| Full name: alkB homolog 2, alpha-ketoglutarate dependent dioxygenase | Alias Symbol: MGC90512|ABH2 | ||
| Type: protein-coding gene | Cytoband: 12q24.11 | ||
| Entrez ID: 121642 | HGNC ID: HGNC:32487 | Ensembl Gene: ENSG00000189046 | OMIM ID: 610602 |
| Drug and gene relationship at DGIdb | |||
Expression of ALKBH2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ALKBH2 | 121642 | 225625_at | 0.5587 | 0.3413 | |
| GSE26886 | ALKBH2 | 121642 | 225625_at | 0.6600 | 0.0221 | |
| GSE45670 | ALKBH2 | 121642 | 225625_at | 0.0116 | 0.9408 | |
| GSE53622 | ALKBH2 | 121642 | 92466 | 0.5121 | 0.0000 | |
| GSE53624 | ALKBH2 | 121642 | 92466 | 0.5609 | 0.0000 | |
| GSE63941 | ALKBH2 | 121642 | 225625_at | 0.9610 | 0.1018 | |
| GSE77861 | ALKBH2 | 121642 | 225625_at | 0.0415 | 0.8869 | |
| GSE97050 | ALKBH2 | 121642 | A_32_P28939 | 0.2296 | 0.3054 | |
| SRP007169 | ALKBH2 | 121642 | RNAseq | 0.0283 | 0.9624 | |
| SRP008496 | ALKBH2 | 121642 | RNAseq | -0.1528 | 0.6802 | |
| SRP064894 | ALKBH2 | 121642 | RNAseq | 0.2928 | 0.2520 | |
| SRP133303 | ALKBH2 | 121642 | RNAseq | 0.2695 | 0.3505 | |
| SRP159526 | ALKBH2 | 121642 | RNAseq | 0.6205 | 0.1027 | |
| SRP193095 | ALKBH2 | 121642 | RNAseq | 0.0525 | 0.7288 | |
| SRP219564 | ALKBH2 | 121642 | RNAseq | 0.3241 | 0.4443 | |
| TCGA | ALKBH2 | 121642 | RNAseq | 0.2711 | 0.0058 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ALKBH2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ALKBH2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ALKBH2 | 121642 | 5 | 3 | 22 | |
| GSE20123 | ALKBH2 | 121642 | 5 | 4 | 21 | |
| GSE43470 | ALKBH2 | 121642 | 2 | 1 | 40 | |
| GSE46452 | ALKBH2 | 121642 | 9 | 1 | 49 | |
| GSE47630 | ALKBH2 | 121642 | 9 | 1 | 30 | |
| GSE54993 | ALKBH2 | 121642 | 0 | 5 | 65 | |
| GSE54994 | ALKBH2 | 121642 | 3 | 3 | 47 | |
| GSE60625 | ALKBH2 | 121642 | 0 | 0 | 11 | |
| GSE74703 | ALKBH2 | 121642 | 2 | 0 | 34 | |
| GSE74704 | ALKBH2 | 121642 | 2 | 2 | 16 | |
| TCGA | ALKBH2 | 121642 | 21 | 10 | 65 |
Total number of gains: 58; Total number of losses: 30; Total Number of normals: 400.
Somatic mutations of ALKBH2:
Generating mutation plots.
Highly correlated genes for ALKBH2:
Showing top 20/189 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ALKBH2 | MIIP | 0.787611 | 3 | 0 | 3 |
| ALKBH2 | LRFN4 | 0.780745 | 3 | 0 | 3 |
| ALKBH2 | ABHD11 | 0.77051 | 3 | 0 | 3 |
| ALKBH2 | TIGD7 | 0.748256 | 3 | 0 | 3 |
| ALKBH2 | HES2 | 0.739764 | 3 | 0 | 3 |
| ALKBH2 | LRWD1 | 0.728724 | 3 | 0 | 3 |
| ALKBH2 | FBRSL1 | 0.722531 | 3 | 0 | 3 |
| ALKBH2 | KAT2A | 0.705947 | 4 | 0 | 4 |
| ALKBH2 | ETV3 | 0.69378 | 3 | 0 | 3 |
| ALKBH2 | ATAD3C | 0.689593 | 3 | 0 | 3 |
| ALKBH2 | MANEAL | 0.689159 | 3 | 0 | 3 |
| ALKBH2 | FAM189B | 0.685909 | 5 | 0 | 4 |
| ALKBH2 | LRR1 | 0.680187 | 4 | 0 | 4 |
| ALKBH2 | ZDHHC23 | 0.677858 | 5 | 0 | 5 |
| ALKBH2 | SLC27A5 | 0.676165 | 6 | 0 | 4 |
| ALKBH2 | ZNF26 | 0.673434 | 3 | 0 | 3 |
| ALKBH2 | DDX49 | 0.672834 | 4 | 0 | 3 |
| ALKBH2 | ABT1 | 0.664327 | 4 | 0 | 3 |
| ALKBH2 | WRAP73 | 0.660988 | 5 | 0 | 3 |
| ALKBH2 | PRDM13 | 0.660041 | 4 | 0 | 3 |
For details and further investigation, click here
