPS1 | ODF1 | 0.67937 | 3 | 0 | 3 |
| HPS1 | DBF4B | 0.669494 | 4 | 0 | 4 |
| HPS1 | DPM3 | 0.669467 | 4 | 0 | 3 |
| HPS1 | GFRA2 | 0.667807 | 4 | 0 | 4 |
| HPS1 | LIPE | 0.667589 | 3 | 0 | 3 |
For details and further investigation, click here
