| Full name: cholinergic receptor nicotinic alpha 2 subunit | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 8p21.2 | ||
| Entrez ID: 1135 | HGNC ID: HGNC:1956 | Ensembl Gene: ENSG00000120903 | OMIM ID: 118502 |
| Drug and gene relationship at DGIdb | |||
Expression of CHRNA2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CHRNA2 | 1135 | 207868_at | -0.2066 | 0.4794 | |
| GSE20347 | CHRNA2 | 1135 | 207868_at | 0.0765 | 0.5475 | |
| GSE23400 | CHRNA2 | 1135 | 207868_at | -0.1875 | 0.0000 | |
| GSE26886 | CHRNA2 | 1135 | 207868_at | -0.2289 | 0.0348 | |
| GSE29001 | CHRNA2 | 1135 | 207868_at | -0.1692 | 0.3037 | |
| GSE38129 | CHRNA2 | 1135 | 207868_at | -0.0544 | 0.5879 | |
| GSE45670 | CHRNA2 | 1135 | 207868_at | 0.0853 | 0.3782 | |
| GSE53622 | CHRNA2 | 1135 | 17231 | 0.1555 | 0.1723 | |
| GSE53624 | CHRNA2 | 1135 | 17231 | -0.5201 | 0.0000 | |
| GSE63941 | CHRNA2 | 1135 | 207868_at | 0.0028 | 0.9859 | |
| GSE77861 | CHRNA2 | 1135 | 207868_at | -0.2226 | 0.0269 | |
| GSE97050 | CHRNA2 | 1135 | A_23_P251443 | -0.0491 | 0.9022 | |
| TCGA | CHRNA2 | 1135 | RNAseq | -0.2210 | 0.8429 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CHRNA2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CHRNA2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CHRNA2 | 1135 | 4 | 11 | 15 | |
| GSE20123 | CHRNA2 | 1135 | 4 | 11 | 15 | |
| GSE43470 | CHRNA2 | 1135 | 4 | 7 | 32 | |
| GSE46452 | CHRNA2 | 1135 | 13 | 13 | 33 | |
| GSE47630 | CHRNA2 | 1135 | 10 | 8 | 22 | |
| GSE54993 | CHRNA2 | 1135 | 2 | 15 | 53 | |
| GSE54994 | CHRNA2 | 1135 | 10 | 15 | 28 | |
| GSE60625 | CHRNA2 | 1135 | 3 | 0 | 8 | |
| GSE74703 | CHRNA2 | 1135 | 4 | 6 | 26 | |
| GSE74704 | CHRNA2 | 1135 | 3 | 8 | 9 | |
| TCGA | CHRNA2 | 1135 | 16 | 43 | 37 |
Total number of gains: 73; Total number of losses: 137; Total Number of normals: 278.
Somatic mutations of CHRNA2:
Generating mutation plots.
Highly correlated genes for CHRNA2:
Showing top 20/1350 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CHRNA2 | SPEF2 | 0.764831 | 3 | 0 | 3 |
| CHRNA2 | STRC | 0.759961 | 3 | 0 | 3 |
| CHRNA2 | FAM171A2 | 0.753912 | 4 | 0 | 4 |
| CHRNA2 | MAGEA8 | 0.749596 | 3 | 0 | 3 |
| CHRNA2 | FOXA3 | 0.742863 | 3 | 0 | 3 |
| CHRNA2 | OR4D6 | 0.730171 | 3 | 0 | 3 |
| CHRNA2 | SPACA3 | 0.722793 | 3 | 0 | 3 |
| CHRNA2 | SLC6A19 | 0.72206 | 3 | 0 | 3 |
| CHRNA2 | SLC5A4 | 0.718636 | 6 | 0 | 6 |
| CHRNA2 | RBAKDN | 0.717275 | 3 | 0 | 3 |
| CHRNA2 | KRTAP10-12 | 0.715255 | 3 | 0 | 3 |
| CHRNA2 | CLHC1 | 0.713494 | 3 | 0 | 3 |
| CHRNA2 | SLC39A5 | 0.713417 | 3 | 0 | 3 |
| CHRNA2 | CHRM2 | 0.711866 | 5 | 0 | 5 |
| CHRNA2 | ZNF835 | 0.711196 | 5 | 0 | 4 |
| CHRNA2 | PLA2G2C | 0.709162 | 3 | 0 | 3 |
| CHRNA2 | SYPL2 | 0.706578 | 3 | 0 | 3 |
| CHRNA2 | C20orf173 | 0.704284 | 4 | 0 | 4 |
| CHRNA2 | SPINT3 | 0.700212 | 9 | 0 | 9 |
| CHRNA2 | ART1 | 0.699965 | 7 | 0 | 6 |
For details and further investigation, click here
