DENND6B

 

Full name: DENN domain containing 6B Alias Symbol: MGC33692|AFI1B
Type: protein-coding gene Cytoband: 22q13.33
Entrez ID: 414918 HGNC ID: HGNC:32690 Ensembl Gene: ENSG00000205593 OMIM ID: 

 

Expression of DENND6B:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 DENND6B 414918 228678_at 0.1071 0.6964
GSE20347 DENND6B 414918 220713_at 0.0842 0.2615
GSE23400 DENND6B 414918 220713_at -0.1060 0.0052
GSE26886 DENND6B 414918 220713_at 0.0824 0.4110
GSE29001 DENND6B 414918 220713_at -0.0229 0.8836
GSE38129 DENND6B 414918 220713_at 0.0295 0.6823
GSE45670 DENND6B 414918 220713_at 0.1921 0.0540
GSE53622 DENND6B 414918 90041 0.1717 0.0827
GSE53624 DENND6B 414918 90041 0.2497 0.0012
GSE63941 DENND6B 414918 220713_at 0.2759 0.0365
GSE77861 DENND6B 414918 228678_at -0.0425 0.8187
SRP007169 DENND6B 414918 RNAseq -0.9915 0.1732
SRP064894 DENND6B 414918 RNAseq 0.7186 0.0054
SRP133303 DENND6B 414918 RNAseq 0.1035 0.4767
SRP159526 DENND6B 414918 RNAseq 0.9010 0.0797
SRP193095 DENND6B 414918 RNAseq 0.2933 0.0424
SRP219564 DENND6B 414918 RNAseq 0.6286 0.0085

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by DENND6B expression:

 

GSE53622GSE53624

 

Note: Click image to view full size file.  

Copy number change of DENND6B:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 DENND6B 414918 3 8 19
GSE20123 DENND6B 414918 3 8 19
GSE43470 DENND6B 414918 2 8 33
GSE46452 DENND6B 414918 31 2 26
GSE47630 DENND6B 414918 9 4 27
GSE54993 DENND6B 414918 4 6 60
GSE54994 DENND6B 414918 11 8 34
GSE60625 DENND6B 414918 5 0 6
GSE74703 DENND6B 414918 2 6 28
GSE74704 DENND6B 414918 1 4 15
TCGA DENND6B 414918 26 16 54

Total number of gains: 97; Total number of losses: 70; Total Number of normals: 321.  

 

Somatic mutations of DENND6B:

 

Generating mutation plots.

 

Highly correlated genes for DENND6B:

 

Showing top 20/922 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
DENND6BDNASE2B0.721552303
DENND6BC19orf810.713497303
DENND6BUBE2D40.70961303
DENND6BCHRNA20.698314404
DENND6BCER10.693552404
DENND6BSLC10A10.693048404
DENND6BKCNF10.691627404
DENND6BPAPPA20.691251404
DENND6BCBLN10.688384303
DENND6BPCDH11X0.685853303
DENND6BPRR340.685417505
DENND6BHBQ10.685315303
DENND6BCCZ10.685235404
DENND6BLUZP40.684063404
DENND6BLRTM10.683768404
DENND6BOR11A10.683639303
DENND6BOLFM10.68358303
DENND6BMLNR0.68313303
DENND6BGPATCH40.682771404
DENND6BPEX5L0.682458404

For details and further investigation, click here